MAX PLANCK RESEARCH GROUP WICKSTRÖM

Paul Gerson Unna Research Group by the Max Planck Society

This group is one of three Paul Gerson Unna Research Groups within the Max-Planck-Society, kindly funded by the Max und Ingeburg Herz-Foundation with the support of the Max-Planck-Foundation.

We are looking for a candidate for a Master thesis position in stem cell biology.

Please send your application including a short motivation letter, CV, and transcript of
records to Dr. Chacón-Martínez latest by 23.01.2017.
Informal inquiries are also welcome.

Skin Homeostasis and Ageing

Adult tissue-resident stem cells fuel renewal, repair, and remodeling of tissues to maintain their structure and function. Our research aims to uncover how single stem cell behaviors are coordinated at the population level, and how population-level dynamics are coupled to tissue architecture. Uncovering these regulatory principles will facilitate the development of stem cell and regenerative therapies and more effective treatments against cancers. As a self-renewing organ maintained by multiple distinct stem cell populations, the skin epidermis represents an outstanding, clinically highly relevant research paradigm to address these question.

Our research focuses on 3 main areas:

  1. Role of stem cell-niche interactions in fate decisions and phenotypic plasticity

  2. Biomechanics of epidermal morphogenesis, homeostasis and ageing

  3. Regulation of nuclear and genomic architecture, gene expression, and SC fate by mechanotransduction

Click here to find out more about our research...

Selected publications

1.    Chacón-Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA. (2016). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBOJ. In press

2.    Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 18, 864-875. Highlighted by Nature Reviews Molecular Cell Biology, Faculty of 1000

3.    Morgner, J., Ghatak, S., Jakobi, T., Dieterich, C., Aumailley, M., Wickström, S.A. (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 6:8198

4.    Radovanac, K.*, Morgner, J.*, Schultz, J.N., Blumbach, K., Patterson, C., Geiger, T., Mann, M., Krieg, T., Eckes, B., Fässler, R., Wickström, S.A. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBOJ. 32, 1409-1424. *Equal contribution

5.    Wickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R. (2010). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell. 19, 574-588. *Corresponding author; Highlighted by Faculty of 1000 and Nature Reviews Molecular Cell Biology

Third-party funding

  • 2010 - current | Paul Gerson Unna Research group
    This group is one of three Paul Gerson Unna Research Groups within the Max-Planck-Society, kindly funded by the Max und Ingeburg Herz-Foundation with the support of the Max-Planck-Foundation. Project in a nutshell...

  • 2015-2017 | DFG
    Role of Integrin-linked kinase in skin homeostasis and carcinogenesis

  • 2017-2020 | DFG
    Regulation of epidermal stratification and homeostasis through contractility and density sensing, German Research Foundation (DFG; SFB 829)

  • 2015-2017 | DFG
    Role of Integrin-linked kinase in skin homeostasis and carcinogenesis, German Research Foundation (DFG; WI 4177)

  • 2013-2016 | DFG
    Regulation of epidermal stratification and homeostasis through contractility and density sensing, German Research Foundation (DFG; SFB 829)