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June 2019

Date Event Place
03rd June 2019
Monday,
10:30am12:00pm
MPI

PhD thesis defense of Tânia Medeiros

Speaker: Tânia Medeiros (Max Planck Institute for Biology of Ageing)
Organizer: Daniela Morick (Max Planck Institute for Biology of Ageing)

Title "Examining the role of autophagy-mediated homeostasis for mitochondrial DNA maintenance"

According to the university regulations, all members of the University of Cologne (lecturers, staff, students) are cordially invited to attend the thesis defence.

Auditorium
MPI for Biology of Ageing
Joseph-Stelzmann Str. 9b
50931 Cologne
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06th June 2019
Thursday,
10:00am11:30am
MPI

PhD thesis defense of David Willemsen

Speaker: David Willemsen (Max Planck Institute for Biology of Ageing)
Organizer: Daniela Morick (Max Planck Institute for Biology of Ageing)

Title "Life history evolution in turquoise killifish"

According to the university regulations, all members of the University of Cologne (lecturers, staff, students) are cordially invited to attend the thesis defence.

Auditorium
MPI for Biology of Ageing
Joseph-Stelzmann Str. 9b
50931 Cologne
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06th June 2019
Thursday,
01:30pm03:00pm
MPI

PhD thesis defense of William John Bradshaw

Speaker: William John Bradshaw (Max Planck Institute for Biology of Ageing)
Organizer: Daniela Morick (Max Planck Institute for Biology of Ageing)

Title "Characterising antibody immunity and ageing in a short-lived teleost"

According to the university regulations, all members of the University of Cologne (lecturers, staff, students) are cordially invited to attend the thesis defence.

Auditorium
MPI for Biology of Ageing
Joseph-Stelzmann Str. 9b
50931 Cologne
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18th June 2019
Tuesday,
04:00pm05:00pm
CSA

Nascent RNA and the coordination of transcription with splicing

Speaker: Karla Neugebauer (USA)
Organizer: Andreas Beyer

There will be wine and cheese and the possibility for further discussion after the talk.

lecture hall, ground floor
CECAD Research Center
Joseph-Stelzmann-Str. 26
Cologne
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21st June 2019
Friday,
11:00am12:00pm
MPI

Talk "Proteome dynamics during brain ageing"

Speaker: Alessandro Cellerino
Organizer: Dario Valenzano

Abstract:

A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegenerative diseases. To investigate this process quantitatively, we characterized proteome dynamics during brain aging by using both the short-lived vertebrate the turquoise killifish, Nothobranchius furzeri and the mouse. In order to obtain quantitative characterization of this processes, we combined transcriptomics, proteomics and thermal proteome profiling. In killifish, we found that the correlation between protein and mRNA levels is progressively reduced during aging, and that post-transcriptional mechanisms are responsible for over 40% of these alterations. These changes induce a progressive stoichiometry loss in protein complexes, including ribosomes, which have low thermal stability in brain lysates and whose component proteins are enriched in aggregates found in old brains. Mechanistically, we show that reduced proteasome activity occurs early during brain aging, and is sufficient to induce loss of stoichiometry. In the mouse, we specifically studied changes of protein and trascripts occurring locally at synaptic level. Protein-transcript decoupling and ribosome aggregation were observed in the isolated synaptic compartment as well. In addition, we observed that synaptic changes during adult life are driven by changes in the soma but during aging we observe decoupling of synapses and soma. Our work thus defines early events in the aging process that can be targeted to prevent loss of protein homeostasis and age-related neurodegeneration.

Auditorium
Max Planck Institute for Biology of Ageing
Joseph-Stelzmann-Str.9b
Cologne
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