RESEARCH GROUP STEWART

Research Group Stewart is currently not accepting applications for graduate students.

Genome Evolution and Ageing

Since the 1970's the involvement of mitochondria in the ageing process has been recognized. As we age, there is clear evidence of the accumulation of a mosaic pattern of cells from different tissues that are deficient in the enzymatic capacity of the mitochondrial respiratory chain. Much of the research attention has focused on either the action of radical oxygen species, or the accumulation of somatic mutations and/or chromosomal rearrangements in mitochondrial DNA and their physiological effects. However, new hypotheses on the unusual evolutionary balance between the nuclear and mitochondrial genome are being investigated, which may have implication on the ageing process.

Selected publications

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

Kauppila, J. H.
Baines, H. L.
Bratic, A.
Simard, M. L.
Freyer, C.
Mourier, A.
Stamp, C.
Filograna, R.
Larsson, N. G.
Greaves, L. C.
Stewart, J. B.

(2016) Cell Rep, 16, 11, 2980-90

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

Stewart, J. B.
Chinnery, P. F.

(2015) Nat Rev Genet, 16, 9, 530-42

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

Stewart, J. B.
Alaei-Mahabadi, B.
Sabarinathan, R.
Samuelsson, T.
Gorodkin, J.
Gustafsson, C. M.
Larsson, E.

(2015) PLoS Genet, 11, 6, e1005333

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Ross, J. M.*
Stewart, J. B.*
Hagstrom, E.
Brene, S.
Mourier, A.
Coppotelli, G.
Freyer, C.
Lagouge, M.
Hoffer, B. J.
Olson, L.
Larsson, N. G.

(2013) Nature, 501, 7467, 412-5

Third-party funding

2016-2019 | Marie Skłodowska-Curie Action, Innovation Training Network
REgulation of MItochondrial gene eXpression (REMIX)

2013-2015 | United Mitochondrial Disease Foundation Research Grant
Using mtDNA mutator mouse-derived lineages to generate mouse models of human mitochondrial diseases

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