Molecular Genetics of Ageing

Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. Yet work from model genetic organisms reveals that animals possess natural defense mechanisms that help stave off ageing, increase organismal homeostasis and stimulate longevity. | more |

Selected publications

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

  • Nakamura, S.
  • Karalay, O.
  • Jager, P. S.
  • Horikawa, M.
  • Klein, C.
  • Nakamura, K.
  • Latza, C.
  • Templer, S. E.
  • Dieterich, C.
  • Antebi, A.
(2016) Nat Commun, 7, 10944

Co-chaperone p23 regulates C. elegans Lifespan in Response to Temperature

  • Horikawa, M.
  • Sural, S.
  • Hsu, A. L.
  • Antebi, A.
(2015) PLoS Genet, 11, 4, e1005023

Hexosamine pathway and (ER) protein quality control

  • Denzel, M. S.
  • Antebi, A.
(2015) Curr Opin Cell Biol, 33, 14-8

DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation

  • Horn, M.
  • Geisen, C.
  • Cermak, L.
  • Becker, B.
  • Nakamura, S.
  • Klein, C.
  • Pagano, M.
  • Antebi, A.
(2014) Dev Cell, 28, 6, 697-710

The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans

  • Magner, D. B.
  • Wollam, J.
  • Shen, Y.
  • Hoppe, C.
  • Li, D.
  • Latza, C.
  • Rottiers, V.
  • Hutter, H.
  • Antebi, A.
(2013) Cell Metab, 18, 2, 212-24

Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans

  • Heestand, B. N.
  • Shen, Y.
  • Liu, W.
  • Magner, D. B.
  • Storm, N.
  • Meharg, C.
  • Habermann, B.
  • Antebi, A.
(2013) PLoS Genet, 9, 7, e1003651

Third-party funding

  • 2015-2018 | BMBF EndoProtect
    Subproject 1

  • 2013-2017 | DFG
    CECAD: EXC 229 - to support collaborative research

  • 2011-2015 | BMBF
    GERONTOSYS - Forschungskern: SyBACol (Systems Biology of Ageing Cologne); Project Area A: Systems Biology of Longevity Pathways; Subproject B

  • 2011-2015 | DFG
    SFB 635: Posttranslational control of protein function, Project C9: Regulation of C. elegans Developmental Timing by the F-box Protein  DRE-1/FBXO11

  • 2011-2012 | DFG
    CECAD Project: Metabolomic Profiling of C. elegans Longevity