Department Schaefer

Neurobiology of Ageing

One of the most fascinating problems of human biology is the bi-directionality of changes that happen during brain ageing. As we age, we gain knowledge and experience, develop skills, and store memories that define our personality and behaviour. At the same time, the  age-associated cognitive advances are marred by decline in neuronal function that may take a particularly dramatic turn in the late stages of human life. How can the wisdom and peril of ageing co-exist and what are the mechanism of these intertwined processes remains largely unknown.

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Corinna Schwierzy-Krämer

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Selected publications

Negative feedback control of neuronal activity by microglia

  • Badimon, A.
  • Strasburger, H. J.
  • Ayata, P.
  • Chen, X.
  • Nair, A.
  • Ikegami, A.
  • Hwang, P.
  • Chan, A. T.
  • Graves, S. M.
  • Uweru, J. O.
  • Ledderose, C.
  • Kutlu, M. G.
  • Wheeler, M. A.
  • Kahan, A.
  • Ishikawa, M.
  • Wang, Y. C.
  • Loh, Y. E.
  • Jiang, J. X.
  • Surmeier, D. J.
  • Robson, S. C.
  • Junger, W. G.
  • Sebra, R.
  • Calipari, E. S.
  • Kenny, P. J.
  • Eyo, U. B.
  • Colonna, M.
  • Quintana, F. J.
  • Wake, H.
  • Gradinaru, V.
  • Schaefer, A.
(2020) Nature, 586, 7829, 417-423

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

  • Gunner, G.
  • Cheadle, L.
  • Johnson, K. M.
  • Ayata, P.
  • Badimon, A.
  • Mondo, E.
  • Nagy, M. A.
  • Liu, L.
  • Bemiller, S. M.
  • Kim, K. W.
  • Lira, S. A.
  • Lamb, B. T.
  • Tapper, A. R.
  • Ransohoff, R. M.
  • Greenberg, M. E.
  • Schaefer, A.
  • Schafer, D. P.
(2019) Nat Neurosci, 22, 7, 1075-1088

Epigenetic regulation of brain region-specific microglia clearance activity

  • Ayata, P.
  • Badimon, A.
  • Strasburger, H. J.
  • Duff, M. K.
  • Montgomery, S. E.
  • Loh, Y. E.
  • Ebert, A.
  • Pimenova, A. A.
  • Ramirez, B. R.
  • Chan, A. T.
  • Sullivan, J. M.
  • Purushothaman, I.
  • Scarpa, J. R.
  • Goate, A. M.
  • Busslinger, M.
  • Shen, L.
  • Losic, B.
  • Schaefer, A.
(2018) Nat Neurosci, 21, 8, 1049-1060

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

  • von Schimmelmann, M.
  • Feinberg, P. A.
  • Sullivan, J. M.
  • Ku, S. M.
  • Badimon, A.
  • Duff, M. K.
  • Wang, Z.
  • Lachmann, A.
  • Dewell, S.
  • Ma'ayan, A.
  • Han, M. H.
  • Tarakhovsky, A.
  • Schaefer, A.
(2016) Nat Neurosci, 19, 10, 1321-30

MicroRNA-128 governs neuronal excitability and motor behavior in mice

  • Tan, C. L.
  • Plotkin, J. L.
  • Veno, M. T.
  • von Schimmelmann, M.
  • Feinberg, P.
  • Mann, S.
  • Handler, A.
  • Kjems, J.
  • Surmeier, D. J.
  • O'Carroll, D.
  • Greengard, P.
  • Schaefer, A.
(2013) Science, 342, 6163, 1254-8

Third-party funding

06/2021 - 05/2027 |  European Research Council (Schaefer, Brose, Triller, Oertner MPI), ERC Synergy Grant, Micro-'COPS' - Microglia-control of physiological brain states