New review about intervening in the ageing process with drugs
Advancing age is a main risk factor for age-related diseases such as cancer, cardiovascular and neurodegenerative diseases. Increasing lifespan also means increasing the occurrence of age-related diseases. Interventions in the ageing process can be made with life style changes but also with certain drugs. Linda Partridge from the Max Planck Institute for Biology of Ageing has now published a review for Nature Reviews Drug Discovery summarizing and analyzing the most promising drug interventions against ageing.
The continuously increasing lifespan is followed by an increase in age-related diseases that burdens the health care sector and threatens economic growth and sustainability. Therefore, new strategies fighting ageing to prevent these diseases, so-called “geroprotection”, are needed. Exercise and diet are lifestyle measures that can impact the ageing process; however, these strategies are not sufficient. Targeted drugs that tackle the underlying cellular processes of ageing may be important future tools to combat the complicated ageing process, by for instance intervening in the nutrient-sensing pathway, removing senescent cells, rejuvenating stem cells and transferring the microbiome. In this paper the scientists describe and discuss the effects of the top candidates for drug intervention and present the latest findings in this field.