Core Facilities: Transgenesis

Assessment of mouse embryos

Transgenic Service

Genetically modified models represent one of the most powerful methods of functional gene analysis in vivo. Important is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely [ more... ]

Selected publications

Dobbernack G., Meinl W., Schade N., Florian S., Wend K., Voigt I., Himmelbauer H, Gross M., Liehr T., Glatt H. (2011). Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2. Carcinogenesis 32,1734-40.

Deng D.R., Djalali S., Höltje M., Grosse G., Stroh T., Voigt I., Kusserow H., Theuring F., Ahnert-Hilger G., Hörtnagl H. (2007). Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants.
Neuroscience 147, 388-402.

Kusserow H., Davies B., Hörtnagel H., Voigt I., Stroh T., Bert B., Deng D.R., Fink H, Veh R.W. Theuring F. (2004). Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors. BrainRes Mol Brain Res.129, 104-16.

Strauch E., Voigt I., Broll H, Appel B. (2000). Use of a plasmid of a yersinia enterocolitica biogroup 1A strain for the construction of cloning vectors. J Biotechnol. 79, 63-72.