Department Partridge (in dismantling)

Biological Mechanisms of Ageing

The aim of the department of Biological Mechanisms of Ageing is to discover evolutionarily conserved dietary, genetic and pharmacological interventions that can improve health and function during ageing. We investigate the mechanisms at work using an experimental approach that takes advantage of an interplay between the fruit fly Drosophila and the mouse and that paves the way for development of a broad spectrum, preventative medicine for diseases associated with human ageing.  

Selected publications

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
Juricic, P., Lu, Y.-X., Leech, T., Lisa, F., Paulitz, J., Lu, J., Nespital, T., Azami, S., Regan, J. C., Funk, E. et al.
Nature aging (2), pp. 824 - 836 (2022)

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
Lu, Y.-X., Regan, J. C., Esser, J., Drews, L. F., Weinseis, T., Stinn, J., Hahn, O., Miller, R. A., Grönke, S.; Partridge, L. 
Elife 10 (2021)

Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids 
Lu, J., Temp, U., Müller-Hartmann, A., Esser, J., Grönke, S., Partridge, L.
Nature Aging 1 (1), pp. 60 - 72 (2021)

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
Weigelt, C. M., Sehgal, R., Tain, L., Cheng, J., Esser, J., Pahl, A., Dieterich, C., Grönke, S., Partridge, L.
Mol Cell 79 (2), pp. 268 - 279 e5 (2020)

A nutritional memory effect counteracts benefits of dietary restriction in old mice
Hahn, O., Drews, L. F., Nguyen, A., Tatsuta, T., Gkioni, L., Hendrich, O., Zhang, Q., Langer, T., Pletcher, S.,  Wakelam, M. J. O. et al.
Nat Metab 1 (11), pp. 1059 - 1073 (2019)