The group of Nils-Göran Larsson focuses on mitochondrial genetics and the impact of mitochondrial dysfunction on disease and ageing.
Mitochondrial dysfunction is heavily implicated in the ageing process. Ageing humans have increased levels of somatic mutations in the mitochondrial genome that tend to undergo clonal expansion to cause mosaic deficiencies in the respiratory chain. The oxidative phosphorylation (OXPHOS) system produces adenosine triphosphate (ATP), the universal source of energy in all tissues. Respiratory chain dysfunction, and thus insufficient supply of ATP, can cause a variety of phenotypes associated with ageing, age-related- and mitochondrial diseases. | more |
2015 | DFG
CECAD: EXC 229 - to support collaborative research
2011-2016 | European Research Council (ERC) FP7, Advanced Gran
Genemit: Regulation of gene expression in mammalian mitochondria
2009-2016 | DFG
SFB829: Molecular mechanisms regulating skin homeostasis