Constantinos Demetriades, PhD (he/him)

Lebenslauf

Wissenschaftlicher Werdegang

2019 - heute    |    CECAD Associated Principal Investigator
CECAD Research Center, Universität Köln, Deutschland
2017 - heute    |    Max Planck Forschungsgruppenleiter (Assoc. Prof. level)
Max Planck Institut für Biologe des Alterns, Köln, Deutschland
2010 - 2016    |    Postdoctoral Researcher
Division of Signal Transduction in Cancer and Metabolism, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland (mit Aurelio Teleman)
2006 - 2009    |    Ph.D. Research Associate
Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki, Griechenland (mit George Mosialos)
2003 - 2006    |    Ph.D. Fellow
Institute of Immunology, Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Athen, Griechenland (mit George Mosialos)
2002 - 2003    |    Senior undergraduate thesis
Laboratory of Developmental Biology, Aristotle University of Thessaloniki, Griechenland (mit Margarita Hadzopoulou-Cladaras)

Ausbildung

2003 - 2009    |    Promotion (Ph.D.)
2003 - 2006: Institute of Immunology, Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Athen, Griechenland
2006 - 2009: Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki, Griechenland
1999 - 2003    |    Studium (Ptychion) der Biologie
School of Biology, Aristotle University of Thessaloniki, Griechenland

Drittmittel-Projekte

2022 - 2025    |    Research Unit FOR2722 Grant - Deutsche Forschungsgesellschaft (DFG)
2019 - 2022    |    Heineman Project Grant - Minna-James-Heineman Foundation & Minerva Foundation
2018 - 2023    |    ERC Starting Grant - European Research Council (ERC-StG-2017)

Preise / Auszeichnungen

2019    |    Walther Flemming Award - Deutsche Gesellschaft für Zellbiologie (DGZ)
2014    |    Fellowship - 14th FEBS Young Scientists` Forum (YSF), August 2014, Paris, France
2011    |    Award from the Alexander S. Onassis Public Benefit Foundation and nomination to attend the 61st Lindau Nobel Laureate Meeting, Lindau, Germany
2004 - 2005    |    Research Scholarship - Postgraduate Program of the Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Griechenland
2001 - 2002    |    Scholarship and Prize - State Scholarships Foundation (S.S.F.) of Greece for excellence as an undergraduate student of the School of Biology, Aristotle University of Thessaloniki, Griechenland

Ausgewählte Publikationen

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
Nicastro, R., Brohée, L., Alba, J., Nüchel, J., Figlia, G., Kipschull, S., Gollwitzer, P., Romero-Pozuelo, J., Fernandes, S.A., Lamprakis, A., Vanni, S., Teleman, A.A., De Virgilio, C., Demetriades, C.
(2023) Nat Cell Biol

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
Gollwitzer, P., Grützmacher, N., Wilhelm, S., Kümmel, D., Demetriades, C.
(2022) Nat Cell Biol

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
Nuechel, J., Tauber, M., Nolte, J. L., Morgelin, M., Turk, C., Eckes, B., Demetriades, C., Plomann, M.
(2021) Mol Cell, 81, 16, 3275-3293

Lysosomal recruitment of TSC2 is a universal response to cellular stress
Demetriades C., Plescher M., and Teleman AA.,
(2016) Nature Communications; 7:10662.

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
Demetriades C., Doumpas N., and Teleman AA.,
(2014) Cell.; 156(4):786-99.

Vollständige Publikationsliste unter https://www.age.mpg.de/demetriades/publikationen