Publikationen von T. Langer

Korwitz, A.; Merkwirth, C.; Richter-Dennerlein, R.; Troder, S. E.; Sprenger, H.-G.; Quiros, P. M.; Lopez-Otin, C.; Rugarli, E. I.; Langer, T.: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol 212 (2), S. 157 - 66 (2016)

Wai, T.; Garcia-Prieto, J.; Baker, M. J.; Merkwirth, C.; Benit, P.; Rustin, P.; Ruperez, F. J.; Barbas, C.; Ibanez, B.; Langer, T.: Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science 350 (6265), S. aad0116 (2016)

Wai, T.; Langer, T.: Mitochondrial Dynamics and Metabolic Regulation. Trends Endocrinol Metab 27 (2), S. 105 - 17 (2016)

Klecker, T.; Wemmer, M.; Haag, M.; Weig, A.; Bockler, S.; Langer, T.; Nunnari, J.; Westermann, B.: Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Sci Rep 5, S. 18344 (2015)

Moncunill-Massaguer, C.; Saura-Esteller, J.; Perez-Perarnau, A.; Palmeri, C. M.; Nunez-Vazquez, S.; Cosialls, A. M.; Gonzalez-Girones, D. M.; Pomares, H.; Korwitz, A.; Preciado, S. et al.; Albericio, F.; Lavilla, R.; Pons, G.; Langer, T.; Iglesias-Serret, D.; Gil, J.: A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget 6 (39), S. 41750 - 65 (2015)

Miliara, X.; Garnett, J. A.; Tatsuta, T.; Abid Ali, F.; Baldie, H.; Perez-Dorado, I.; Simpson, P.; Yague, E.; Langer, T.; Matthews, S.: Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep 16 (7), S. 824 - 35 (2015)

Quiros, P. M.; Langer, T.; Lopez-Otin, C.: New roles for mitochondrial proteases in health, ageing and disease. Nat Rev Mol Cell Biol 16 (6), S. 345 - 59 (2015)

Mancini, C.; Orsi, L.; Guo, Y.; Li, J.; Chen, Y.; Wang, F.; Tian, L.; Liu, X.; Zhang, J.; Jiang, H. et al.; Nmezi, B. S.; Tatsuta, T.; Giorgio, E.; Di Gregorio, E.; Cavalieri, S.; Pozzi, E.; Mortara, P.; Caglio, M. M.; Balducci, A.; Pinessi, L.; Langer, T.; Padiath, Q. S.; Hakonarson, H.; Zhang, X.; Brusco, A.: An atypical form of AOA2 with myoclonus associated with mutations in SETX and AFG3L2. BMC Med Genet 16, S. 16 (2015)

Mitsopoulos, P.; Chang, Y. H.; Wai, T.; Konig, T.; Dunn, S. D.; Langer, T.; Madrenas, J.: Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mol Cell Biol 35 (10), S. 1838 - 47 (2015)

Bahat, A.; Perlberg, S.; Melamed-Book, N.; Isaac, S.; Eden, A.; Lauria, I.; Langer, T.; Orly, J.: Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR). Mol Cell Endocrinol 408, S. 62 - 72 (2015)

Kehrein, K.; Schilling, R.; Moller-Hergt, B. V.; Wurm, C. A.; Jakobs, S.; Lamkemeyer, T.; Langer, T.; Ott, M.: Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Cell Rep 10 (6), S. 843 - 853 (2015)

Ising, C.; Koehler, S.; Brahler, S.; Merkwirth, C.; Hohne, M.; Baris, O. R.; Hagmann, H.; Kann, M.; Fabretti, F.; Dafinger, C. et al.; Bloch, W.; Schermer, B.; Linkermann, A.; Bruning, J. C.; Kurschat, C. E.; Muller, R. U.; Wiesner, R. J.; Langer, T.; Benzing, T.; Brinkkoetter, P. T.: Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med 7 (3), S. 275 - 87 (2015)

Richter-Dennerlein, R.; Korwitz, A.; Haag, M.; Tatsuta, T.; Dargazanli, S.; Baker, M.; Decker, T.; Lamkemeyer, T.; Rugarli, E. I.; Langer, T.: DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metab 20 (1), S. 158 - 71 (2014)

Almontashiri, N. A.; Chen, H. H.; Mailloux, R. J.; Tatsuta, T.; Teng, A. C.; Mahmoud, A. B.; Ho, T.; Stewart, N. A.; Rippstein, P.; Harper, M. E. et al.; Roberts, R.; Willenborg, C.; Erdmann, J.; Consortium, C. A.; Pastore, A.; McBride, H. M.; Langer, T.; Stewart, A. F.: SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes. Cell Rep 7 (3), S. 834 - 47 (2014)

Kondadi, A. K.; Wang, S.; Montagner, S.; Kladt, N.; Korwitz, A.; Martinelli, P.; Herholz, D.; Baker, M. J.; Schauss, A. C.; Langer, T. et al.; Rugarli, E. I.: Loss of the m-AAA protease subunit AFG(3)L(2) causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J 33 (9), S. 1011 - 26 (2014)

Anand, R.; Wai, T.; Baker, M. J.; Kladt, N.; Schauss, A. C.; Rugarli, E.; Langer, T.: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 204 (6), S. 919 - 29 (2014)

Escobar-Henriques , M.; Langer, T.: Dynamic survey of mitochondria by ubiquitin. EMBO Rep 15 (3), S. 231 - 43 (2014)

Sepulveda-Falla, D.; Barrera-Ocampo, A.; Hagel, C.; Korwitz, A.; Vinueza-Veloz, M. F.; Zhou, K.; Schonewille, M.; Zhou, H.; Velazquez-Perez, L.; Rodriguez-Labrada, R. et al.; Villegas, A.; Ferrer, I.; Lopera, F.; Langer, T.; De Zeeuw, C. I.; Glatzel, M.: Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest 124 (4), S. 1552 - 67 (2014)

Baker, M. J.; Lampe, P. A.; Stojanovski, D.; Korwitz, A.; Anand, R.; Tatsuta, T.; Langer, T.: Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J 33 (6), S. 578 - 93 (2014)

Bahat, A.; Perlberg, S.; Melamed-Book, N.; Lauria, I.; Langer, T.; Orly, J.: StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation. Mol Endocrinol 28 (2), S. 208 - 24 (2014)