Abteilung Partridge

Publikationen

Biological mechanisms of aging predict age-related disease co-occurrence in patients

  • Fraser, H. C.
  • Kuan, V.
  • Johnen, R.
  • Zwierzyna, M.
  • Hingorani, A. D.
  • Beyer, A.
  • Partridge, L.
(2022) Aging Cell, e13524

Meeting Report: Aging Research and Drug Discovery

  • Meron, E.
  • Thaysen, M.
  • Angeli, S.
  • Antebi, A.
  • Barzilai, N.
  • Baur, J. A.
  • Bekker-Jensen, S.
  • Birkisdottir, M.
  • Bischof, E.
  • Bruening, J.
  • Brunet, A.
  • Buchwalter, A.
  • Cabreiro, F.
  • Cai, S.
  • Chen, B. H.
  • Ermolaeva, M.
  • Ewald, C. Y.
  • Ferrucci, L.
  • Florian, M. C.
  • Fortney, K.
  • Freund, A.
  • Georgievskaya, A.
  • Gladyshev, V. N.
  • Glass, D.
  • Golato, T.
  • Gorbunova, V.
  • Hoejimakers, J.
  • Houtkooper, R. H.
  • Jager, S.
  • Jaksch, F.
  • Janssens, G.
  • Jensen, M. B.
  • Kaeberlein, M.
  • Karsenty, G.
  • de Keizer, P.
  • Kennedy, B.
  • Kirkland, J. L.
  • Kjaer, M.
  • Kroemer, G.
  • Lee, K. F.
  • Lemaitre, J. M.
  • Liaskos, D.
  • Longo, V. D.
  • Lu, Y. X.
  • MacArthur, M. R.
  • Maier, A. B.
  • Manakanatas, C.
  • Mitchell, S. J.
  • Moskalev, A.
  • Niedernhofer, L.
  • Ozerov, I.
  • Partridge, L.
  • Passegue, E.
  • Petr, M. A.
  • Peyer, J.
  • Radenkovic, D.
  • Rando, T. A.
  • Rattan, S.
  • Riedel, C. G.
  • Rudolph, L.
  • Ai, R.
  • Serrano, M.
  • Schumacher, B.
  • Sinclair, D. A.
  • Smith, R.
  • Suh, Y.
  • Taub, P.
  • Trapp, A.
  • Trendelenburg, A. U.
  • Valenzano, D. R.
  • Verburgh, K.
  • Verdin, E.
  • Vijg, J.
  • Westendorp, R. G. J.
  • Zonari, A.
  • Bakula, D.
  • Zhavoronkov, A.
  • Scheibye-Knudsen, M.
(2022) Aging (Albany NY), 14, 2, 530-543

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

  • Baghdadi, M.
  • Hinterding, H. M
  • Partridge, L.
  • Deelen, J.
(2022) Briefings in Functional Genomics, 1, 25, 13-23

Lithium can mildly increase health during ageing but not lifespan in mice

  • Nespital, T.
  • Neuhaus, B.
  • Mesaros, A.
  • Pahl, A.
  • Partridge, L.
(2021) Aging Cell, 10, 20, e13479

A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation

  • Li, L.
  • Conradson, D. M.
  • Bharat, V.
  • Kim, M. J.
  • Hsieh, C. H.
  • Minhas, P. S.
  • Papakyrikos, A. M.
  • Durairaj, A. S.
  • Ludlam, A.
  • Andreasson, K. I.
  • Partridge, L.
  • Cianfrocco, M. A.
  • Wang, X.
(2021) Nat Metab, 9, 3, 1242-1258

Functional conservation in genes and pathways linking ageing and immunity

  • Fabian, D. K.
  • Fuentealba, M.
  • Donertas, H. M.
  • Partridge, L.
  • Thornton, J. M.
(2021) Immun Ageing, 18, 1, 23

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

  • Lu, Y. X.
  • Regan, J. C.
  • Esser, J.
  • Drews, L. F.
  • Weinseis, T.
  • Stinn, J.
  • Hahn, O.
  • Miller, R. A.
  • Gronke, S.
  • Partridge, L.
(2021) Elife, 10

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity

  • Niccoli, T.
  • Kerr, F.
  • Snoeren, I.
  • Fabian, D.
  • Aleyakpo, B.
  • Ivanov, D.
  • Sofola-Adesakin, O.
  • Cryar, A.
  • Adcott, J.
  • Thornton, J.
  • Partridge, L.
(2021) Brain Commun, 3, 2, fcab053

Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults

  • Dzankic, P. J.
  • Partridge, L.
(2021) Lancet Healthy Longev, 2, 5, e232-e233

Common genetic associations between age-related diseases

  • Donertas, H. M.
  • Fabian, D. K.
  • Valenzuela, M. F.
  • Partridge, L.
  • Thornton, J. M.
(2021) Nat Aging, 1, 4, 400-412

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

  • Tain, L. S.
  • Sehlke, R.
  • Meilenbrock, R. L.
  • Leech, T.
  • Paulitz, J.
  • Chokkalingam, M.
  • Nagaraj, N.
  • Gronke, S.
  • Frohlich, J.
  • Atanassov, I.
  • Mann, M.
  • Beyer, A.
  • Partridge, L.
(2021) Elife, 10

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

  • Atilano, M. L.
  • Gronke, S.
  • Niccoli, T.
  • Kempthorne, L.
  • Hahn, O.
  • Moron-Oset, J.
  • Hendrich, O.
  • Dyson, M.
  • Adams, M. L.
  • Hull, A.
  • Salcher-Konrad, M. T.
  • Monaghan, A.
  • Bictash, M.
  • Glaria, I.
  • Isaacs, A. M.
  • Partridge, L.
(2021) Elife, 10

FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity

  • Kapetanou, M.
  • Nespital, T.
  • Tain, L. S.
  • Pahl, A.
  • Partridge, L.
  • Gonos, E. S.
(2021) Front Cell Dev Biol, 9, 625715

Transposable element landscape in Drosophila populations selected for longevity

  • Fabian, D. K.
  • Melike Donertas, H.
  • Fuentealba, M.
  • Partridge, L.
  • Thornton, J. M.
(2021) Genome Biol Evol, 13, 4, evab031

Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system

  • Bolukbasi, E.
  • Woodling, N. S.
  • Ivanov, D. K.
  • Adcott, J.
  • Foley, A.
  • Rajasingam, A.
  • Gittings, L. M.
  • Aleyakpo, B.
  • Niccoli, T.
  • Thornton, J. M.
  • Partridge, L.
(2021) Proc Natl Acad Sci U S A, 118, 8

A neuronal blood marker is associated with mortality in old age

  • Kaeser, S. A.
  • Lehallier, B.
  • Thinggaard, M.
  • Häsler, L.M.
  • Apel, A.
  • Bergmann, C.
  • Berdnik, D.
  • Jeune, B.
  • Christensen, K.
  • Grönke, S.
  • Partridge, L.
  • Wyss-Coray, T.
  • Mengel-From, J.
  • Jucker, M.
(2021) Nature Aging, 1, 2, 218-225

Data-driven identification of ageing-related diseases from electronic health records

  • Kuan, V.
  • Fraser, H. C.
  • Hingorani, M.
  • Denaxas, S.
  • Gonzalez-Izquierdo, A.
  • Direk, K.
  • Nitsch, D.
  • Mathur, R.
  • Parisinos, C. A.
  • Lumbers, R. T.
  • Sofat, R.
  • Wong, I. C. K.
  • Casas, J. P.
  • Thornton, J. M.
  • Hemingway, H.
  • Partridge, L.
  • Hingorani, A. D.
(2021) Sci Rep, 11, 1, 2938

Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults

  • Cox, L. S.
  • Bellantuono, I.
  • Lord, J. M.
  • Sapey, E.
  • Mannick, J. B.
  • Partridge, L.
  • Gordon, A. L.
  • Steves, C. J.
  • Witham, M. D.
(2021) Lancet Healthy Longev, 1, 2, e55-e57

Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids

  • Lu, J.
  • Temp, U.
  • Müller-Hartmann, A.
  • Esser, J.
  • Grönke, S.
  • Partridge, L.
(2021) Nature Aging, 1, 1, 60-72

Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

  • Fuentealba, M.
  • Fabian, D. K.
  • Donertas, H. M.
  • Thornton, J. M.
  • Partridge, L.
(2021) Mech Ageing Dev, 194, 111437

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

  • Bjedov, I.
  • Cocheme, H. M.
  • Foley, A.
  • Wieser, D.
  • Woodling, N. S.
  • Castillo-Quan, J. I.
  • Norvaisas, P.
  • Lujan, C.
  • Regan, J. C.
  • Toivonen, J. M.
  • Murphy, M. P.
  • Thornton, J.
  • Kinghorn, K. J.
  • Neufeld, T. P.
  • Cabreiro, F.
  • Partridge, L.
(2020) PLoS Genet, 16, 11, e1009083

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

  • Woodling, N. S.
  • Rajasingam, A.
  • Minkley, L. J.
  • Rizzo, A.
  • Partridge, L.
(2020) BMC Biol, 18, 1, 124

The quest to slow ageing through drug discovery

  • Partridge, L.
  • Fuentealba, M.
  • Kennedy, B. K.
(2020) Nat Rev Drug Discov, 19, 8, 513-532

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

  • Weigelt, C. M.
  • Sehgal, R.
  • Tain, L. S.
  • Cheng, J.
  • Esser, J.
  • Pahl, A.
  • Dieterich, C.
  • Gronke, S.
  • Partridge, L.
(2020) Mol Cell, 79, 2, 268-279 e5

PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity

  • Yu, Y.
  • Niccoli, T.
  • Ren, Z.
  • Woodling, N. S.
  • Aleyakpo, B.
  • Szabadkai, G.
  • Partridge, L.
(2020) Hum Mol Genet, 29, 14, 2420-2434

The neuronal receptor tyrosine kinase Alk is a target for longevity

  • Woodling, N. S.
  • Aleyakpo, B.
  • Dyson, M. C.
  • Minkley, L. J.
  • Rajasingam, A.
  • Dobson, A. J.
  • Leung, K. H. C.
  • Pomposova, S.
  • Fuentealba, M.
  • Alic, N.
  • Partridge, L.
(2020) Aging Cell, 19, 5, e13137

Long-term in vivo imaging of Drosophila larvae

  • Kakanj, P.
  • Eming, S. A.
  • Partridge, L.
  • Leptin, M.
(2020) Nat Protoc, 15, 3, 1158-1187

Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production

  • Tain, L. S.
  • Jain, C.
  • Nespital, T.
  • Froehlich, J.
  • Hinze, Y.
  • Gronke, S.
  • Partridge, L.
(2020) Aging Cell, 19, 1, e13043

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

  • Moron-Oset, J.
  • Super, T.
  • Esser, J.
  • Isaacs, A. M.
  • Gronke, S.
  • Partridge, L.
(2019) Acta Neuropathol Commun, 7, 1, 209

A nutritional memory effect counteracts benefits of dietary restriction in old mice

  • Hahn, O.
  • Drews, L. F.
  • Nguyen, A.
  • Tatsuta, T.
  • Gkioni, L.
  • Hendrich, O.
  • Zhang, Q.
  • Langer, T.
  • Pletcher, S.
  • Wakelam, M. J. O.
  • Beyer, A.
  • Gronke, S.
  • Partridge, L.
(2019) Nat Metab, 1, 11, 1059-1073

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

  • Castillo-Quan, J. I.
  • Tain, L. S.
  • Kinghorn, K. J.
  • Li, L.
  • Gronke, S.
  • Hinze, Y.
  • Blackwell, T. K.
  • Bjedov, I.
  • Partridge, L.
(2019) Proc Natl Acad Sci U S A, 116, 42, 20817-20819

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

  • Yamada, S. B.
  • Gendron, T. F.
  • Niccoli, T.
  • Genuth, N. R.
  • Grosely, R.
  • Shi, Y.
  • Glaria, I.
  • Kramer, N. J.
  • Nakayama, L.
  • Fang, S.
  • Dinger, T. J. I.
  • Thoeng, A.
  • Rocha, G.
  • Barna, M.
  • Puglisi, J. D.
  • Partridge, L.
  • Ichida, J. K.
  • Isaacs, A. M.
  • Petrucelli, L.
  • Gitler, A. D.
(2019) Nat Neurosci, 22, 9, 1383-1388

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

  • Solon-Biet, S. M.
  • Cogger, V. C.
  • Pulpitel, T.
  • Wahl, D.
  • Clark, X.
  • Bagley, E.
  • Gregoriou, G. C.
  • Senior, A. M.
  • Wang, Q. P.
  • Brandon, A. E.
  • Perks, R.
  • O'Sullivan, J.
  • Koay, Y. C.
  • Bell-Anderson, K.
  • Kebede, M.
  • Yau, B.
  • Atkinson, C.
  • Svineng, G.
  • Dodgson, T.
  • Wali, J. A.
  • Piper, M. D. W.
  • Juricic, P.
  • Partridge, L.
  • Rose, A. J.
  • Raubenheimer, D.
  • Cooney, G. J.
  • Le Couteur, D. G.
  • Simpson, S. J.
(2019) Nat Metab, 1, 5, 532-545

A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster

  • Augustin, H.
  • Zylbertal, A.
  • Partridge, L.
(2019) eNeuro, 6, 2

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A

  • Moens, T. G.
  • Niccoli, T.
  • Wilson, K. M.
  • Atilano, M. L.
  • Birsa, N.
  • Gittings, L. M.
  • Holbling, B. V.
  • Dyson, M. C.
  • Thoeng, A.
  • Neeves, J.
  • Glaria, I.
  • Yu, L.
  • Bussmann, J.
  • Storkebaum, E.
  • Pardo, M.
  • Choudhary, J. S.
  • Fratta, P.
  • Partridge, L.
  • Isaacs, A. M.
(2019) Acta Neuropathol, 137, 3, 487-500

Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster

  • Weigelt, C. M.
  • Hahn, O.
  • Arlt, K.
  • Gruhn, M.
  • Jahn, A. J.
  • Esser, J.
  • Werner, J. A.
  • Klein, C.
  • Buschges, A.
  • Gronke, S.
  • Partridge, L.
(2019) Life Sci Alliance, 2, 1

Identifying Potential Ageing-Modulating Drugs In Silico

  • Donertas, H. M.
  • Fuentealba, M.
  • Partridge, L.
  • Thornton, J. M.
(2019) Trends Endocrinol Metab, 30, 2, 118-131

Using the drug-protein interactome to identify anti-ageing compounds for humans

  • Fuentealba, M.
  • Donertas, H. M.
  • Williams, R.
  • Labbadia, J.
  • Thornton, J. M.
  • Partridge, L.
(2019) PLoS Comput Biol, 15, 1, e1006639

Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila

  • Juricic, P.
  • Gronke, S.
  • Partridge, L.
(2019) J Gerontol A Biol Sci Med Sci, 75, 1, 24-31

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

  • Hahn, O.
  • Stubbs, T. M.
  • Reik, W.
  • Gronke, S.
  • Beyer, A.
  • Partridge, L.
(2018) PLoS Genet, 14, 11, e1007766

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

  • Kauppila, T. E. S.
  • Bratic, A.
  • Jensen, M. B.
  • Baggio, F.
  • Partridge, L.
  • Jasper, H.
  • Gronke, S.
  • Larsson, N. G.
(2018) Proc Natl Acad Sci U S A, 115, 41, E9620-E9629

Facing up to the global challenges of ageing

  • Partridge, L.
  • Deelen, J.
  • Slagboom, P. E.
(2018) Nature, 561, 7721, 45-56

Horizons in the evolution of aging

  • Flatt, T.
  • Partridge, L.
(2018) BMC Biol, 16, 1, 93

Gene Expression-Based Drug Repurposing to Target Ageing

  • Donertas, H. M.
  • Fuentealba Valenzuela, M.
  • Partridge, L.
  • Thornton, J. M.
(2018) Aging Cell, e12819

Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button

  • Woodling, N. S.
  • Partridge, L.
(2018) Neuron, 98, 6, 1059-1061

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

  • Catterson, J. H.
  • Khericha, M.
  • Dyson, M. C.
  • Vincent, A. J.
  • Callard, R.
  • Haveron, S. M.
  • Rajasingam, A.
  • Ahmad, M.
  • Partridge, L.
(2018) Curr Biol, 28, 11, 1714-1724 e4

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

  • Augustin, H.
  • McGourty, K.
  • Allen, M. J.
  • Adcott, J.
  • Wong, C. T.
  • Boucrot, E.
  • Partridge, L.
(2018) Neurobiol Aging, 66, 149-157

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

  • Moens, T. G.
  • Mizielinska, S.
  • Niccoli, T.
  • Mitchell, J. S.
  • Thoeng, A.
  • Ridler, C. E.
  • Gronke, S.
  • Esser, J.
  • Heslegrave, A.
  • Zetterberg, H.
  • Partridge, L.
  • Isaacs, A. M.
(2018) Acta Neuropathol, 135, 3, 445-457

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

  • Simone, R.
  • Balendra, R.
  • Moens, T. G.
  • Preza, E.
  • Wilson, K. M.
  • Heslegrave, A.
  • Woodling, N. S.
  • Niccoli, T.
  • Gilbert-Jaramillo, J.
  • Abdelkarim, S.
  • Clayton, E. L.
  • Clarke, M.
  • Konrad, M. T.
  • Nicoll, A. J.
  • Mitchell, J. S.
  • Calvo, A.
  • Chio, A.
  • Houlden, H.
  • Polke, J. M.
  • Ismail, M. A.
  • Stephens, C. E.
  • Vo, T.
  • Farahat, A. A.
  • Wilson, W. D.
  • Boykin, D. W.
  • Zetterberg, H.
  • Partridge, L.
  • Wray, S.
  • Parkinson, G.
  • Neidle, S.
  • Patani, R.
  • Fratta, P.
  • Isaacs, A. M.
(2018) EMBO Mol Med, 10, 1, 22-31

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

  • Bolukbasi, E.
  • Khericha, M.
  • Regan, J. C.
  • Ivanov, D. K.
  • Adcott, J.
  • Dyson, M. C.
  • Nespital, T.
  • Thornton, J. M.
  • Alic, N.
  • Partridge, L.
(2017) Cell Rep, 21, 3, 641-653

Ageing as a risk factor for ALS/FTD

  • Niccoli, T.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Hum Mol Genet, 26, R2, R105-R113

Drosophila as a model for ageing

  • Piper, M. D. W.
  • Partridge, L.
(2017) Biochim Biophys Acta, 1864, 9 Pt A, 2707-2717

A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance

  • Tain, L. S.
  • Sehlke, R.
  • Jain, C.
  • Chokkalingam, M.
  • Nagaraj, N.
  • Essers, P.
  • Rassner, M.
  • Gronke, S.
  • Froelich, J.
  • Dieterich, C.
  • Mann, M.
  • Alic, N.
  • Beyer, A.
  • Partridge, L.
(2017) Mol Syst Biol, 13, 9, 939

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

  • Augustin, H.
  • McGourty, K.
  • Allen, M. J.
  • Madem, S. K.
  • Adcott, J.
  • Kerr, F.
  • Wong, C. T.
  • Vincent, A.
  • Godenschwege, T.
  • Boucrot, E.
  • Partridge, L.
(2017) PLoS Biol, 15, 9, e2001655

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

  • Gorsky, M. K.
  • Burnouf, S.
  • Sofola-Adesakin, O.
  • Dols, J.
  • Augustin, H.
  • Weigelt, C. M.
  • Gronke, S.
  • Partridge, L.
(2017) Sci Rep, 7, 1, 9984

Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan

  • Augustin, H.
  • Adcott, J.
  • Elliott, C. J. H.
  • Partridge, L.
(2017) Fly (Austin), 11, 4, 284-289

Good Ol' Fat: Links between Lipid Signaling and Longevity

  • Bustos, V.
  • Partridge, L.
(2017) Trends Biochem Sci, 42, 10, 812-823

Drug repurposing for aging research using model organisms

  • Ziehm, M.
  • Kaur, S.
  • Ivanov, D. K.
  • Ballester, P. J.
  • Marcus, D.
  • Partridge, L.
  • Thornton, J. M.
(2017) Aging Cell, 16, 5, 1006-1015

Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

  • Brandt, T.
  • Mourier, A.
  • Tain, L. S.
  • Partridge, L.
  • Larsson, N. G.
  • Kuhlbrandt, W.
(2017) Elife, 6

Genetic models of C9orf72: what is toxic?

  • Moens, T. G.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Curr Opin Genet Dev, 44, 92-101

Two forms of death in ageing Caenorhabditis elegans

  • Zhao, Y.
  • Gilliat, A. F.
  • Ziehm, M.
  • Turmaine, M.
  • Wang, H.
  • Ezcurra, M.
  • Yang, C.
  • Phillips, G.
  • McBay, D.
  • Zhang, W. B.
  • Partridge, L.
  • Pincus, Z.
  • Gems, D.
(2017) Nat Commun, 8, 15458

Myostatin-like proteins regulate synaptic function and neuronal morphology

  • Augustin, H.
  • McGourty, K.
  • Steinert, J. R.
  • Cocheme, H. M.
  • Adcott, J.
  • Cabecinha, M.
  • Vincent, A.
  • Halff, E. F.
  • Kittler, J. T.
  • Boucrot, E.
  • Partridge, L.
(2017) Development, 144, 13, 2445-2455

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

  • Mizielinska, S.
  • Ridler, C. E.
  • Balendra, R.
  • Thoeng, A.
  • Woodling, N. S.
  • Grasser, F. A.
  • Plagnol, V.
  • Lashley, T.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Acta Neuropathol Commun, 5, 1, 29

2nd interventions in aging conference

  • Kennedy, B. K.
  • Partridge, L.
(2017) Aging (Albany NY), 9, 4, 1090-1095

2nd interventions in aging conference

  • Kennedy, B. K.
  • Partridge, L.
(2017) Aging (Albany NY), 9, 4, 1090-1095

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

  • Hahn, O.
  • Gronke, S.
  • Stubbs, T. M.
  • Ficz, G.
  • Hendrich, O.
  • Krueger, F.
  • Andrews, S.
  • Zhang, Q.
  • Wakelam, M. J.
  • Beyer, A.
  • Reik, W.
  • Partridge, L.
(2017) Genome Biol, 18, 1, 56

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

  • Piper, M. D.
  • Soultoukis, G. A.
  • Blanc, E.
  • Mesaros, A.
  • Herbert, S. L.
  • Juricic, P.
  • He, X.
  • Atanassov, I.
  • Salmonowicz, H.
  • Yang, M.
  • Simpson, S. J.
  • Ribeiro, C.
  • Partridge, L.
(2017) Cell Metab, 25, 3, 610-621

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease

  • Kerr, F.
  • Sofola-Adesakin, O.
  • Ivanov, D. K.
  • Gatliff, J.
  • Gomez Perez-Nievas, B.
  • Bertrand, H. C.
  • Martinez, P.
  • Callard, R.
  • Snoeren, I.
  • Cocheme, H. M.
  • Adcott, J.
  • Khericha, M.
  • Castillo-Quan, J. I.
  • Wells, G.
  • Noble, W.
  • Thornton, J.
  • Partridge, L.
(2017) PLoS Genet, 13, 3, e1006593

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

  • Kinghorn, K. J.
  • Gronke, S.
  • Castillo-Quan, J. I.
  • Woodling, N. S.
  • Li, L.
  • Sirka, E.
  • Gegg, M.
  • Mills, K.
  • Hardy, J.
  • Bjedov, I.
  • Partridge, L.
(2016) J Neurosci, 36, 46, 11654-11670

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

  • Ding, X.
  • Bloch, W.
  • Iden, S.
  • Ruegg, M. A.
  • Hall, M. N.
  • Leptin, M.
  • Partridge, L.
  • Eming, S. A.
(2016) Nat Commun, 7, 13226

pGluAbeta increases accumulation of Abeta in vivo and exacerbates its toxicity

  • Sofola-Adesakin, O.
  • Khericha, M.
  • Snoeren, I.
  • Tsuda, L.
  • Partridge, L.
(2016) Acta Neuropathol Commun, 4, 1, 109

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

  • Kakanj, P.
  • Moussian, B.
  • Gronke, S.
  • Bustos, V.
  • Eming, S. A.
  • Partridge, L.
  • Leptin, M.
(2016) Nat Commun, 7, 12972

Increased Glucose Transport into Neurons Rescues Abeta Toxicity in Drosophila

  • Niccoli, T.
  • Cabecinha, M.
  • Tillmann, A.
  • Kerr, F.
  • Wong, C. T.
  • Cardenes, D.
  • Vincent, A. J.
  • Bettedi, L.
  • Li, L.
  • Gronke, S.
  • Dols, J.
  • Partridge, L.
(2016) Curr Biol, 26, 17, 2291-300

Small nucleoli are a cellular hallmark of longevity

  • Tiku, V.
  • Jain, C.
  • Raz, Y.
  • Nakamura, S.
  • Heestand, B.
  • Liu, W.
  • Spath, M.
  • Suchiman, H. E. D.
  • Muller, R. U.
  • Slagboom, P. E.
  • Partridge, L.
  • Antebi, A.
(2016) Nat Commun, 8, 16083

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications

  • Kinghorn, K. J.
  • Castillo-Quan, J. I.
  • Li, L.
  • Bhatia, K. P.
  • Abramov, A. Y.
  • Hardy, J.
  • Partridge, L.
(2016) Brain, 139, Pt 12, e68

Dietary Protein, Metabolism, and Aging

  • Soultoukis, G. A.
  • Partridge, L.
(2016) Annu Rev Biochem, 85, 5-34

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

  • Castillo-Quan, J. I.
  • Li, L.
  • Kinghorn, K. J.
  • Ivanov, D. K.
  • Tain, L. S.
  • Slack, C.
  • Kerr, F.
  • Nespital, T.
  • Thornton, J.
  • Hardy, J.
  • Bjedov, I.
  • Partridge, L.
(2016) Cell Rep, 15, 3, 638-50

Deletion of endogenous Tau proteins is not detrimental in Drosophila

  • Burnouf, Sylvie
  • Grönke, Sebastian
  • Augustin, Hrvoje
  • Dols, Jacqueline
  • Gorsky, Marianna Karina
  • Werner, Jennifer
  • Kerr, Fiona
  • Alic, Nazif
  • Martinez, Pedro
  • Partridge, Linda
(2016) Scientific Reports, 6, 23102

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

  • Gorsky, M. K.
  • Burnouf, S.
  • Dols, J.
  • Mandelkow, E.
  • Partridge, L.
(2016) Scientific Reports, 6, 22685

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

  • Regan, Jennifer C.
  • Khericha, Mobina
  • Dobson, Adam J.
  • Bolukbasi, Ekin
  • Rattanavirotkul, Nattaphong
  • Partridge, Linda
(2016) eLife, 5, e10956

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

  • Logan, A.
  • Pell, V R
  • Shaffer, K J
  • Evans, C
  • Stanley, N J
  • Robb, E L
  • Prime, T A
  • Chouchani, E T
  • Cochemé, H M
  • Fearnley, I M
  • Vidoni, S
  • James, A M
  • Porteous, C M
  • Partridge, L
  • Krieg, T
  • Smith, R A J
  • Murphy, M P
(2016) Cell Metabolism, 23, 2, 379-385

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila

  • Afschar, Sonita
  • Toivonen, Janne M.
  • Hoffmann, Julia Marianne
  • Tain, Luke Stephen
  • Wieser, Daniela
  • Finlayson, Andrew John
  • Driege, Yasmine
  • Alic, Nazif
  • Emran, Sahar
  • Stinn, Julia
  • Froehlich, Jenny
  • Piper, Matthew D.
  • Partridge, Linda
(2016) Proceedings of the National Academy of Sciences, 113, 5, 1321-1326

Could cancer drugs provide ammunition against aging?

  • Slack, Cathy
  • Alic, Nazif
  • Partridge, Linda
(2016) Cell Cycle, 15, 2, 153-155

Gerontology: Extending the healthspan

  • Partridge, L.
(2016) Nature, 529, 7585, 154-154

Comments from the departing Editor

  • Partridge, L.
(2016) Philosophical Transactions of the Royal Society of London B: Biological Sciences, 371, 1687, 20150471

Protocols to Study Aging in Drosophila

  • Piper, M. D.
  • Partridge, L.
(2016) Methods Mol Biol, 1478, 291-302

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

  • Iyer, J.
  • Wang, Q.
  • Le, T.
  • Pizzo, L.
  • Gronke, S.
  • Ambegaokar, S. S.
  • Imai, Y.
  • Srivastava, A.
  • Troisi, B. L.
  • Mardon, G.
  • Artero, R.
  • Jackson, G. R.
  • Isaacs, A. M.
  • Partridge, L.
  • Lu, B.
  • Kumar, J. P.
  • Girirajan, S.
(2016) G3 (Bethesda), 6, 5, 1427-37

Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice

  • Essers, P.
  • Tain, L. S.
  • Nespital, T.
  • Goncalves, J.
  • Froehlich, J.
  • Partridge, L.
(2016) Sci Rep, 6, 30290

SurvCurv database and online survival analysis platform update

  • Ziehm, M.
  • Ivanov, D. K.
  • Bhat, A.
  • Partridge, L.
  • Thornton, J. M.
(2015) Bioinformatics, 31, 23, 3878-80

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

  • Knuever, J.
  • Willenborg, S.
  • Ding, X.
  • Akyuz, M. D.
  • Partridge, L.
  • Niessen, C. M.
  • Bruning, J. C.
  • Eming, S. A.
(2015) J Immunol, 195, 11, 5296-308

Longevity GWAS Using the Drosophila Genetic Reference Panel

  • Ivanov, D. K.
  • Escott-Price, V.
  • Ziehm, M.
  • Magwire, M. M.
  • Mackay, T. F.
  • Partridge, L.
  • Thornton, J. M.
(2015) J Gerontol A Biol Sci Med Sci, 70, 12, 1470-8

Translational strategies in aging and age-related disease

  • Armanios, Mary
  • de Cabo, Rafael
  • Mannick, Joan
  • Partridge, Linda
  • van Deursen, Jan
  • Villeda, Saul
(2015) Nat Med, 21, 12, 1395-1399

Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging

  • Hoffmann, J. M.
  • Partridge, L.
(2015) Crit Rev Biochem Mol Biol, 50, 5, 380-92

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

  • Burnouf, Sylvie
  • Gorsky, MariannaKarina
  • Dols, Jacqueline
  • Grönke, Sebastian
  • Partridge, Linda
(2015) Acta Neuropathologica, 130, 1, 35-47

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

  • Menger, Katja E
  • James, Andrew M
  • Cochemé, Helena M
  • Harbour, Michael E.
  • Chouchani, Edward T
  • Ding, Shujing
  • Fearnley, Ian M
  • Partridge, Linda
  • Murphy, Michael P
(2015) Cell Reports, 11, 12, 1856-1865

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

  • Kinghorn, K. J.
  • Castillo-Quan, J. I.
  • Bartolome, F.
  • Angelova, P. R.
  • Li, L.
  • Pope, S.
  • Cocheme, H. M.
  • Khan, S.
  • Asghari, S.
  • Bhatia, K. P.
  • Hardy, J.
  • Abramov, A. Y.
  • Partridge, L.
(2015) Brain, 138, Pt 7, 1801-16

Celebrating 350 years of Philosophical Transactions: life sciences papers

  • Partridge, L.
(2015) Philos Trans R Soc Lond B Biol Sci, 370, 1666

Myc mouse and anti-ageing therapy

  • Alic, N.
  • Partridge, L.
(2015) Trends Endocrinol Metab, 26, 4, 163-4

Promoting Health and Longevity through Diet: From Model Organisms to Humans

  • Fontana, L.
  • Partridge, L.
(2015) Cell, 161, 1, 106-118

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

  • Slack, Cathy
  • Alic, Nazif
  • Foley, Andrea
  • Cabecinha, Melissa
  • Hoddinott, Matthew P
  • Partridge, Linda
(2015) Cell, 162, 1, 72-83

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

  • Bratic, A.
  • Kauppila, T. E.
  • Macao, B.
  • Gronke, S.
  • Siibak, T.
  • Stewart, J. B.
  • Baggio, F.
  • Dols, J.
  • Partridge, L.
  • Falkenberg, M.
  • Wredenberg, A.
  • Larsson, N. G.
(2015) Nat Commun, 6, 8808

Small metazoans

  • Kennedy, B.
  • Kaeberlein, M.
  • Partridge, L.
(2015) Molecular and Cellular Biology of Aging: 84-112

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation

  • Baggio, F.
  • Bratic, A.
  • Mourier, A.
  • Kauppila, T. E.
  • Tain, L. S.
  • Kukat, C.
  • Habermann, B.
  • Partridge, L.
  • Larsson, N. G.
(2014) Nucleic Acids Res, 42, 22, 13920-38

Intervening in ageing to prevent the diseases of ageing

  • Partridge, L.
(2014) Trends Endocrinol Metab, 25, 11, 555-7

Using Doubly-Labeled Water to Measure Energy Expenditure in an Important Small Ectotherm Drosophila melanogaster

  • Piper, Matthew D. W.
  • Selman, Colin
  • Speakman, John R.
  • Partridge, Linda
(2014) Journal of Genetics and Genomics, 41, 9, 505-512

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

  • Alic, N.
  • Giannakou, M. E.
  • Papatheodorou, I.
  • Hoddinott, M. P.
  • Andrews, T. D.
  • Bolukbasi, E.
  • Partridge, L.
(2014) PLoS Genet, 10, 9, e1004619

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

  • Mizielinska, S.
  • Grönke, S.
  • Niccoli, T.
  • Ridler, C. E.
  • Clayton, E. L.
  • Devoy, A.
  • Moens, T.
  • Norona, F. E.
  • Woollacott, I. O. C.
  • Pietrzyk, J.
  • Cleverley, K.
  • Nicoll, A. J.
  • Pickering-Brown, S.
  • Dols, J.
  • Cabecinha, M.
  • Hendrich, O.
  • Fratta, P.
  • Fisher, E. M. C.
  • Partridge, L.
  • Isaacs, A. M.
(2014) Science, 345, 6201, 1192-1194

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

  • Mauer, J.
  • Chaurasia, B.
  • Goldau, J.
  • Vogt, M. C.
  • Ruud, J.
  • Nguyen, K. D.
  • Theurich, S.
  • Hausen, A. C.
  • Schmitz, J.
  • Bronneke, H. S.
  • Estevez, E.
  • Allen, T. L.
  • Mesaros, A.
  • Partridge, L.
  • Febbraio, M. A.
  • Chawla, A.
  • Wunderlich, F. T.
  • Bruning, J. C.
(2014) Nat Immunol, 15, 5, 423-30

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila

  • Metaxakis, A.
  • Tain, L. S.
  • Gronke, S.
  • Hendrich, O.
  • Hinze, Y.
  • Birras, U.
  • Partridge, L.
(2014) PLoS Biol, 12, 4, e1001824

Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

  • Alic, N.
  • Tullet, J. M.
  • Niccoli, T.
  • Broughton, S.
  • Hoddinott, M. P.
  • Slack, C.
  • Gems, D.
  • Partridge, L.
(2014) Cell Rep, 6, 4, 608-16

Editorial 2014

  • Partridge, L.
(2014) Philos Trans R Soc Lond B Biol Sci, 369, 1633, 20130496

A holidic medium for Drosophila melanogaster

  • Piper, M. D.
  • Blanc, E.
  • Leitao-Goncalves, R.
  • Yang, M.
  • He, X.
  • Linford, N. J.
  • Hoddinott, M. P.
  • Hopfen, C.
  • Soultoukis, G. A.
  • Niemeyer, C.
  • Kerr, F.
  • Pletcher, S. D.
  • Ribeiro, C.
  • Partridge, L.
(2014) Nat Methods, 11, 1, 100-5

Lithium suppresses Abeta pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

  • Sofola-Adesakin, O.
  • Castillo-Quan, J. I.
  • Rallis, C.
  • Tain, L. S.
  • Bjedov, I.
  • Rogers, I.
  • Li, L.
  • Martinez, P.
  • Khericha, M.
  • Cabecinha, M.
  • Bahler, J.
  • Partridge, L.
(2014) Front Aging Neurosci, 6, 190

MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals

  • Wredenberg, A.
  • Lagouge, M.
  • Bratic, A.
  • Metodiev, M. D.
  • Spahr, H.
  • Mourier, A.
  • Freyer, C.
  • Ruzzenente, B.
  • Tain, L.
  • Gronke, S.
  • Baggio, F.
  • Kukat, C.
  • Kremmer, E.
  • Wibom, R.
  • Polosa, P. L.
  • Habermann, B.
  • Partridge, L.
  • Park, C. B.
  • Larsson, N. G.
(2013) PLoS Genet, 9, 1, e1003178

Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster

  • Metaxakis, A.
  • Partridge, L.
(2013) PLoS ONE, 8, 9, e74681

Gender and longevity: why do men die earlier than women? Comparative and experimental evidence

  • Regan, J. C.
  • Partridge, L.
(2013) Best Pract Res Clin Endocrinol Metab, 27, 4, 467-79

The hallmarks of aging

  • Lopez-Otin, C.
  • Blasco, M. A.
  • Partridge, L.
  • Serrano, M.
  • Kroemer, G.
(2013) Cell, 153, 6, 1194-217

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

  • Chouchani, E. T.
  • Methner, C.
  • Nadtochiy, S. M.
  • Logan, A.
  • Pell, V. R.
  • Ding, S.
  • James, A. M.
  • Cocheme, H. M.
  • Reinhold, J.
  • Lilley, K. S.
  • Partridge, L.
  • Fearnley, I. M.
  • Robinson, A. J.
  • Hartley, R. C.
  • Smith, R. A.
  • Krieg, T.
  • Brookes, P. S.
  • Murphy, M. P.
(2013) Nat Med, 19, 6, 753-9

Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster

  • Lee, S. F.
  • Eyre-Walker, Y. C.
  • Rane, R. V.
  • Reuter, C.
  • Vinti, G.
  • Rako, L.
  • Partridge, L.
  • Hoffmann, A. A.
(2013) Mol Ecol, 22, 10, 2716-25

Genes, pathways and metabolism in ageing

  • Slack, Cathy
  • Partridge, Linda
(2013) Drug Discovery Today: Disease Models, 10, 2, e87-e93

Genetics of longevity in model organisms: debates and paradigm shifts

  • Gems, D.
  • Partridge, L.
(2013) Annu Rev Physiol, 75, 621-44

Diet and healthy aging

  • Partridge, L.
(2012) N Engl J Med, 367, 26, 2550-1

Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing

  • Papatheodorou, I.
  • Ziehm, M.
  • Wieser, D.
  • Alic, N.
  • Partridge, L.
  • Thornton, J. M.
(2012) PLoS ONE, 7, 12, e50881

Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females

  • Gioti, A.
  • Wigby, S.
  • Wertheim, B.
  • Schuster, E.
  • Martinez, P.
  • Pennington, C. J.
  • Partridge, L.
  • Chapman, T.
(2012) Proc Biol Sci, 279, 1746, 4423-32

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

  • Slack, C.
  • Foley, A.
  • Partridge, L.
(2012) PLoS ONE, 7, 10, e47699

Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies

  • Alic, N.
  • Hoddinott, M. P.
  • Foley, A.
  • Slack, C.
  • Piper, M. D.
  • Partridge, L.
(2012) PLoS ONE, 7, 9, e45367

Ageing as a risk factor for disease

  • Niccoli, T.
  • Partridge, L.
(2012) Curr Biol, 22, 17, R741-52

Experimental analysis of risk factors for ulcerative dermatitis in mice

  • Neuhaus, B.
  • Niessen, C. M.
  • Mesaros, A.
  • Withers, D. J.
  • Krieg, T.
  • Partridge, L.
(2012) Exp Dermatol, 21, 9, 712-3

Ageing Increases Vulnerability to Aβ42 Toxicity in

  • Rogers, Iain
  • Kerr, Fiona
  • Martinez, Pedro
  • Hardy, John
  • Lovestone, Simon
  • Partridge, Linda
(2012) PLoS ONE, 7, 7, e40569

The place of genetics in ageing research

  • Barzilai, Nir
  • Guarente, Leonard
  • Kirkwood, Thomas B. L.
  • Partridge, Linda
  • Rando, Thomas A.
  • Slagboom, P. Eline
(2012) Nat Rev Genet, 13, 8, 589-594

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

  • Aghdam, S. Y.
  • Eming, S. A.
  • Willenborg, S.
  • Neuhaus, B.
  • Niessen, C. M.
  • Partridge, L.
  • Krieg, T.
  • Bruning, J. C.
(2012) Biochem Biophys Res Commun, 421, 2, 197-202

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

  • Cocheme, H. M.
  • Logan, A.
  • Prime, T. A.
  • Abakumova, I.
  • Quin, C.
  • McQuaker, S. J.
  • Patel, J. V.
  • Fearnley, I. M.
  • James, A. M.
  • Porteous, C. M.
  • Smith, R. A.
  • Hartley, R. C.
  • Partridge, L.
  • Murphy, M. P.
(2012) Nat Protoc, 7, 5, 946-58

Genome-Wide Transcription Analysis of Clinal Genetic Variation in

  • Chen, Ying
  • Lee, Siu F.
  • Blanc, Eric
  • Reuter, Caroline
  • Wertheim, Bregje
  • Martinez-Diaz, Pedro
  • Hoffmann, Ary A.
  • Partridge, Linda
(2012) PLoS ONE, 7, 4, e34620

Current developments at Philosophical Transactions of the Royal Society B

  • Partridge, L.
(2012) Philos Trans R Soc Lond B Biol Sci, 367, 1585, 3

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice

  • Selman, C.
  • Partridge, L.
(2012) Cell Cycle, 11, 1, 17-8

Death and dessert: nutrient signalling pathways and ageing

  • Alic, N.
  • Partridge, L.
(2011) Curr Opin Cell Biol, 23, 6, 738-43

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in

  • Bratic, A.
  • Wredenberg, A.
  • Grönke, S.
  • Stewart, J. B.
  • Mourier, A.
  • Ruzzenente, B.
  • Kukat, C.
  • Wibom, R.
  • Habermann, B.
  • Partridge, L.
  • Larsson, N. G.
(2011) PLoS Genet, 7, 10, e1002324

dFOXO-independent effects of reduced insulin-like signaling in Drosophila

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  • Partridge, L.
(2011) Aging Cell, 10, 5, 735-48

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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  • Piper, M. D.
  • Hoddinott, M.
  • Sutphin, G. L.
  • Leko, V.
  • McElwee, J. J.
  • Vazquez-Manrique, R. P.
  • Orfila, A. M.
  • Ackerman, D.
  • Au, C.
  • Vinti, G.
  • Riesen, M.
  • Howard, K.
  • Neri, C.
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(2011) Nature, 477, 7365, 482-5

Dietary restriction and aging: a unifying perspective

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  • Partridge, L.
  • Raubenheimer, D.
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(2011) Cell Metab, 14, 2, 154-60

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

  • Alic, N.
  • Andrews, T. D.
  • Giannakou, M. E.
  • Papatheodorou, I.
  • Slack, C.
  • Hoddinott, M. P.
  • Cocheme, H. M.
  • Schuster, E. F.
  • Thornton, J. M.
  • Partridge, L.
(2011) Mol Syst Biol, 7, 502

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

  • Partridge, L.
  • Alic, N.
  • Bjedov, I.
  • Piper, M. D.
(2011) Exp Gerontol, 46, 5, 376-81

Unraveling the biological roles of reactive oxygen species

  • Murphy, M. P.
  • Holmgren, A.
  • Larsson, N. G.
  • Halliwell, B.
  • Chang, C. J.
  • Kalyanaraman, B.
  • Rhee, S. G.
  • Thornalley, P. J.
  • Partridge, L.
  • Gems, D.
  • Nystrom, T.
  • Belousov, V.
  • Schumacker, P. T.
  • Winterbourn, C. C.
(2011) Cell Metab, 13, 4, 361-6

A longer and healthier life with TOR down-regulation: genetics and drugs

  • Bjedov, I.
  • Partridge, L.
(2011) Biochem Soc Trans, 39, 2, 460-5

Molecular basis of adaptive shift in body size in

  • Lee, S. F.
  • Chen, Y.
  • Varan, A. K.
  • Wee, C. W.
  • Rako, L.
  • Axford, J. K.
  • Good, R. T.
  • Blacket, M. J.
  • Reuter, C.
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(2011) Mol Biol Evol, 28, 8, 2393-402

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

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  • Quin, C.
  • McQuaker, S. J.
  • Cabreiro, F.
  • Logan, A.
  • Prime, T. A.
  • Abakumova, I.
  • Patel, J. V.
  • Fearnley, I. M.
  • James, A. M.
  • Porteous, C. M.
  • Smith, R. A.
  • Saeed, S.
  • Carre, J. E.
  • Singer, M.
  • Gems, D.
  • Hartley, R. C.
  • Partridge, L.
  • Murphy, M. P.
(2011) Cell Metab, 13, 3, 340-50

Electrophysiological recordings from the giant fiber pathway of

  • Augustin, H.
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  • Partridge, L.
(2011) J Vis Exp, 47

Insulin signalling regulates remating in female Drosophila

  • Wigby, S.
  • Slack, C.
  • Grönke, S.
  • Martinez, P.
  • Calboli, F. C.
  • Chapman, T.
  • Partridge, L.
(2011) Proc Biol Sci, 278, 1704, 424-31

Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1

  • Selman, C.
  • Partridge, L.
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(2011) PLoS One, 6, 1, e16144

Some highlights of research on aging with invertebrates, 2010

  • Partridge, L.
(2011) Aging Cell, 10, 1, 5-9

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

  • Alic, N.
  • Hoddinott, M. P.
  • Vinti, G.
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(2011) Aging Cell, 10, 1, 137-47

The new science of ageing

  • Partridge, L.
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(2011) Philos Trans R Soc Lond B Biol Sci, 366, 1561, 6-8

Comments from the new Editor

  • Partridge, Linda
(2011) Philosophical Transactions of the Royal Society B: Biological Sciences, 366, 1561, 5

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

  • Kerr, F.
  • Augustin, H.
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  • Gandy, C.
  • Allen, M. J.
  • Lovestone, S.
  • Partridge, L.
(2011) Neurobiol Aging, 32, 11, 1977-89

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

  • Sofola, O.
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  • Allen, M. J.
  • Hardy, J.
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(2010) PLoS Genet, 6, 9, e1001087

Dietary Restriction: Standing Up for Sirtuins Response

  • Fontana, L.
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(2010) Science, 329(5995): 1013-1013

Dietary Restriction: Theory Fails to Satiate - Response

  • Fontana, L., Partridge, L., Longo, V.D.
(2010) Science, 329(5995): 1015

Biomarkers of aging in Drosophila

  • Jacobson, J.
  • Lambert, A. J.
  • Portero-Otin, M.
  • Pamplona, R.
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  • Miwa, S.
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(2010) Aging Cell, 9, 4, 466-77

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

  • Broughton, S. J.
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  • Alic, N.
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  • Bass, T. M.
  • Driege, Y.
  • Partridge, L.
(2010) Aging Cell, 9, 3, 336-46

Extending healthy life span--from yeast to humans

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(2010) Science, 328, 5976, 321-6

Water-independent effects of dietary restriction in Drosophila

  • Piper, M. D.
  • Wong, R.
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  • Partridge, L.
(2010) Proc Natl Acad Sci U S A, 107, 14, E54-6; author reply E57

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk

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  • Alic, N.
  • Foley, A.
  • Stocker, H.
  • Withers, D. J.
  • Thornton, J. M.
  • Hafen, E.
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(2010) PLoS Genet, 6, 3, e1000881

Molecular evolution and functional characterization of Drosophila insulin-like peptides

  • Grönke, S.
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  • Partridge, L.
(2010) PLoS Genet, 6, 2, e1000857

The new biology of ageing

  • Partridge, L.
(2010) Philos Trans R Soc Lond B Biol Sci, 365, 1537, 147-54

Mechanisms of life span extension by rapamycin in the fruit fly

  • Bjedov, I.
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  • Kerr, F.
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(2010) Cell Metab, 11, 1, 35-46

The functions of Insulin-like peptides in insects

  • Grönke, S.
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(2010) Research and Perspectives in Endocrine Interactions — IGFs: Local Repair and Survival Factors Throughout Life Span, 105-124

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

  • Grandison, R. C.
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(2009) Nature, 462, 7276, 1061-4

A Drosophila insulin-like peptide promotes growth during nonfeeding states

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(2009) Dev Cell, 17, 6, 874-84

Chemical changes in aging

  • Iqbal, A.
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(2009) Age (Dordr), 31, 4, 343-51

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

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(2009) Proc Biol Sci, 276, 1674, 3799-807

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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(2009) Science, 326, 5949, 140-4

Invertebrate models of age-related muscle degeneration

  • Augustin, H.
  • Partridge, L.
(2009) Biochim Biophys Acta, 1790, 10, 1084-94

Some highlights of research on aging with invertebrates, 2009

  • Partridge, L.
(2009) Aging Cell, 8, 5, 509-13

Quantification of food intake in Drosophila

  • Wong, R.
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(2009) PLoS One, 4, 6, e6063

Longevity of Indy mutant Drosophila not attributable to Indy mutation

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(2009) Proc Natl Acad Sci U S A, 106, 21, E53; author reply E54

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

  • Humphrey, D. M.
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  • Partridge, L.
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(2009) Exp Gerontol, 44, 5, 316-27

Insulin/IGF-like signalling, the central nervous system and aging

  • Broughton, S.
  • Partridge, L.
(2009) Biochem J, 418, 1, 1-12

Endocrine regulation of aging and reproduction in Drosophila

  • Toivonen, J. M.
  • Partridge, L.
(2009) Mol Cell Endocrinol, 299, 1, 39-50

Effect of a standardised dietary restriction protocol on multiple laboratory strains of

  • Grandison, R. C.
  • Wong, R.
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  • Partridge, L.
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(2009) PLoS One, 4, 1, e4067

Ageing flies

  • Partridge, L.
(2009) Journal of Neurogenetics, 23, S1-S1

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs

  • Broughton, S.
  • Alic, N.
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  • Bass, T.
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  • Vinti, G.
  • Tommasi, A. M.
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  • Partridge, L.
(2008) PLoS One, 3, 11, e3721

Some highlights of research on aging with invertebrates, 2008

  • Partridge, L.
(2008) Aging Cell, 7, 5, 605-8

Feeding, fecundity and lifespan in female

  • Barnes, A. I.
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  • Partridge, L.
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(2008) Proc Biol Sci, 275, 1643, 1675-83

Stage debut for the elusive Drosophila insulin-like growth factor binding protein

  • Alic, N.
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(2008) J Biol, 7, 6, 18

Toward a control theory analysis of aging

  • Murphy, M. P.
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(2008) Annu Rev Biochem, 77, 777-98

New model of health promotion and disease prevention for the 21st century

  • Butler, R. N.
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  • Brody, J.
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  • Partridge, L.
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(2008) BMJ, 337, a399

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

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(2008) Science, 320, 5879, 1012; author reply 1012

Forkhead transcription factors and ageing

  • Partridge, L.
  • Brüning, J. C.
(2008) Oncogene, 27, 16, 2351-63

Pitfalls of measuring feeding rate in the fruit fly

  • Wong, R.
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  • Partridge, L.
(2008) Nat Methods, 5, 3, 214-5; author reply 215

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

  • Selman, C.
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  • Piper, M. D.
  • Al-Qassab, H.
  • Speakman, J. R.
  • Carmignac, D.
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  • Thornton, J. M.
  • Gems, D.
  • Partridge, L.
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(2008) FASEB J, 22, 3, 807-18

Role of dFOXO in lifespan extension by dietary restriction in

  • Giannakou, M. E.
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  • Partridge, L.
(2008) Aging Cell, 7, 2, 187-98

Stress-response hormesis and aging: "that which does not kill us makes us stronger"

  • Gems, D.
  • Partridge, L.
(2008) Cell Metab, 7, 3, 200-3

Molecular biology of aging

  • Guarente, Leonard P.
  • Partiridge, Linda
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(2008) Cold Spring Harbor monograph series, 51, VIII, 610 S.

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

  • Piper, M. D.
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  • Partridge, L.
(2008) J Intern Med, 263, 2, 179-91

Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in

  • Milton, C. C.
  • Partridge, L.
(2008) J Insect Physiol, 54, 1, 32-40

Chemical complexity and the genetics of aging

  • Pletcher, S. D.
  • Kabil, H.
  • Partridge, L.
(2007) Annual Review of Ecology Evolution and Systematics, 38, 299-326

Benchmarks for ageing studies

  • Partridge, L.
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(2007) Nature, 450, 7167, 165-7

Some highlights of research on aging with invertebrates, 2006-2007

  • Partridge, L.
(2007) Aging Cell, 6, 5, 595-8

Effects of resveratrol on lifespan in

  • Bass, T. M.
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  • Gems, D.
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(2007) Mech Ageing Dev, 128, 10, 546-52

Optimization of dietary restriction protocols in Drosophila

  • Bass, T. M.
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(2007) J Gerontol A Biol Sci Med Sci, 62, 10, 1071-81

Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster

  • Kennington, W. J.
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  • Partridge, L.
(2007) Genetics, 177, 1, 549-56

Antagonizing Methuselah to extend life span

  • Alic, N.
  • Partridge, L.
(2007) Genome Biol, 8, 8, 222

Dynamics of the action of dFOXO on adult mortality in Drosophila

  • Giannakou, M. E.
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  • Partridge, L.
(2007) Aging Cell, 6, 4, 429-38

Evolutionary conservation of regulated longevity assurance mechanisms

  • McElwee, J. J.
  • Schuster, E.
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  • Thomas, J. H.
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  • Partridge, L.
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(2007) Genome Biol, 8, 7, R132

Correcting for sequence biases in present/absent calls

  • Schuster, E. F.
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(2007) Genome Biol, 8, 6, R125

Estimation and correction of non-specific binding in a large-scale spike-in experiment

  • Schuster, E. F.
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(2007) Genome Biol, 8, 6, R126

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

  • Toivonen, J. M.
  • Walker, G. A.
  • Martinez-Diaz, P.
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(2007) PLoS Genet, 3, 6, e95

Aging of the genome: The dual role of DNA in life and death

  • Partridge, L.
(2007) Nature, 447, 7142, 262-263

Dietary restriction in Drosophila: delayed aging or experimental artefact?

  • Piper, M. D.
  • Partridge, L.
(2007) PLoS Genet, 3, 4, e57

Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1016/j.exger.2006.10.009

  • Piper, M.
  • Mair, W.
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(2007) Exp Gerontol, 42, 4, 253-5

Insulin signalling, oxidative stress and aging

  • Partridge, Linda
(2007) Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 146, 4, Supplement, S59-S60

Superoxide dismutase activities in long-lived

  • Kabil, H.
  • Partridge, L.
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(2007) Biogerontology, 8, 2, 201-8

Role of insulin-like signalling in Drosophila lifespan

  • Giannakou, M. E.
  • Partridge, L.
(2007) Trends Biochem Sci, 32, 4, 180-8

A functioning ovary is not required for sex peptide to reduce receptivity to mating in

  • Barnes, A. I.
  • Boone, J. M.
  • Partridge, L.
  • Chapman, T.
(2007) J Insect Physiol, 53, 4, 343-8

Functional genomics of plastic and evolutionary responses to thermal stress

  • Wertheim, B.
  • Milton, C.
  • Hoffmann, A.
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  • Partridge, L.
(2007) Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology, 146, 4, Supplement, S206

Of worms, mice & men: altering rates of aging

  • Partridge, L.
(2006) Daedalus, 135, 1, 40-47

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice

  • Selman, C.
  • Kerrison, N. D.
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  • Piper, M. D.
  • Lingard, S. J.
  • Barton, R. H.
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  • Partridge, L.
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(2006) Physiol Genomics, 27, 3, 187-200

Beyond the evolutionary theory of ageing, from functional genomics to evo-gero

  • Partridge, L.
  • Gems, D.
(2006) Trends Ecol Evol, 21, 6, 334-40

Debating sexual selection and mating strategies

  • Pizzari, T.
  • Birkhead, T. R.
  • Blows, M. W.
  • Brooks, R.
  • Buchanan, K. L.
  • Clutton-Brock, T. H.
  • Harvey, P. H.
  • Hosken, D. J.
  • Jennions, M. D.
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  • Kotiaho, J. S.
  • Lessells, C. M.
  • Macias-Garcia, C.
  • Moore, A. J.
  • Parker, G. A.
  • Partigridge, L.
  • Pitnick, S.
  • Radwan, J.
  • Ritchie, M.
  • Sheldon, B. C.
  • Simmons, L. W.
  • Snook, R. R.
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(2006) Science, 312, 5774, 690; author reply 689-97

No extension of lifespan by ablation of germ line in Drosophila

  • Barnes, A. I.
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  • Jacobson, J.
  • Partridge, L.
  • Chapman, T.
(2006) Proc Biol Sci, 273, 1589, 939-47

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in

  • Magwere, T.
  • West, M.
  • Riyahi, K.
  • Murphy, M. P.
  • Smith, R. A.
  • Partridge, L.
(2006) Mech Ageing Dev, 127, 4, 356-70

Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in

  • Kennington, W. J.
  • Partridge, L.
  • Hoffmann, A. A.
(2006) Genetics, 172, 3, 1655-63

Flight activity, mortality rates, and lipoxidative damage in Drosophila

  • Magwere, T.
  • Pamplona, R.
  • Miwa, S.
  • Martinez-Diaz, P.
  • Portero-Otin, M.
  • Brand, M. D.
  • Partridge, L.
(2006) J Gerontol A Biol Sci Med Sci, 61, 2, 136-45

The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila

  • Magwere, T.
  • Goodall, S.
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  • Mair, W.
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  • Partridge, L.
(2006) J Gerontol A Biol Sci Med Sci, 61, 1, 36-47

Models of insulin signalling and longevity

  • Piper, Matthew D. W.
  • Selman, Colin
  • McElwee, Joshua J.
  • Partridge, Linda
(2005) Drug Discovery Today: Disease Models, 2, 4, 249-256

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

  • Warner, H.
  • Anderson, J.
  • Austad, S.
  • Bergamini, E.
  • Bredesen, D.
  • Butler, R.
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  • Clark, B. F.
  • Cristofalo, V.
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  • Guarente, L.
  • Harrison, D. E.
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  • Lithgow, G.
  • Martin, G.
  • Masoro, E.
  • Melov, S.
  • Miller, R. A.
  • Olshansky, S. J.
  • Partridge, L.
  • Pereira-Smith, O.
  • Perls, T.
  • Richardson, A.
  • Smith, J.
  • von Zglinicki, T.
  • Wang, E.
  • Wei, J. Y.
  • Williams, T. F.
(2005) EMBO Rep, 6, 11, 1006-8

Diet, metabolism and lifespan in Drosophila

  • Piper, M. D.
  • Skorupa, D.
  • Partridge, L.
(2005) Exp Gerontol, 40, 11, 857-62

Genome-wide gene expression in response to parasitoid attack in Drosophila

  • Wertheim, B.
  • Kraaijeveld, A. R.
  • Schuster, E.
  • Blanc, E.
  • Hopkins, M.
  • Pletcher, S. D.
  • Strand, M. R.
  • Partridge, L.
  • Godfray, H. C.
(2005) Genome Biol, 6, 11, R94

Dietary restriction in Drosophila

  • Partridge, L.
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(2005) Mech Ageing Dev, 126, 9, 938-50

Special issue on dietary restriction: Dietary restriction, longevity and ageing-the current state of our knowledge and ignorance

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(2005) Mechanisms of Ageing and Development, 126, 9, 911-912

Calories do not explain extension of life span by dietary restriction in Drosophila

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(2005) PLoS Biol, 3, 7, e223

Counting the calories: the role of specific nutrients in extension of life span by food restriction

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(2005) J Gerontol A Biol Sci Med Sci, 60, 5, 549-55

Insulin signaling is necessary for vitellogenesis in

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(2005) J Insect Physiol, 51, 4, 455-64

Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in

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(2005) J Neurogenet, 19, 2, 57-85

Genetic variation for total fitness in

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(2005) Genetics, 169, 3, 1553-71

Sex and death: what is the connection?

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(2005) Cell, 120, 4, 461-72

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

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(2005) Proc Natl Acad Sci U S A, 102, 8, 3105-10

Response to comment on "Long-lived Drosophila with overexpressed dFOXO in adult fat body"

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(2005) Science, 307, 5710

Dietary restriction, mortality trajectories, risk and damage

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(2005) Mech Ageing Dev, 126, 1, 35-41

The interaction between FOXO and SIRT1: tipping the balance towards survival

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(2004) Trends Cell Biol, 14, 8, 408-12

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in

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(2004) Exp Gerontol, 39, 8, 1137-43

Computational analysis of alpha-helical membrane protein structure: implications for the prediction of 3D structural models

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(2004) Protein Eng Des Sel, 17, 8, 613-24

Long-lived Drosophila with overexpressed dFOXO in adult fat body

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(2004) Science, 305, 5682, 361

Lifespan extension by dietary restriction in female

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(2004) Exp Gerontol, 39, 7, 1011-9

Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila

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(2004) Ann N Y Acad Sci, 1019, 388-91

Dietary restriction in Drosophila - Response

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(2004) Science, 303, 5664, 1611-1612

Sex differences in the effect of dietary restriction on life span and mortality rates in female and male

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(2004) J Gerontol A Biol Sci Med Sci, 59, 1, 3-9

QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of

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(2003) Evolution, 57, 11, 2653-8

Testing for asymmetrical gene flow in a

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(2003) Genetics, 165, 2, 667-73

Superoxide and hydrogen peroxide production by Drosophila mitochondria

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(2003) Free Radic Biol Med, 35, 8, 938-48

Demography of dietary restriction and death in Drosophila

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(2003) Science, 301, 5640, 1731-3

The sex peptide of

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(2003) Proc Natl Acad Sci U S A, 100, 17, 9923-8

Costing reproduction

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(2003) Animal Behaviour, 66, 2, 199-204

Overwintering in Drosophila melanogaster: outdoor field cage experiments on clinal and laboratory selected populations help to elucidate traits under selection

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(2003) J Evol Biol, 16, 4, 614-23

Rapid laboratory evolution of adult wing area in

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(2003) Evolution, 57, 4, 932-6

Influence of female reproductive anatomy on the outcome of sperm competition in

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(2003) Proc Biol Sci, 270, 1514, 523-30

Different cell size and cell number contribution in two newly established and one ancient body size cline of

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(2003) Evolution, 57, 3, 566-73

Ageless quest: One scientist's search for genes that prolong youth

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(2003) Nature, 421, 6925, 789-790

Genetics of ageing in Drosophila

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(2003) Biology of Aging and Its Modulation—Aging of Organisms, 4, 125-161

A genetic perspective of Drosophila melanogaster latitudinal body size clines

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(2003) Genes in the environment, 15, 63-75

Life history response of Mediterranean fruit flies to dietary restriction

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(2002) Aging Cell, 1, 2, 140-8

Interpreting interactions between treatments that slow aging

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(2002) Aging Cell, 1, 1, 1-9

A lethal side-effect

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(2002) Nature, 418, 6901, 921

The evolution of longevity

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(2002) Curr Biol, 12, 16, R544-6

Quantitative genetic analysis of natural variation in body size in

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(2002) Heredity (Edinb), 89, 2, 145-53

Dietary Restriction and Life-Span

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(2002) Science, 296, 5576, 2141-2142

Food pulses increase longevity and induce cyclical egg production in Mediterranean fruit flies

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(2002) Functional Ecology, 16, 3, 313-325

Genome-wide transcript profiles in aging and calorically restricted

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(2002) Curr Biol, 12, 9, 712-23

Dietary restriction in long-lived dwarf flies

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(2002) Science, 296, 5566, 319

A mortality cost of virginity at older ages in female Mediterranean fruit flies

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(2002) Exp Gerontol, 37, 4, 507-12

Mechanisms of ageing: public or private?

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(2002) Nat Rev Genet, 3, 3, 165-75

Identifying common determinants of lifespan and ageing in model organisms

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(2002) Mechanisms of Ageing and Development, 123, 4, 441-442

Temperature modulates epidermal cell size in

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(2002) J Insect Physiol, 48, 2, 231-237

Effects of body size, accessory gland and testis size on pre- and postcopulatory success in

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(2002) Animal Behaviour, 64, 6, 915-921

Laboratory adaptation of life history in Drosophila

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(2001) Am Nat, 158, 6, 657-8

The genetic bases of divergence in desiccation and starvation resistance among tropical and temperate populations of

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(2001) Heredity (Edinb), 87, Pt 3, 363-72

The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in

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(2001) Proc Biol Sci, 268, 1477, 1647-54

Genetic variation for preadult viability in

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(2001) Evolution, 55, 8, 1609-20

Insulin/IGF signalling and ageing: seeing the bigger picture

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(2001) Curr Opin Genet Dev, 11, 3, 287-92

Nonclinality of molecular variation implicates selection in maintaining a morphological cline of

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(2001) Genetics, 158, 1, 319-23

Evolutionary theories of ageing applied to long-lived organisms

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(2001) Exp Gerontol, 36, 4-6, 641-50

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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(2001) Science, 292, 5514, 104-6

Effects of assay conditions in life history experiments with

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(2001) J Evol Biol, 14, 2, 199-209

Female sensitivity to diet and irradiation treatments underlies sex-mortality differentials in the Mediterranean fruit fly

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(2001) J Gerontol A Biol Sci Med Sci, 56, 2, B89-93

Rapid loss of stress resistance in

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(2001) Evolution, 55, 2, 436-8

The contrasting genetic architecture of wing size and shape in

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(2001) Heredity (Edinb), 86, Pt 2, 144-52

Temperature and clinal variation in larval growth efficiency in

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(2001) J Evol Biol, 14, 1, 14-21

The genetics of aging in Drosophila

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(2001) The handbooks of aging, 345-360

Genetics and Ecology

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(2001) Ecology : Achievement and Challenge, 41, 3-23

Selection on age at reproduction in

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(2000) Evolution, 54, 6, 2152-5

Limits to natural selection

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(2000) Bioessays, 22, 12, 1075-84

Evolutionary Responses of the Life History of Wild‐Caught

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(2000) The American Naturalist, 156, 4, 341-353

Starvation resistance and adult body composition in a latitudinal cline of

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(2000) Evolution, 54, 5, 1819-24

Increased body size confers greater fitness at lower experimental temperature in male

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(2000) J Evol Biol, 13, 5, 836-844

Evolving evolvability

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(2000) Nature, 407, 6803, 457-8

The Identification of Endothelial Cell Autoantigens

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(2000) Journal of Autoimmunity, 15, 1, 41-49

The role of male accessory gland protein Acp36DE in sperm competition in

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(2000) Proc Biol Sci, 267, 1448, 1097-105

Measuring fitness by means of balancer chromosomes

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(2000) Genet Res, 75, 3, 297-313

Why it is difficult to model sperm displacement in

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(2000) Evolution, 54, 2, 534-42

Cellular basis of wing size variation in

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(2000) Heredity (Edinb), 84 ( Pt 3), 338-47

Adaptation and constraint in the evolution of

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(2000) Evol Dev, 2, 2, 114-24

A delayed wave of death from reproduction in Drosophila

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(1999) Science, 286, 5449, 2521-4

A comparison of the genetic basis of wing size divergence in three parallel body size clines of

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(1999) Genetics, 153, 4, 1775-87

Messages from mortality: the evolution of death rates in the old

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(1999) Trends Ecol Evol, 14, 11, 438-442

Mating-induced inhibition of remating in female Mediterranean fruit flies

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(1999) J Insect Physiol, 45, 11, 1021-1028

Correlated responses to selection on body size in

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(1999) Genet Res, 74, 1, 43-54

Another set of responses and correlated responses to selection on age at reproduction in

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(1999) Proc Biol Sci, 266, 1416, 255-61

Sexual conflict and speciation.

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(1999) Evolution of biological diversity: 130-159

The evolution of non-infectious and degenreative disease.

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(1999) Evolution in health and disease: 267-272

Evolution, senescence and health in old age.

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(1999) Evolution in health and disease: 219-230

Sex-specific selection on time to remate in

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(1998) Anim Behav, 56, 5, 1267-1278

Body size and cell size in Drosophila: the developmental response to temperature

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(1998) J Insect Physiol, 44, 11, 1081-1089

Interactions of mating, egg production and death rates in females of the Mediterranean fruit fly,

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(1998) Proc Biol Sci, 265, 1408, 1879-94

Latitudinal variation of wing : thorax size ratio and wing-aspect ratio in

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(1998) Evolution, 52, 5, 1353-1362

Sex and conflict

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(1998) Science, 281, 5385, 2003-8

Pervasive effects of P element mutagenesis on body size in

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(1998) Genet Res, 72, 1, 19-24

Geographic variation in competitive ability in

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(1998) Am Nat, 151, 6, 530-7

Regulation of gene expression is preserved in aging

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(1998) Curr Biol, 8, 8, 475-8

Evolutionary ecology - Different routes to similar ends

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(1998) Nature, 392, 6676, 552-553

Sexual conflict and speciation

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(1998) Philos Trans R Soc Lond B Biol Sci, 353, 1366, 261-74

Behavioural genetics: molecular genetics meets feeding ecology

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(1998) Curr Biol, 8, 1, R23-4

Why we age: what science is discovering about the body's journey through life

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(1997) Nat Med, 3(12): 1410-1411

Influence of temperature and activity on the metabolic rate of adult

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(1997) Comp Biochem Physiol A Physiol, 118, 4, 1301-7

Mating and hormonal triggers regulate accessory gland gene expression in male Drosophila

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(1997) J Insect Physiol, 43, 12, 1117-1123

Heritability of pre-adult viability differences can explain apparent heritability of sperm displacement ability in

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(1997) Proc Biol Sci, 264, 1386, 1271-5

An interaction between environmental temperature and genetic variation for body size for the fitness of adult female

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(1997) Evolution, 51, 4, 1164-1174

Life-history consequences of egg size in

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(1997) Am Nat, 150, 2, 250-82

Ageing: levelling of the grim reaper

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(1997) Curr Biol, 7, 7, R440-2

Genetic and environmental responses to temperature of

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(1997) Genetics, 146, 3, 881-90

Thermal sensitivity of

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(1997) Physiol Zool, 70, 4, 403-14

The effects of reproduction on longevity and fertility in male

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(1997) J Insect Physiol, 43, 6, 501-512

Bergmann's rule in ectotherms: Is it adaptive?

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(1997) Evolution, 51, 2, 632-635

Genetic variation for total fitness in

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(1997) Proc Biol Sci, 264, 1379, 191-9

Joint regulation of cell size and cell number in the wing blade of

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(1997) Genet Res, 69, 1, 61-8

Evolutionary biology and age-related mortality

  • Partridge, Linda
(1997) Between Zeus and the salmon : the biodemography of longevity, 78-95

Thermal evolution of egg size in

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(1996) Evolution, 50, 6, 2338-2345

Lack of response to sex-peptide results in increased cost of mating in dunce

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(1996) J Insect Physiol, 42, 11-12, 1007-1015

On measuring the rate of ageing

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(1996) Proceedings of the Royal Society B-Biological Sciences, 263, 1375, 1365-1371

Evolutionary responses of

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(1996) J Evol Biol, 9, 5, 609-622

Courtship reduces longevity of male

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(1996) Animal Behaviour, 52, 269-278

Female fitness in

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(1996) Proc Biol Sci, 263, 1371, 755-9

Sexual conflict as fuel for evolution

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(1996) Nature, 381, 6579, 189-90

Thermal evolution of extotherm body size: why get big in the cold?

  • Partridge, Linda
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(1996) Animals and temperature: phenotypic and evolutionary adaptation, 59, 265-292

Message from a non-pest species

  • Partridge, Linda
(1996) Fruit fly pests : a world assessment of their biology and management - Proceedings of the IV International Symposium on Fruit Flies of Economic Importance

Male Identity and Sperm Displacement in

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(1995) J Insect Physiol, 41, 12, 1087-1092

Rapid Laboratory Evolution of Adult Life-History Traits in

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(1995) Evolution, 49, 3, 538-544

Cellular basis and developmental timing in a size cline of

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(1995) Genetics, 140, 2, 659-66

Thermal Evolution of Rate of Larval Development in

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(1995) J Evol Biol, 8, 3, 315-330

Thermal evolution of growth efficiency in

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(1995) Proc Biol Sci, 260, 1357, 73-8

Cost of mating in

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(1995) Nature, 373, 6511, 241-4

Population biology. A crash course in survival

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(1994) Nature, 372, 6504, 318-9

Thermal Evolution of Pre-Adult Life-History Traits in

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(1994) J Evol Biol, 7, 6, 645-663

Evolution and Development of Body-Size and Cell-Size in

  • Partridge, L.
  • Barrie, B.
  • Fowler, K.
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(1994) Evolution, 48, 4, 1269-1276

Gerontology. Mutation, variation and the evolution of ageing

  • Partridge, L.
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(1994) Curr Biol, 4, 5, 430-2

Gene-environment interaction for body size and larval density in

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  • Partridge, L.
(1994) Heredity (Edinb), 72 ( Pt 5), 515-21

Remating and male-derived nutrients in

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(1994) J Evol Biol, 7, 1, 51-69

Genetic and nongenetic approaches to questions about sexual selection

  • Partridge, Linda
(1994) Quantitative genetic studies of behavioral evolution: 126-141

Gerontology. Methuselah among nematodes

  • Partridge, L.
  • Harvey, P. H.
(1993) Nature, 366, 6454, 404-5

No reduction in the cost of mating for

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(1993) Proc Biol Sci, 253, 1338, 211-7

Evolutionary biology. Menopause for thought

  • Partridge, L.
(1993) Nature, 364, 6436, 386

Optimality, mutation and the evolution of ageing

  • Partridge, L.
  • Barton, N. H.
(1993) Nature, 362, 6418, 305-11

Evolutionary Effects of Selection on Age at Reproduction in Larval and Adult

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(1993) Evolution, 47, 2, 445-455

Responses and Correlated Responses to Artificial Selection on Thorax Length in

  • Partridge, L.
  • Fowler, K.
(1993) Evolution, 47, 1, 213-226

Evolution of aging: testing the theory using Drosophila

  • Partridge, L.
  • Barton, N. H.
(1993) Genetica, 91, 1-3, 89-98

Haldane's rule and the hazards of heterogamety

  • Partridge, L.
(1993) Curr Biol, 3, 1, 56-8

Genetic correlation between the sexes in

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  • Partridge, L.
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(1993) Animal Behaviour, 45, 2, 405

Direct and Correlated Responses to Selection on Age at Reproduction in

  • Partridge, L.
  • Fowler, K.
(1992) Evolution, 46, 1, 76-91

Evolutionary biology. What the sperm count costs

  • Partridge, L.
  • Harvey, P. H.
(1992) Nature, 360, 6403, 415

On the use of tester stocks to predict the competitive ability of genotypes

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  • Fowler, K.
  • Partridge, L.
(1992) Heredity (Edinb), 69 ( Pt 6), 489-95

A genetic correlation between the sexes for mating speed in

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  • Partridge, Linda
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(1992) Animal Behaviour, 43, 3, 389-396

Measuring reproductive costs

  • Partridge, L.
(1992) Trends Ecol Evol, 7, 3, 99-100

These hierarchical views of life: Phylogenies and metapopulations.

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  • Partridge, Linda
(1992) Genes in Ecology: 123-137

A paradox for biology

  • Partridge, L.
(1991) Science, 252, 5008, 1000-1

Thermal Sensitivity of

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  • Partridge, L.
  • Fowler, K.
(1991) Evolution, 45, 3, 751-756

A cost of receiving sperm in the female fruitfly

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  • Partridge, Linda
(1991) J Insect Physiol, 37, 6, 471-475

Constraints in the Evolution of Life Histories [and Discussion]

  • Partridge, Linda
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(1991) Philos Trans R Soc Lond B Biol Sci, 332(1262): 3-13

Clutch Size

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  • Partridge, Linda
  • Harvey, P. H.
(1991) Annu Rev Ecol, 22: 409-429

Variation in mating behaviour and reproductive success of male Drosophila.

  • Partridge, Linda
(1991) Proceedings of the International Symposium on Biology and Control of Fruit Flies Held in Ginowan, Okinawa, Japan

The evolution of reproductive strategies : proceedings of a Royal Society Discussion Meeting held on 17 and 18 October 1990

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  • Partridge, L.
  • Southwood, Richard Sir
  • Royal, Society
(1991) Philosophical transactions of the Royal Society of London. v.332, no.1262 Series B ;: vi, 104 p

Resistance of Genetic Correlation Structure to Directional Selection in

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  • Partridge, L.
(1990) Evolution, 44, 8, 1990-2003

Non-mating costs of exposure to males in female

  • Partridge, Linda
  • Fowler, Kevin
(1990) J Insect Physiol, 36, 6, 419-425

Frequency-dependent mating preferences in female fruitflies?

  • Partridge, L.
(1989) Behav Genet, 19, 5, 725-8

A Cost of Mating in Female Fruit-Flies

  • Fowler, K.
  • Partridge, L.
(1989) Nature, 338, 6218, 760-761

Ageing and lifespan

  • Partridge, Linda
(1989) Lifetime reproduction in birds, 421-440

An experimentalist's approach to the analysis of life history and evolution

  • Partridge, Linda
(1989) Toward a more exact ecology: 231-246

Oxford surveys in evolutionary biology

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  • Partridge, Linda
(1989) , 6: 248 p.

Territorial Interrogative

  • Partridge, L.
(1988) Trends in Ecology & Evolution, 3, 12, 317-318

Is Bacterial Evolution Random or Selective

  • Partridge, L.
  • Morgan, M. J.
(1988) Nature, 336, 6194, 22-22

Evolutionary Biology - of Cuckoo Clocks and Cowbirds

  • Harvey, P. H.
  • Partridge, L.
(1988) Nature, 335, 6191, 586-587

The ecological context of life history evolution

  • Partridge, L.
  • Harvey, P. H.
(1988) Science, 241, 4872, 1449-55

An effect of egg-deposition on the subsequent fertility and remating frequency of female

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  • Partridge, Linda
(1988) J Insect Physiol, 34, 8, 821-828

A courtship advantage for small males in Drosophila subobscura

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  • Partridge, Linda
(1988) Animal Behaviour, 36, 4, 1190-1197

The rare-male effect: what is its evolutionary significance?

  • Partridge, L.
(1988) Philos Trans R Soc Lond B Biol Sci, 319, 1196, 525-39

Lifetime reproductive success in Drosophila

  • Partridge, Linda
(1988) Reproductive success : studies of individual variation in contrasting breeding systems: 11-23

Oxford surveys in evolutionary biology

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(1988) , 5: 272 p.

Frequency-dependent selection : Proceedings of a Royal Society Discussion Meeting held on 24 and 25 June 1987

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  • Partridge, Linda
(1988) Philosophical transactions of the Royal Society of London. v.319, no.1196, pp 457-640 Series B, Biological sciences ;: v, 182 p.

Transfer of molecules from ejaculate to females in Drosophila melanogaster and

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  • Partridge, Linda
(1987) J Insect Physiol, 33, 12, 941-947

Effects of egg-production and of exposure to males on female survival in

  • Partridge, Linda
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(1987) J Insect Physiol, 33, 10, 745-749

An advantage for specialist feeding in jackdaws,

  • Partridge, Linda
  • Green, Paul
(1987) Animal Behaviour, 35, 4, 982-990

A Case of Mistaken Identity in Swordtail Fish

  • Partridge, L.
  • Harvey, P. H.
(1987) Nature, 328, 6129, 377-377

Estimation of the Thermal Niche of

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  • Partridge, Linda
(1987) The American Naturalist, 130, 1, 83-90

Male size and mating success in Drosophila melanogaster and D. pseudoobscura under field conditions

  • Partridge, Linda
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(1987) Animal Behaviour, 35, 2, 468-476

Male size and mating success in

  • Partridge, Linda
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(1987) Animal Behaviour, 35, 2, 555-562

Murderous Mandibles and Black-Holes in Hymenopteran Wasps

  • Harvey, P. H.
  • Partridge, L.
(1987) Nature, 326, 6109, 128-129

Is Accelerated Senescence a Cost of Reproduction?

  • Partridge, L.
(1987) Functional Ecology, 1, 4, 317-320

Constraints on the effects of sexual selection

  • Partridge, Linda
  • Price, T. D.
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(1987) Sexual Selection: Testing the alternatives : Report(39): 278-294

Life History Constraints on Sexual Selection

  • Partridge, Linda
(1987) Sexual Selection: Testing the alternatives : Report(39): 265-277

Oxford surveys in evolutionary biology

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  • Partridge, Linda
(1987) , 4: 248p

An examination of the effects of males on the survival and egg-production rates of female

  • Partridge, Linda
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(1986) J Insect Physiol, 32, 11, 925-929

Contentious Issues in Sexual Selection

  • Partridge, L.
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(1986) Nature, 323, 6089, 580-581

Variation in Male-Fertility Explains an Apparent Effect of Genotypic Diversity on Success in Larval Competition in

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  • Partridge, L.
(1986) Heredity, 57, 31-36

Genetics of Mate Choice

  • Partridge, L.
(1986) Trends in Genetics, 2, 1, 1-1

Sexual activity and lifespan

  • Partridge, Linda
(1986) Insect aging : strategies and mechanism: 44-54

Male Mating Success and Fertility in

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(1985) Genetical Research, 46, 3, 279-285

Evolutionary Biology - Costs of Reproduction

  • Partridge, L.
  • Harvey, P. H.
(1985) Nature, 316, 6023, 20-20

The effect of reproductive activity on the longevity of male

  • Partridge, Linda
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(1985) J Insect Physiol, 31, 5, 393-395

Evolutionary Biology - Group Selection and the Sex-Ratio

  • Harvey, P. H.
  • Partridge, L.
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(1985) Nature, 313, 5997, 10-11

Individual feeding specialisations and population dynamics

  • Partridge, Linda
  • Green, P.
(1985) Behavioural ecology : ecolog. consequences of adaptive behaviour ; Reading, 1984(25): 207-226

When deviants are favoured: evolution of sex determination

  • Harvey, P. H.
  • Partridge, L.
(1984) Nature, 307, 5953, 689-91

Mechanisms for Frequency-Dependent Mating Success

  • Partridge, L.
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(1984) Biological Journal of the Linnean Society, 23, 2-3, 113-132

Mating patterns and mate choice

  • Partridge, Linda
  • Halliday, T. R.
(1984) Behavioural ecology : an evolutionary approach: 222-250

Failure to Replicate the Results of an Experiment on the Rare Male Effect in

  • Partridge, L.
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(1983) American Naturalist, 122, 3, 422-427

Tissue rejection: the price of sexual acceptance?

  • Jones, J. S.
  • Partridge, L.
(1983) Nature, 304, 5926, 484-5

Lifetime mating success of male fruitflies (

  • Partridge, Linda
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(1983) Animal Behaviour, 31, 3, 871-877

Non-random mating and offspring fitness

  • Partridge, Linda
(1983) Mate choice, 227-256

Genetics and behaviour

  • Partridge, Linda
(1983) Animal behaviour. Vol. 3: Genes, Development and Learning, 3(v 3): 11-51

Bird Coloration and Parasites - a Task for the Future

  • Harvey, P. H.
  • Partridge, L.
(1982) Nature, 300, 5892, 480-481

Sexual-Activity Reduces Lifespan of Male Fruitflies

  • Partridge, L.
  • Farquhar, M.
(1981) Nature, 294, 5841, 580-582

Olfactory Preferences of Inbred Mice (

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  • Partridge, L.
(1981) Behaviour, 78, 314-324

Effects of nutrition and peripheral stimuli on preferences for familiar foods in the bank vole

  • Partridge, Linda
  • Maclean, Rona
(1981) Animal Behaviour, 29, 1, 217-220

Increased preferences for familiar foods in small mammals

  • Partridge, Linda
(1981) Animal Behaviour, 29, 1, 211-216

Mate Choice Increases a Component of Offspring Fitness in Fruit Flies

  • Partridge, L.
(1980) Nature, 283, 5744, 290-291

Differences in behaviour between blue and coal tits reared under identical conditions

  • Partridge, Linda
(1979) Animal Behaviour, 27, Part 1, 120-125

The evolution and Genetics of behaviour

  • Partridge, Linda
(1979) Brain, Behaviour and Evolution: 1-27

Habitat selection

  • Partridge, Linda
(1978) Behavioural ecology : an evolutionary approach: 351-376

Canary Island Blue Tits and English Coal Tits - Convergent Evolution

  • Partridge, L.
  • Pringmill, F.
(1977) Evolution, 31, 3, 657-665

Three-generation family conflict

  • Partridge, Linda
  • Nunney, Len
(1977) Animal Behaviour, 25, Part 3, 785-786

Field and laboratory observations on the foraging and feeding techniques of blue tits (

  • Partridge, Linda
(1976) Animal Behaviour, 24, 3, 534-544

Some Aspects of Morphology of Blue Tits (

  • Partridge, L.
(1976) Journal of Zoology, 179, May, 121-133

Individual differences in feeding efficiencies and feeding preferences of captive great tits

  • Partridge, Linda
(1976) Animal Behaviour, 24, 1, 230-240

Mixed-Species Flocks of Birds in Hill Forest in Ceylon

  • Partridge, L.
  • Ashcroft, R.
(1976) Condor, 78, 4, 449-453

Habitat Selection in Titmice

  • Partridg.L
(1974) Nature, 247, 5442, 573-574

Behavioural aspects of the ecology of some paridae

  • Partridge, Linda
(1974) : v, 210 leaves : ill. ; 31 cm.

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