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September 2019

Datum Veranstaltung Ort
16. September 2019
Monday,
16:0017:00 Uhr
CSA

Title to be announced

Redner: Claudia Cavadas (PRT)
Veranstalter: Björn Schumacher

There will be wine and cheese and the possibility for further discussion after the talk.

lecture hall, ground floor
CECAD Research Center
Joseph-Stelzmann-Str. 26
Cologne
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26. September 2019
Thursday,
16:0017:00 Uhr
CSA

Targeting the Cell’s Stress Pathways for Therapeutic Benefit

Redner: Peter Walter (USA)
Veranstalter: Dusanka Milenkovic

There will be wine and cheese and the possibility for further discussion after the talk.

About the talk:

From leaving their ribosome cradles to their demise in the fangs of proteolytic enzymes, proteins continuously explore different folding states. In most cell compartments, molecular sensors carefully monitor protein folding and instruct downstream effectors to take corrective actions as needed. In response, cells can make adjustments to their protein folding and degradation machineries to stay in a healthy state of homeostasis. If protein folding defects occur and cannot be corrected sufficiently and timely, cells induce suicide programs. Programmed cell death is thought to protect an organism from malfunctioning, rogue cells that result from an accumulation of defective protein. In various pathologies, the life/death balance can inappropriately err on either side: killing cells that would be beneficial if kept alive, or alternatively inappropriately protecting dangerous, disease propagating cells. Studies of the regulation of proteostasis now emerge as focal points of foundational basic research that powerfully connects to a wide spectrum of unmet clinical needs.
We will discuss advances in our lab’s efforts to understand the molecular details of the unfolded protein response (UPR), a conserved signaling network that surveys the protein folding status in the endoplasmic reticulum. The UPR signals through three molecularly distinct branches. The development of small, drug-like molecules that selectively target each of the UPR’s signaling branches has opened promising new therapeutic opportunities in areas as divergent as cancer, neurodegeneration, diabetes, inflammation, aging, and cognition. As such, the UPR emerges as a prime example of the power of fundamental cell biological discoveries to address problems of immense societal impact.

Auditorium, ground floor
Max Planck Institute for Biology of Ageing
Joseph-Stelzmann-Str. 9b
Cologne
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27. September 2019
Friday,
19:0021:00 Uhr
MPI

AGE ART - Science meets Music

Redner: Dr. Peter Walter (UCSF)
Veranstalter: Helen Antebi (MPI for Biology of Ageing)

Dr. Peter Walter from the University of California, San Francisco has won numerous awards and recognition in the field of biochemistry and molecular biology, including the Lasker Award, the Shaw Prize and Breakthrough Prize in Life Sciences. In his talk "The Art of Protein Origami" he will focus on proteins, how cells fold them properly and why mistakes in protein folding lead to ageing and ageing related diseases such as cancer, alzheimer or diabetes.

The SIGNUM Saxophone Quartet is a star in its own right. They are one of the most sought after young musicians in the concert circuit today. The four musicians Blaž Kemperle, Hayrapet Arakelyan, Alan Lužar and Guerino Bellarosa will play selected pieces by Johann Sebastian Bach, Alberto Ginastera, Leonard Bernstein and "Chick" Corea.

The event will be held in English. Entrance is free. As space is limited please register via our online registration form.

Auditorium
Max-Planck-Institut für Biologie des Alterns
Joseph-Stelzmann-Str. 9b
50931 Köln
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