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26th September 2019
Targeting the Cell’s Stress Pathways for Therapeutic BenefitSpeaker: Peter Walter (USA)
Organizer: Dusanka Milenkovic
There will be wine and cheese and the possibility for further discussion after the talk.
About the talk:
From leaving their ribosome cradles to their demise in the fangs of proteolytic enzymes, proteins continuously explore different folding states. In most cell compartments, molecular sensors carefully monitor protein folding and instruct downstream effectors to take corrective actions as needed. In response, cells can make adjustments to their protein folding and degradation machineries to stay in a healthy state of homeostasis. If protein folding defects occur and cannot be corrected sufficiently and timely, cells induce suicide programs. Programmed cell death is thought to protect an organism from malfunctioning, rogue cells that result from an accumulation of defective protein. In various pathologies, the life/death balance can inappropriately err on either side: killing cells that would be beneficial if kept alive, or alternatively inappropriately protecting dangerous, disease propagating cells. Studies of the regulation of proteostasis now emerge as focal points of foundational basic research that powerfully connects to a wide spectrum of unmet clinical needs.
Auditorium, ground floor
Max Planck Institute for Biology of Ageing
Cologne Export event