New review about microbiome evolution during host ageing
The human body is inhabited by a large number of microbes. The life of microbes and their host is strongly linked. Francisco Daniel Davila Aléman and Dario Riccardo Valenzano from the Max Planck Institute for Biology of Ageing have now published a mini-review for PLoS Pathogens Pearls describing the fate of the microbiome during host ageing. The review was highlighted by PLoS.
In this paper the scientists propose that ageing of the immune system can lead to host diseases and death. This could happen because of an age-related reduced homeostatic protection from pathogens and by limited capacity to promote beneficial microbes. This situation could in turn lead to the expansion of pathogenic microbes and evolution of evermore pathogenic bacterial strains, with fatal results.
Host ageing may therefore provide opportunities for bacterial evolution, resulting in microbiota-dependent metabolic shifts that could result in host frailty and higher disease risk.
You can read the publication here.