Cologne Seminars on Ageing "Rewiring of organelle dynamics & cell metabolism by signaling lipids"
- Datum: 01.06.2023
- Uhrzeit: 13:00 - 14:00
- Vortragender: Volker Haucke
- Ort: MPI for Biology of Ageing
- Raum: Auditorium
- Gastgeber: Natalia Kononenko (CECAD)
About Dr. Hauckes talk:
Cells respond to stress or altering nutrient supply by adaptive changes in organelle dynamics and in metabolism. In my talk I will focus on the role of signaling lipids and ions in orchestrating these changes, e.g. by eliciting transcriptional responses and the formation or dissolution of contact sites that facilitate the direct exchange of molecules between organelles. For example, I will cover our recent advances in the analysis of the metabolic pathways that regulate the cellular synthesis and turnover of distinct phosphatidylinositol 3-phosphates at endosomes or lysosomes in response to altering nutrient conditions, discuss the mechanisms by which these lipids regulate endolysosomal membrane dynamics and metabolism, and provide examples of how dysregulation of these pathways may cause human disease or be altered in aging.