Associated Research Group Rorbach

Mitochondrial gene expression

Mitochondria house their own genetic system for the expression of thirteen oxidative phosphorylation (OxPhos) subunits encoded by the mitochondrial DNA. Dysfunction of mitochondrial gene expression can lead to human pathologies, and yet our understanding of the basic aspects of mitochondrial genetics remains limited.
Our group employs genetic, proteomic and cryo-EM methods to reveal mechanisms and to identify novel factors involved in mitochondrial gene expression.
This interdisciplinary approach helps us to explore a poorly-understood area of mitochondrial biology with direct relevance to human health.

The specific objectives of our research are:

  1. To characterise, both structurally and biochemically, the mechanisms of mitochondrial protein synthesis.
  2. To investigate mitoribosome biogenesis, including determining the composition and structure of assembly intermediates at different biogenesis stages and identifying novel assembly factors.
  3. To identify and characterise novel factors involved in the regulation of mitochondrial RNA metabolism and translation.
  4. To investigate how defects in mitochondrial gene expression influence human health.

[ more about our research ]

*equal contribution; **corresponding author

Third-party funding

  • 2020-2025 | Wallenberg Research Grant ‘Mitochondrial Methyltransferases - From discovery to disease’
  • 2019-2024 | Wallenberg Research Grant ‘Birth of mitochondrial ribosome’
  • 2019-2020 | Wenner Gren Fellowship
  • 2018-2023 | Wallenberg Academy Fellowship
  • 2018-2020 | Ake Wibergs Fellowship
  • 2018-2020 | Blanceflor Foundation Scholarship
  • 2018-2022 | CSC-KI graduate fellowship
  • 2016-2019 | Marie Curie International Grant