Core Facilities

Bio-MS

We provide a mass spectrometry infrastructure for the identification, characterization, and absolute label free quantification of proteins and the targeted absolute quantification of small molecules in complex biological matrices. The core is a state-of-the-art mass spectrometry lab equipped with UPLC and 2D-nano-UPLC for LC-MS/MS and LC-MRM experiments. For protein and peptide separation and pre-fractionation we offer. [more...]

Selected publications

Cámara, Y., Asin-Cayuela, J., Park, C.B., Metodiev, M.D., Shi, Y., Ruzzenente, B., Kukat, C., Habermann, B., Wibom, R., Hultenby, K., Franz, T., Erdjument-Bromage, H., Tempst, P., Hallberg, B.M., Gustafsson, C.M., Larsson, N.-G. (2011). MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome. Cell Metabolism 13, 527-539.

Reuter, M., Chuma, S., Tanaka, T., Franz, T., Stark, A., Pillai, R.S. (2009). Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol. 16, 639-646.

Li, X., Wilm, M., Franz, T.  (2005). Silicone/Graphite coating for on-target desalting and improved peptide mapping performance of matrix-assisted laser desorption/ionization-mass spectrometry targets in proteomic experiments. Proteomics  5, 1460-1471.

Sola, M., Bavro, V.N., Timmins, J., Franz, T., Ricard-Blum, S., Schoehn, G., Ruigrok, R.W.H., Paarmann, I., Saiyed, T., O'Sullivan, G.A., Schmitt, B., Betz, H., Weissenhorn, W. (2004). Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO Journal 23, 2510-2519.

Franz, T., Hein, M., Veith, U., Jäger, V., Peters, E.-M., Peters, K., Schnering, H.G. (1994). Simple and Versatile Synthesis of Optically Active 1,2-Amino Alcohols by Grignard Addition to N,O-Dibenzylglyceraldimin and Lactaldimin. Angew. Chem. Int. Ed. Engl. 33, 1298-1301.