Molecular Genetics of Ageing
Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. Yet work from model genetic organisms reveals that animals possess natural defense mechanisms that help stave off ageing, increase organismal homeostasis and stimulate longevity. [more...]
Shen, Y., Wollam, J., Magner, D., Karalay, O., and Antebi, A. (2012) A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science 338(6113):1472-6.
Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., Antebi, A. (2011) The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell. 2011, 10, 879-884.
(featured in Science Signaling, editors choice 2, ec 120).
Bethke, A., Fielenbach, N., Wang, Z., Mangelsdorf, D.J., Antebi, A. (2009) Nuclear Hormone Receptor Regulation of microRNAs Controls Developmental Progression, Science 324, 95-98.
Fielenbach, N., Guardavaccaro, D., Neubert, K., Chan, T., Li, D., Feng, Q., Hutter, H., Pagano, M., Antebi, A. (2007) DRE-1, an evolutionarily conserved F-box protein that regulates C. elegans developmental age, Developmental Cell 12, 443-455.
Gerisch,B., Rottiers, V., Li, D., Motola, D., Cummins. C.L, Lehrach, H., Mangelsdorf, D. J. and Antebi, A. (2007) A bile acid-like steroid modulates C. elegans life span through nuclear receptor signaling, PNAS 104, 5014-5019.
Motola, D. Cummins,C.L., Rottiers, V., Sharma, K., Sunino, K. ,Xu, E., Auchus, R., Antebi, A. and D. Mangelsdorf (2006) Identification of hormonal ligands for DAF-12 that govern dauer formation and reproduction in C. elegans Cell, 124, 1209-23 (featured in Cell Minireview 124, 1137-40).
- 2013 | DFG
CECAD: EXC 229 - to support collaborative research
- 2011-2015 | BMBF
GERONTOSYS - Forschungskern: SyBACol (Systems Biology of Ageing Cologne); Project Area A: Systems Biology of Longevity Pathways; Subproject B
- 2011-2015 | DFG
SFB 635: Posttranslational control of protein function, Project C9: Regulation of C. elegans Developmental Timing by the F-box Protein DRE-1/FBXO11
- 2011-2012 | DFG
CECAD Project: Metabolomic Profiling of C. elegans Longevity