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September 01st, 2014

New Research Group "Metabolic and Genetic Regulation of Ageing" at the MPI for Biology of Ageing


On September 1st Dr. Martin Denzel starts his lab at the MPI for Biology of Ageing as a Research Group Leader in "Metabolic and Genetic Regulation of Ageing". Previously, he carried out his research in the Department "Molecular Genetics of Ageing", headed by MPI Director Adam Antebi. Here, Denzel and colleagues have found that a naturally occurring molecule has the ability to enhance defence mechanisms against neurodegenerative diseases. Feeding this particular metabolite to the small round worm C. elegans can help clear toxic protein aggregates in the body and extend life span. Aggregated proteins are the hallmark of neurodegenerative diseases such as Alzheimer's and Huntington's disease.

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August 14th, 2014

New Research Group "Epigenetic Regulation of Mammalian Ageing" at the MPI for Biology of Ageing


On August 1st Dr. Xiangru Xu officially started his lab at the Max Planck Institute for Biology of Ageing as a Research Group Leader in "Epigenetic Regulation of Mammalian Ageing". Recent studies indicate that epigenetics play a fundamental role both in the normal ageing process and in the pathogenesis of a number of age-related disorders. In epigenetics, scientists study heritable changes in the chromosomes that are not caused by changes in the DNA sequence: changes that occur in an individual's life time, caused by environmental factors.

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August 07th, 2014

Publication in Science: toxic proteins cause neurodegeneration in motor neuron disease and dementia


Recent findings in basic biomedical research might pave the way towards novel therapies: Scientists at the Max Planck Institute for Biology of Ageing in Cologne and University College London have now unearthed the way in which a specific genetic mutation leads to neuronal damage in two serious afflictions, that might even occur at once in a single person: Hitherto, it has been unknown what causes amyotrophic lateral sclerosis and frontotemporal dementia. Now, the scientists have uncovered that a specific genetic mutation entails the production of arginine-containing proteins that are highly neuro toxic.

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