Skin Homeostasis and Ageing
The physiological process that maintains a constant number of cells in a renewing organ is called tissue homeostasis. The mammalian skin is ideal for investigating the mechanisms of this process, as it undergoes self-renewal throughout the lifetime of the organism. Our research addresses two fundamental questions: What are the basic principles that govern the balance of proliferation and differentiation enable the maintenance of the skin as a robust but continuously self-renewing organ? How do the dynamics of this balance change upon ageing resulting in tissue dysfunction and disease? [more...]
Radovanac, K.*, Morgner, J.*, Schultz, J.N., Blumbach, K., Patterson, C., Geiger, T., Mann, M., Krieg, T., Eckes, B., Fässler, R., Wickström, S.A. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBOJ. doi:10.1038/emboj.2013.90 *Equal contribution
Wickström, S.A.*, Radovanac, K., and Fässler, R. (2011). Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol 3, a005116.
* Corresponding author
Wickström, S.A.*, Lange, A., Hess, M.W., Polleux, J., Spatz, J.P., Kruger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., et al. (2010). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell 19, 574-588.
* Corresponding author
Wickström, S.A., Masoumi, K.C., Khochbin, S., Fässler, R., and Massoumi, R. (2010). CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. Embo J 29, 131-144.
Lange, A., Wickström, S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461, 1002-1006.
- 2013-2016 | DFG
SFB 829: Molecular mechanisms regulating skin homeostasis - Subproject A11: Regulation of epidermal stratification and homeostasis through contractility and density sensing
- 2013-2015 | Behrens-Weise Foundation
Role of rigidity sensing in skin homeostasis and aging
- 2012-2015 | NRW Academy of Arts and Sciences/ Stiftung Mercator
Skin homeostasis and ageing