Chromatin und Altern
Chromatin is the complex of DNA and proteins that can be found in the nucleus of a cell. We are very interested in understanding how the architecture of chromatin can regulate gene expression. In particular, we aim to elucidate how age-related changes in the epigenome influence transcriptional outputs and ultimately, cellular fate decisions. Over the recent years, we became fascinated by the connection of other cellular pathways with epigenetic mechanisms and have expanded our research to address the connection between metabolism and inter-organellar communication on chromatin architecture. To this end we combine mechanistic approaches in S. cerevisiae and established cell culture systems with analysis of primary cells and tissues using biochemistry, cell biology and a variety of state-of-the art deep sequencing technologies.