Department Partridge

Biological Mechanisms of Ageing

Human life expectancy has been increasing steadily since the middle of the nineteenth century. Improvements in lifestyle and health care have kept people healthier as they age, and so they are living longer. However, the downside is that age is the major risk factor for the predominant chronic and killer conditions: cancer, cardiovascular and neurodegenerative disease. The major burden of ill health is hence falling on the older section of the population. The aim of our research is to discover ways of keeping people healthy for longer as they age. [more...]

Selected publications

Mizielinska, S., Gronke, S., Niccoli, T., Ridler, C.E., Clayton, E.L., Devoy, A., Moens, T., Norona, F.E., Woollacott, I.O., Pietrzyk, J., Cleverley, K., Nicoll, A. J., Pickering-Brown, S., Dols, J., Cabecinha, M., Hendrich, O., Fratta, P., Fisher, E. M., Partridge, L., and Isaacs, A. M. (2014). C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science 345, 1192-1194.

Metaxakis, A., Tain, L.S., Grönke, S., Hendrich, O., Hinze, Y., Birras, U., and Partridge, L. (2014). Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. PLoS Biol 12, e1001824.

Alic, N., Tullet, J.M., Niccoli, T., Broughton, S., Hoddinott, M.P., Slack, C., Gems, D., and Partridge, L. (2014). Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging. Cell reports 6, 608-616.

Piper, M.D., Blanc, E., Leitao-Goncalves, R., Yang, M., He, X., Linford, N.J., Hoddinott, M.P., Hopfen, C., Soultoukis, G.A., Niemeyer, C., Kerr, F., Pletcher, S. D., Ribeiro, C., and Partridge, L. (2014). A holidic medium for Drosophila melanogaster. Nat Methods 11, 100-105.

Alic, N., Andrews, T.D., Giannakou, M.E., Papatheodorou, I., Slack, C., Hoddinott, M.P., Cocheme, H.M., Schuster, E.F., Thornton, J.M., and Partridge, L. (2011). Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol 7, 502.



Third-party funding

  • 2013 - 2017 | DFG
    CECAD: EXC 229 - to support collaborative research

  • 2011-2016 | European Research Council (ERC) FP7, Advanced Grant
    Experimental Research on Ageing

  • 2011-2015 | BMBF
    GERONTOSYS - Forschungskern: SyBACol - Kölner Verbund für Systembiologie des Alterns - Teilprojekt B (joint with Adam Antebi and Bianca Habermann)

  • 2011-2014 | Max Planck Society
    Toxic Protein Conformation: Ageing as a Risk Factor for Protein Toxicity in the Fruit Fly Drosophila

  • 2011-2013 | EU & MIWF NRW im Rahmen des aus dem EFRE ko-finanzierten Operationellen Programms für NRW im Ziel 2 "Regionale Wettbewerbsfähigkeit und Beschäftigung" 2007-2013
    Geweberegeneration: Vom Modellorganismus zur Therapie (joint with Sabine Eming, TaconicArtemis Pharmaceuticals GmbH)

  • 2011-2012 | DFG
    CECAD: Ageing in Drosophila

  • 2009-2012 | DFG
    SFB 829: Molecular mechanisms regulating skin homeostasis - Pathophysiology of skin ageing and ageing-associated ulcerative dermatitis in mice

Scientific & Personal Assistance

Dr. Christine Lesch

Tel.: +49 (0)221 37970-602
Fax: +49 (0)221 37970-

E-mail: Lesch[at]

Sackler Lecture 2012

Academy of Medical Sciences 2012 Sackler Lecture given by Linda Partridge on the science of ageing at the University of Cambridge.

Introduction video (3:35)
Lecture full length (48:00)

Video interview

"Recent discoveries
in ageing research":

Watch the video interview with Linda Partridge on the margins of the 4th EMBO Meeting in Nice, September 2012:

Interview part I
Interview part II

Also see: news

Tagging proteins with GFP

GFP is a "green-fluorescent protein" that is often used in cellular and molecular biology to tag proteins. For instance, we make use of it in order to track the Tau protein in vivo in transgenic Drosophila. Tau is known to be important in Alzheimer´s disease.
Watch the movie!