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Publication in Nature Communications: A fly model for ageing research
The story of Ana Bratic and Timo Kauppila from the Max Planck Institute for Biology of Ageing shows how science many times works. At the beginning of a project you have an hypothesis, you test it, get a completely unexpected result and gain new, exciting insights. Ana and Timo developed a model which can be used to study how the decrease or increase in the accuracy of polymerase gamma affects the ageing process of fruit flies.[more]
Publication in Nature Communications: How does the skin regulate its stem cells?
Our skin protects us from external insults such as pathogens and toxic substances and our body from dehydration. In order to fulfill these essential functions, the skin must be constantly renewed. When we grow old, the regenerative potential of the skin deteriorates. The necessary supply of new skin cells is provided by its stem cells. Researchers at the Max Planck Institute for Biology of Ageing in Cologne have now found that integrin-linked kinase, a molecule that has been known to regulate attachment of cells to their environment, also regulates the activity of hair follicle stem cells in the skin and thereby maintains the natural balance of the skin. Impaired function of this pseudokinase leads to enhanced activation of the hair follicle stem cells, which then predisposes the skin to the development of skin tumors.[more]
AXA Research Fund junior fellowship awarded to Dr. Francesca Baggio
The AXA Research Fund has the mission to fund basic research dedicated to a better understanding of current global societal challenges. Age-associated pathologies, such as Alzheimer's and Parkinson's disease, are an ever-increasing burden for our society. To identify novel mitochondrial proteins modulating these age-related diseases is the goal of Dr. Francesca Baggio's new project at the Max Planck Institute for Biology of Ageing.[more]