Biological Mechanisms of Ageing
Human life expectancy has been increasing steadily since the middle of the nineteenth century. Improvements in lifestyle and health care have kept people healthier as they age, and so they are living longer. However, the downside is that age is the major risk factor for the predominant chronic and killer conditions: cancer, cardiovascular and neurodegenerative disease. The major burden of ill health is hence falling on the older section of the population. The aim of our research is to discover ways of keeping people healthy for longer as they age. [more...]
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., and Partridge, L. (2012). Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLoS ONE 7, e40569.
Slack, C., Giannakou, M.E., Foley, A., Goss, M., and Partridge, L. (2011). dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell 10, 735-748.
Alic, N., Andrews, T.D., Giannakou, M.E., Papatheodorou, I., Slack, C., Hoddinott, M.P., Cocheme, H.M., Schuster, E.F., Thornton, J.M., and Partridge, L. (2011). Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol 7, 502.
Bjedov, I., Toivonen, J.M., Kerr, F., Slack, C., Jacobson, J., Foley, A., and Partridge, L. (2010). Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 11, 35-46.
Grandison, R.C., Piper, M.D., and Partridge, L. (2009). Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462, 1061-1064.
- 2013 | DFG
CECAD: EXC 229 - to support collaborative research
- 2011-2016 | European Research Council (ERC) FP7, Advanced Grant
Experimental Research on Ageing
- 2011-2015 | BMBF
GERONTOSYS - Forschungskern: SyBACol - Kölner Verbund für Systembiologie des Alterns - Teilprojekt B (joint with Adam Antebi and Bianca Habermann)
- 2011-2014 | Max Planck Society
Toxic Protein Conformation: Ageing as a Risk Factor for Protein Toxicity in the Fruit Fly Drosophila
- 2011-2013 | MIWF NRW
Bio.NRW: Geweberegeneration: Vom Modellorganismus zur Therapie (joint with Sabine Eming, Bayer Innovation GmbH and TaconicArtemis Pharmaceuticals GmbH)
- 2011-2012 | DFG
CECAD: Ageing in Drosophila
- 2009-2012 | DFG
SFB 829: Molecular mechanisms regulating skin homeostasis - Pathophysiology of skin ageing and ageing-associated ulcerative dermatitis in mice
Scientific & Personal Assistance
Dr. Christine Lesch
Tel.: +49 (0)221 37970-602
Fax: +49 (0)221 37970-906
Tagging proteins with GFP
GFP is a "green-fluorescent protein" that is often used in cellular and molecular biology to tag proteins. For instance, we make use of it in order to track the Tau protein in vivo in transgenic Drosophila. Tau is known to be important in Alzheimer´s disease.
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