FOR5762 Seminar: Integrating Mitochondrial Resilience: From Subcellular Stress Signaling to Systemic Aging

Dr. Ye Tian earned her B.S. degree in Biotechnology from Beijing Normal University in 2005, followed by a Ph.D. degree in Biochemistry and Molecular Biology from a joint program of Beijing Normal University and the National Institute of Biological Sciences, Beijing in 2010. Her academic journey continued with postdoctoral training at the Salk Institute and the University of California, Berkeley from 2010 to 2016. In 2016, she assumed the role of Principal Investigator at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing. Her research focuses on the regulatory mechanisms of mitochondrial stress and aging, resulting in several achievements. These include the discovery that neuronal mitochondria can transmit "stress memory" across generations by increasing mitochondrial DNA copy numbers in germ cells, enhancing offspring stress resistance and lifespan. Additionally, her work identified various cross-tissue mitochondrial signal exchanges influencing overall metabolism and aging. Furthermore, she uncovered the role of mitochondrial metabolites in regulating aging through epigenetic factors, providing a theoretical foundation for targeting metabolites to mitigate aging.