Cologne Seminars on Ageing "Evolution and system-scale nature of metabolism"

About Dr. Ralser´s talk:
Life runs on many thousands of different chemical reactions, known collectively as cell metabolism.
Metabolic reactions are vital for keeping cells and organisms growing and alive, and problems with cellular metabolism are implicated in ageing and diseases such as cancer, diabetes and brain disorders. Rather than thinking about cell metabolism as a collection of individual reactions, we are working to understand metabolism as a dynamic, interconnected network of processes that adapts in response to changes and stresses in the environment, and that evolves and functions as an entity.
In this lecture, I’ll summarize our efforts of conducting hundreds to thousands of analytical measurements at both proteome and metabolome, allowing us to study how these complex metabolic processes are controlled, and how they are reconfigured in response to environmental changes. By taking detailed precision measurements of the genes and molecules involved in metabolic processes and putting the data into computer analysis programmes, we can trace how the cell’s metabolism adapts and changes in response to various stresses and strains. I'll present our results in which we used synthetic and natural yeast communities, to study how metabolite exchange interactions between cells affect their lifespan.