Publications

Calabrese, C.; Nolte, H.; Pitman, M. R.; Ganesan, R.; Lampe, P.; Laboy, R.; Ripa, R.; Fischer, J.; Polara, R.; Panda, S. K. et al.; Chipurupalli, S.; Gutierrez, S.; Thomas, D.; Pitson, S. M.; Antebi, A.; Robinson, N.: Mitochondrial translocation of TFEB regulates complex I and inflammation. EMBO Reports (2024)

Ahola, S.; Langer, T.: Ferroptosis in mitochondrial cardiomyopathy. Trends in Cell Biology 34, pp. 150 - 160 (2024)

Baker, M. J.; Blau, K. U.; Anderson, A. J.; Palmer, C. S.; Fielden, L. F.; Crameri, J. J.; Milenkovic, D.; Thorburn, D. R.; Frazier, A. E.; Langer, T. et al.; Stojanovski, D.: CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex. Journal of Cell Biology 223 (2024)

Khetarpal, S. A.; Li, H.; Vitale, T.; Rhee, J.; Grauvogel, L.; Castro, C.; Mittenbühler, M. J.; Houstis, N. E.; Vargas-Castillo, A.; Smythers, A. L. et al.; Liu, J.; Curtin, C.; Sprenger, H.-G.; Blackmore, K. A.; Kuznetsov, A.; Freeman, R.; Bogoslavski, D.; Ellinor, P. T.; Asnani, A.; Dumesic, P. A.; Puigserver, P.; Roh, J. D.; Spiegelman, B. M.; Rosenzweig, A.: Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy. bioRxiv, p. 2024.01.30.578093 (2024)

Sprenger, H.-G.; Mittenbühler, M. J.; Sun, Y.; Vranken, J. G. V.; Schindler, S.; Jayaraj, A.; Khetarpal, S. A.; Vargas-Castillo, A.; Puszynska, A. M.; Spinelli, J. B. et al.; Armani, A.; Kunchok, T.; Ryback, B.; Seo, H.-S.; Song, K.; Sebastian, L.; O’Young, C.; Braithwaite, C.; Dhe-Paganon, S.; Burger, N.; Mills, E. L.; Gygi, S. P.; Arthanari, H.; Chouchani, E. T.; Sabatini, D. M.; Spiegelman, B. M.: Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST. bioRxiv, p. 2024.04.10.588849 (2024)

Grotehans, N.; McGarry, L.; Nolte, H.; Xavier, V.; Kroker, M.; Narbona-Pérez, Á. J.; Deshwal, S.; Giavalisco, P.; Langer, T.; MacVicar, T.: Ribonucleotide synthesis byNME6fuels mitochondrial gene expression. The EMBO Journal (2023)

Kim, J. Y.; Atanassov, I.; Dethloff, F.; Kroczek, L.; Langer, T.: Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria. Life science alliance 6 (9), e202302127 (2023)

Montoro-Gámez, C.; Nolte, H.; Molinié, T.; Evangelista, G.; Tröder, S.; Barth, E.; Popovic, M.; Trifunovic, A.; Zevnik, B.; Langer, T. et al.; Rugarli, E. I.: SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model ofSPG7deficiency. Brain (2023)

Adriaenssens, E.; Asselbergh, B.; Rivera-Mejías, P.; Bervoets, S.; Vendredy, L.; De Winter, V.; Spaas, K.; de Rycke, R.; van Isterdael, G.; Impens, F. et al.; Langer, T.; Timmerman, V.: Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space. Nature Cell Biology (2023)

Di Sante, M.; Antonucci, S.; Pontarollo, L.; Cappellaro, I.; Segat, F.; Deshwal, S.; Greotti, E.; Grilo, L. F.; Menabò, R.; Di Lisa, F. et al.; Kaludercic, N.: Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation. Basic Research in Cardiology 118, 4 (2023)

Deshwal, S.; Onishi, M.; Tatsuta, T.; Bartsch, T.; Cors, E.; Ried, K.; Lemke, K.; Nolte, H.; Giavalisco, P.; Langer, T.: Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nature Cell Biology (2023)

Ahola, S.; Langer, T.: Ferroptosis in mitochondrial cardiomyopathy. Trends in Cell Biology (2023)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35, pp. 786 - 806.e13 (2023)

Kohler, A.; Carlström, A.; Nolte, H.; Kohler, V.; Jung, S.-j.; Sridhara, S.; Tatsuta, T.; Berndtsson, J.; Langer, T.; Ott, M.: Early fate decision for mitochondrially encoded proteins by a molecular triage. Molecular Cell (2023)

Peker, E.; Weiss, K.; Song, J.; Zarges, C.; Gerlich, S.; Boehm, V.; Trifunovic, A.; Langer, T.; Gehring, N. H.; Becker, T. et al.; Riemer, J.: A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. Journal of Cell Biology 222 (2023)

Rivera Mejias, P.; Narbona-Pérez, Á. J.; Hasberg, L.; Kroczek, L.; Bahat, A.; Lawo, S.; Folz-Donahue, K.; Schumacher, A. L.; Ahola, S.; Mayer, F. C. et al.; Giavalisco, P.; Nolte, H.; Lavandero, S.; Langer, T.: The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. Cell Reports 42, 112332, p. 112332 (2023)

Poláchová, E.; Bach, K.; Heuten, E.; Stanchev, S.; Tichá, A.; Lampe, P.; Majer, P.; Langer, T.; Lemberg, M. K.; Stříšovský, K.: Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. Journal of Medicinal Chemistry (2022)

Jauch, A. S.; Wohlfeil, S. A.; Weller, C.; Dietsch, B.; Häfele, V.; Stojanovic, A.; Kittel, M.; Nolte, H.; Cerwenka, A.; Neumaier, M. et al.; Schledzewski, K.; Sticht, C.; Reiners-Koch, P.-S.; Goerdt, S.; Géraud, C.: Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis. Cancer Cell International 22, 398 (2022)

Miliara, X.; Tatsuta, T.; Eiyama, A.; Langer, T.; Rouse, S. L.; Matthews, S.: An intermolecular hydrogen bonded network in the PRELID-TRIAP protein family plays a role in lipid sensing. Biochim Biophys Acta Proteins Proteom 1871 (1), p. 140867 (2022)

Ahola, S.; Rivera Mejias, P.; Hermans, S.; Chandragiri, S.; Giavalisco, P.; Nolte, H.; Langer, T.: OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metab 34 (11), pp. 1875 - 1891 e7 (2022)