Max Planck Research Group Wickström
Paul Gerson Unna Research Group by the Max Planck Society
This group is one of three Paul Gerson Unna Research Groups within the Max-Planck-Society, kindly funded by the Max und Ingeburg Herz-Foundation with the support of the Max-Planck-Foundation.
Skin Homeostasis and Ageing
The physiological process that maintains a constant number of cells in a renewing organ is called tissue homeostasis. The mammalian skin is ideal for investigating the mechanisms of this process, as it undergoes self-renewal throughout the lifetime of the organism. Our research addresses two fundamental questions: What are the basic principles that govern the balance of proliferation and differentiation enable the maintenance of the skin as a robust but continuously self-renewing organ? How do the dynamics of this balance change upon ageing resulting in tissue dysfunction and disease? [more...]
Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol 18, 864-875.
Morgner J., Ghatak S., Jakobi T., Dieterich C., Aumailley M., Wickström S.A. (2015) Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun 6:8198
Radovanac, K.*, Morgner, J.*, Schultz, J.N., Blumbach, K., Patterson, C., Geiger, T., Mann, M., Krieg, T., Eckes, B., Fässler, R., Wickström, S.A. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBOJ. doi:10.1038/emboj.2013.90 *Equal contribution
Wickström, S.A.*, Lange, A., Hess, M.W., Polleux, J., Spatz, J.P., Kruger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., et al. (2010). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell 19, 574-588.
* Corresponding author
Lange, A., Wickström, S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461, 1002-1006.
- 2010 - current | Paul Gerson Unna Research group
This group is one of three Paul Gerson Unna Research Groups within the Max-Planck-Society, kindly funded by the Max und Ingeburg Herz-Foundation with the support of the Max-Planck-Foundation. Project in a nutshell...
- 2015-2017 | DFG
Role of Integrin-linked kinase in skin homeostasis and carcinogenesis
- 2013-2016 | DFG
SFB 829: Molecular mechanisms regulating skin homeostasis - Subproject A11: Regulation of epidermal stratification and homeostasis through contractility and density sensing
- 2013-2015 | Behrens-Weise Foundation
Role of rigidity sensing in skin homeostasis and aging
- 2012-2015 | NRW Academy of Arts and Sciences/ Stiftung Mercator
Skin homeostasis and ageing