Research Group Pernas

The metabolism of infection

The metabolism of a cell, i.e. the processes that store, break down, utilize, import, and export metabolites, stand between an intracellular pathogen and the nutrients it needs to grow. We study the role of host metabolism in the cellular response to infection using Toxoplasma gondii as a model pathogen. Ageing has profound effects on metabolism and the response to microbial infection and therefore provides an optimal angle to begin dissecting these inputs. Ultimately, we hope to better understand how human metabolism influences the progression of infectious disease.

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