Abteilung Partridge (im Abbau)

Publikationen

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

  • Kuan, V.
  • Denaxas, S.
  • Patalay, P.
  • Nitsch, D.
  • Mathur, R.
  • Gonzalez-Izquierdo, A.
  • Sofat, R.
  • Partridge, L.
  • Roberts, A.
  • Wong, I. C. K.
  • Hingorani, M.
  • Chaturvedi, N.
  • Hemingway, H.
  • Hingorani, A. D.
  • Multimorbidity, Mechanism
  • Therapeutic Research, Collaborative
(2023) Lancet Digit Health, 5, 1, e16-e27

Hallmarks of aging: An expanding universe

  • Lopez-Otin, C.
  • Blasco, M. A.
  • Partridge, L.
  • Serrano, M.
  • Kroemer, G.
(2022) Cell

Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity

  • Romano, N.
  • Di Giacomo, B.
  • Nobile, V.
  • Borreca, A.
  • Willems, D.
  • Tilesi, F.
  • Catalani, E.
  • Agrawal, M.
  • Welshhans, K.
  • Ricciardi, S.
  • Cervia, D.
  • Ceci, M.
(2022) Int J Mol Sci, 23, 19

Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

  • Segref, A.
  • Vakkayil, K. L.
  • Padvitski, T.
  • Li, Q.
  • Kroef, V.
  • Lormann, J.
  • Korner, L.
  • Finger, F.
  • Hoppe, T.
(2022) Nat Commun, 13, 1, 5874

Molecular inhibition of RAS signalling to target ageing and age-related health

  • Laskovs, M.
  • Partridge, L.
  • Slack, C.
(2022) Dis Model Mech, 15, 10

The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila

  • Srivastava, A.
  • Lu, J.
  • Gadalla, D. S.
  • Hendrich, O.
  • Gronke, S.
  • Partridge, L.
(2022) Front Aging, 3, 944466

Biological mechanisms of aging predict age-related disease co-occurrence in patients

  • Fraser, Helen C.
  • Kuan, Valerie
  • Johnen, Ronja
  • Zwierzyna, Magdalena
  • Hingorani, Aroon D.
  • Beyer, Andreas
  • Partridge, Linda
(2022) Aging Cell, 21, 4, e13524

Meeting Report: Aging Research and Drug Discovery

  • Meron, E.
  • Thaysen, M.
  • Angeli, S.
  • Antebi, A.
  • Barzilai, N.
  • Baur, J. A.
  • Bekker-Jensen, S.
  • Birkisdottir, M.
  • Bischof, E.
  • Bruening, J.
  • Brunet, A.
  • Buchwalter, A.
  • Cabreiro, F.
  • Cai, S.
  • Chen, B. H.
  • Ermolaeva, M.
  • Ewald, C. Y.
  • Ferrucci, L.
  • Florian, M. C.
  • Fortney, K.
  • Freund, A.
  • Georgievskaya, A.
  • Gladyshev, V. N.
  • Glass, D.
  • Golato, T.
  • Gorbunova, V.
  • Hoejimakers, J.
  • Houtkooper, R. H.
  • Jager, S.
  • Jaksch, F.
  • Janssens, G.
  • Jensen, M. B.
  • Kaeberlein, M.
  • Karsenty, G.
  • de Keizer, P.
  • Kennedy, B.
  • Kirkland, J. L.
  • Kjaer, M.
  • Kroemer, G.
  • Lee, K. F.
  • Lemaitre, J. M.
  • Liaskos, D.
  • Longo, V. D.
  • Lu, Y. X.
  • MacArthur, M. R.
  • Maier, A. B.
  • Manakanatas, C.
  • Mitchell, S. J.
  • Moskalev, A.
  • Niedernhofer, L.
  • Ozerov, I.
  • Partridge, L.
  • Passegue, E.
  • Petr, M. A.
  • Peyer, J.
  • Radenkovic, D.
  • Rando, T. A.
  • Rattan, S.
  • Riedel, C. G.
  • Rudolph, L.
  • Ai, R.
  • Serrano, M.
  • Schumacher, B.
  • Sinclair, D. A.
  • Smith, R.
  • Suh, Y.
  • Taub, P.
  • Trapp, A.
  • Trendelenburg, A. U.
  • Valenzano, D. R.
  • Verburgh, K.
  • Verdin, E.
  • Vijg, J.
  • Westendorp, R. G. J.
  • Zonari, A.
  • Bakula, D.
  • Zhavoronkov, A.
  • Scheibye-Knudsen, M.
(2022) Aging (Albany NY), 14, 2, 530-543

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

  • Baghdadi, M.
  • Hinterding, H. M
  • Partridge, L.
  • Deelen, J.
(2022) Briefings in Functional Genomics, 1, 25, 13-23

Lithium can mildly increase health during ageing but not lifespan in mice

  • Nespital, T.
  • Neuhaus, B.
  • Mesaros, A.
  • Pahl, A.
  • Partridge, L.
(2021) Aging Cell, 10, 20, e13479

A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation

  • Li, L.
  • Conradson, D. M.
  • Bharat, V.
  • Kim, M. J.
  • Hsieh, C. H.
  • Minhas, P. S.
  • Papakyrikos, A. M.
  • Durairaj, A. S.
  • Ludlam, A.
  • Andreasson, K. I.
  • Partridge, L.
  • Cianfrocco, M. A.
  • Wang, X.
(2021) Nat Metab, 9, 3, 1242-1258

Functional conservation in genes and pathways linking ageing and immunity

  • Fabian, D. K.
  • Fuentealba, M.
  • Donertas, H. M.
  • Partridge, L.
  • Thornton, J. M.
(2021) Immun Ageing, 18, 1, 23

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

  • Lu, Y. X.
  • Regan, J. C.
  • Esser, J.
  • Drews, L. F.
  • Weinseis, T.
  • Stinn, J.
  • Hahn, O.
  • Miller, R. A.
  • Gronke, S.
  • Partridge, L.
(2021) Elife, 10

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity

  • Niccoli, T.
  • Kerr, F.
  • Snoeren, I.
  • Fabian, D.
  • Aleyakpo, B.
  • Ivanov, D.
  • Sofola-Adesakin, O.
  • Cryar, A.
  • Adcott, J.
  • Thornton, J.
  • Partridge, L.
(2021) Brain Commun, 3, 2, fcab053

Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults

  • Dzankic, P. J.
  • Partridge, L.
(2021) Lancet Healthy Longev, 2, 5, e232-e233

Common genetic associations between age-related diseases

  • Donertas, H. M.
  • Fabian, D. K.
  • Valenzuela, M. F.
  • Partridge, L.
  • Thornton, J. M.
(2021) Nat Aging, 1, 4, 400-412

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

  • Tain, L. S.
  • Sehlke, R.
  • Meilenbrock, R. L.
  • Leech, T.
  • Paulitz, J.
  • Chokkalingam, M.
  • Nagaraj, N.
  • Gronke, S.
  • Frohlich, J.
  • Atanassov, I.
  • Mann, M.
  • Beyer, A.
  • Partridge, L.
(2021) Elife, 10

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

  • Atilano, M. L.
  • Gronke, S.
  • Niccoli, T.
  • Kempthorne, L.
  • Hahn, O.
  • Moron-Oset, J.
  • Hendrich, O.
  • Dyson, M.
  • Adams, M. L.
  • Hull, A.
  • Salcher-Konrad, M. T.
  • Monaghan, A.
  • Bictash, M.
  • Glaria, I.
  • Isaacs, A. M.
  • Partridge, L.
(2021) Elife, 10

FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity

  • Kapetanou, M.
  • Nespital, T.
  • Tain, L. S.
  • Pahl, A.
  • Partridge, L.
  • Gonos, E. S.
(2021) Front Cell Dev Biol, 9, 625715

Transposable element landscape in Drosophila populations selected for longevity

  • Fabian, D. K.
  • Melike Donertas, H.
  • Fuentealba, M.
  • Partridge, L.
  • Thornton, J. M.
(2021) Genome Biol Evol, 13, 4, evab031

Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system

  • Bolukbasi, E.
  • Woodling, N. S.
  • Ivanov, D. K.
  • Adcott, J.
  • Foley, A.
  • Rajasingam, A.
  • Gittings, L. M.
  • Aleyakpo, B.
  • Niccoli, T.
  • Thornton, J. M.
  • Partridge, L.
(2021) Proc Natl Acad Sci U S A, 118, 8

A neuronal blood marker is associated with mortality in old age

  • Kaeser, S. A.
  • Lehallier, B.
  • Thinggaard, M.
  • Häsler, L.M.
  • Apel, A.
  • Bergmann, C.
  • Berdnik, D.
  • Jeune, B.
  • Christensen, K.
  • Grönke, S.
  • Partridge, L.
  • Wyss-Coray, T.
  • Mengel-From, J.
  • Jucker, M.
(2021) Nature Aging, 1, 2, 218-225

Data-driven identification of ageing-related diseases from electronic health records

  • Kuan, V.
  • Fraser, H. C.
  • Hingorani, M.
  • Denaxas, S.
  • Gonzalez-Izquierdo, A.
  • Direk, K.
  • Nitsch, D.
  • Mathur, R.
  • Parisinos, C. A.
  • Lumbers, R. T.
  • Sofat, R.
  • Wong, I. C. K.
  • Casas, J. P.
  • Thornton, J. M.
  • Hemingway, H.
  • Partridge, L.
  • Hingorani, A. D.
(2021) Sci Rep, 11, 1, 2938

Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults

  • Cox, L. S.
  • Bellantuono, I.
  • Lord, J. M.
  • Sapey, E.
  • Mannick, J. B.
  • Partridge, L.
  • Gordon, A. L.
  • Steves, C. J.
  • Witham, M. D.
(2021) Lancet Healthy Longev, 1, 2, e55-e57

Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids

  • Lu, J.
  • Temp, U.
  • Müller-Hartmann, A.
  • Esser, J.
  • Grönke, S.
  • Partridge, L.
(2021) Nature Aging, 1, 1, 60-72

Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

  • Fuentealba, M.
  • Fabian, D. K.
  • Donertas, H. M.
  • Thornton, J. M.
  • Partridge, L.
(2021) Mech Ageing Dev, 194, 111437

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

  • Bjedov, I.
  • Cocheme, H. M.
  • Foley, A.
  • Wieser, D.
  • Woodling, N. S.
  • Castillo-Quan, J. I.
  • Norvaisas, P.
  • Lujan, C.
  • Regan, J. C.
  • Toivonen, J. M.
  • Murphy, M. P.
  • Thornton, J.
  • Kinghorn, K. J.
  • Neufeld, T. P.
  • Cabreiro, F.
  • Partridge, L.
(2020) PLoS Genet, 16, 11, e1009083

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

  • Woodling, N. S.
  • Rajasingam, A.
  • Minkley, L. J.
  • Rizzo, A.
  • Partridge, L.
(2020) BMC Biol, 18, 1, 124

The quest to slow ageing through drug discovery

  • Partridge, L.
  • Fuentealba, M.
  • Kennedy, B. K.
(2020) Nat Rev Drug Discov, 19, 8, 513-532

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

  • Weigelt, C. M.
  • Sehgal, R.
  • Tain, L. S.
  • Cheng, J.
  • Esser, J.
  • Pahl, A.
  • Dieterich, C.
  • Gronke, S.
  • Partridge, L.
(2020) Mol Cell, 79, 2, 268-279 e5

PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity

  • Yu, Y.
  • Niccoli, T.
  • Ren, Z.
  • Woodling, N. S.
  • Aleyakpo, B.
  • Szabadkai, G.
  • Partridge, L.
(2020) Hum Mol Genet, 29, 14, 2420-2434

The neuronal receptor tyrosine kinase Alk is a target for longevity

  • Woodling, N. S.
  • Aleyakpo, B.
  • Dyson, M. C.
  • Minkley, L. J.
  • Rajasingam, A.
  • Dobson, A. J.
  • Leung, K. H. C.
  • Pomposova, S.
  • Fuentealba, M.
  • Alic, N.
  • Partridge, L.
(2020) Aging Cell, 19, 5, e13137

Long-term in vivo imaging of Drosophila larvae

  • Kakanj, P.
  • Eming, S. A.
  • Partridge, L.
  • Leptin, M.
(2020) Nat Protoc, 15, 3, 1158-1187

Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production

  • Tain, L. S.
  • Jain, C.
  • Nespital, T.
  • Froehlich, J.
  • Hinze, Y.
  • Gronke, S.
  • Partridge, L.
(2020) Aging Cell, 19, 1, e13043

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

  • Moron-Oset, J.
  • Super, T.
  • Esser, J.
  • Isaacs, A. M.
  • Gronke, S.
  • Partridge, L.
(2019) Acta Neuropathol Commun, 7, 1, 209

A nutritional memory effect counteracts benefits of dietary restriction in old mice

  • Hahn, O.
  • Drews, L. F.
  • Nguyen, A.
  • Tatsuta, T.
  • Gkioni, L.
  • Hendrich, O.
  • Zhang, Q.
  • Langer, T.
  • Pletcher, S.
  • Wakelam, M. J. O.
  • Beyer, A.
  • Gronke, S.
  • Partridge, L.
(2019) Nat Metab, 1, 11, 1059-1073

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

  • Castillo-Quan, J. I.
  • Tain, L. S.
  • Kinghorn, K. J.
  • Li, L.
  • Gronke, S.
  • Hinze, Y.
  • Blackwell, T. K.
  • Bjedov, I.
  • Partridge, L.
(2019) Proc Natl Acad Sci U S A, 116, 42, 20817-20819

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

  • Yamada, S. B.
  • Gendron, T. F.
  • Niccoli, T.
  • Genuth, N. R.
  • Grosely, R.
  • Shi, Y.
  • Glaria, I.
  • Kramer, N. J.
  • Nakayama, L.
  • Fang, S.
  • Dinger, T. J. I.
  • Thoeng, A.
  • Rocha, G.
  • Barna, M.
  • Puglisi, J. D.
  • Partridge, L.
  • Ichida, J. K.
  • Isaacs, A. M.
  • Petrucelli, L.
  • Gitler, A. D.
(2019) Nat Neurosci, 22, 9, 1383-1388

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

  • Solon-Biet, S. M.
  • Cogger, V. C.
  • Pulpitel, T.
  • Wahl, D.
  • Clark, X.
  • Bagley, E.
  • Gregoriou, G. C.
  • Senior, A. M.
  • Wang, Q. P.
  • Brandon, A. E.
  • Perks, R.
  • O'Sullivan, J.
  • Koay, Y. C.
  • Bell-Anderson, K.
  • Kebede, M.
  • Yau, B.
  • Atkinson, C.
  • Svineng, G.
  • Dodgson, T.
  • Wali, J. A.
  • Piper, M. D. W.
  • Juricic, P.
  • Partridge, L.
  • Rose, A. J.
  • Raubenheimer, D.
  • Cooney, G. J.
  • Le Couteur, D. G.
  • Simpson, S. J.
(2019) Nat Metab, 1, 5, 532-545

A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster

  • Augustin, H.
  • Zylbertal, A.
  • Partridge, L.
(2019) eNeuro, 6, 2

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A

  • Moens, T. G.
  • Niccoli, T.
  • Wilson, K. M.
  • Atilano, M. L.
  • Birsa, N.
  • Gittings, L. M.
  • Holbling, B. V.
  • Dyson, M. C.
  • Thoeng, A.
  • Neeves, J.
  • Glaria, I.
  • Yu, L.
  • Bussmann, J.
  • Storkebaum, E.
  • Pardo, M.
  • Choudhary, J. S.
  • Fratta, P.
  • Partridge, L.
  • Isaacs, A. M.
(2019) Acta Neuropathol, 137, 3, 487-500

Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster

  • Weigelt, C. M.
  • Hahn, O.
  • Arlt, K.
  • Gruhn, M.
  • Jahn, A. J.
  • Esser, J.
  • Werner, J. A.
  • Klein, C.
  • Buschges, A.
  • Gronke, S.
  • Partridge, L.
(2019) Life Sci Alliance, 2, 1

Identifying Potential Ageing-Modulating Drugs In Silico

  • Donertas, H. M.
  • Fuentealba, M.
  • Partridge, L.
  • Thornton, J. M.
(2019) Trends Endocrinol Metab, 30, 2, 118-131

Using the drug-protein interactome to identify anti-ageing compounds for humans

  • Fuentealba, M.
  • Donertas, H. M.
  • Williams, R.
  • Labbadia, J.
  • Thornton, J. M.
  • Partridge, L.
(2019) PLoS Comput Biol, 15, 1, e1006639

Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila

  • Juricic, P.
  • Gronke, S.
  • Partridge, L.
(2019) J Gerontol A Biol Sci Med Sci, 75, 1, 24-31

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity

  • Hahn, O.
  • Stubbs, T. M.
  • Reik, W.
  • Gronke, S.
  • Beyer, A.
  • Partridge, L.
(2018) PLoS Genet, 14, 11, e1007766

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

  • Kauppila, T. E. S.
  • Bratic, A.
  • Jensen, M. B.
  • Baggio, F.
  • Partridge, L.
  • Jasper, H.
  • Gronke, S.
  • Larsson, N. G.
(2018) Proc Natl Acad Sci U S A, 115, 41, E9620-E9629

Facing up to the global challenges of ageing

  • Partridge, L.
  • Deelen, J.
  • Slagboom, P. E.
(2018) Nature, 561, 7721, 45-56

Horizons in the evolution of aging

  • Flatt, T.
  • Partridge, L.
(2018) BMC Biol, 16, 1, 93

Gene Expression-Based Drug Repurposing to Target Ageing

  • Donertas, H. M.
  • Fuentealba Valenzuela, M.
  • Partridge, L.
  • Thornton, J. M.
(2018) Aging Cell, e12819

Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button

  • Woodling, N. S.
  • Partridge, L.
(2018) Neuron, 98, 6, 1059-1061

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

  • Catterson, J. H.
  • Khericha, M.
  • Dyson, M. C.
  • Vincent, A. J.
  • Callard, R.
  • Haveron, S. M.
  • Rajasingam, A.
  • Ahmad, M.
  • Partridge, L.
(2018) Curr Biol, 28, 11, 1714-1724 e4

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

  • Augustin, H.
  • McGourty, K.
  • Allen, M. J.
  • Adcott, J.
  • Wong, C. T.
  • Boucrot, E.
  • Partridge, L.
(2018) Neurobiol Aging, 66, 149-157

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

  • Moens, T. G.
  • Mizielinska, S.
  • Niccoli, T.
  • Mitchell, J. S.
  • Thoeng, A.
  • Ridler, C. E.
  • Gronke, S.
  • Esser, J.
  • Heslegrave, A.
  • Zetterberg, H.
  • Partridge, L.
  • Isaacs, A. M.
(2018) Acta Neuropathol, 135, 3, 445-457

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

  • Simone, R.
  • Balendra, R.
  • Moens, T. G.
  • Preza, E.
  • Wilson, K. M.
  • Heslegrave, A.
  • Woodling, N. S.
  • Niccoli, T.
  • Gilbert-Jaramillo, J.
  • Abdelkarim, S.
  • Clayton, E. L.
  • Clarke, M.
  • Konrad, M. T.
  • Nicoll, A. J.
  • Mitchell, J. S.
  • Calvo, A.
  • Chio, A.
  • Houlden, H.
  • Polke, J. M.
  • Ismail, M. A.
  • Stephens, C. E.
  • Vo, T.
  • Farahat, A. A.
  • Wilson, W. D.
  • Boykin, D. W.
  • Zetterberg, H.
  • Partridge, L.
  • Wray, S.
  • Parkinson, G.
  • Neidle, S.
  • Patani, R.
  • Fratta, P.
  • Isaacs, A. M.
(2018) EMBO Mol Med, 10, 1, 22-31

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

  • Bolukbasi, E.
  • Khericha, M.
  • Regan, J. C.
  • Ivanov, D. K.
  • Adcott, J.
  • Dyson, M. C.
  • Nespital, T.
  • Thornton, J. M.
  • Alic, N.
  • Partridge, L.
(2017) Cell Rep, 21, 3, 641-653

Ageing as a risk factor for ALS/FTD

  • Niccoli, T.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Hum Mol Genet, 26, R2, R105-R113

Drosophila as a model for ageing

  • Piper, M. D. W.
  • Partridge, L.
(2017) Biochim Biophys Acta, 1864, 9 Pt A, 2707-2717

A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance

  • Tain, L. S.
  • Sehlke, R.
  • Jain, C.
  • Chokkalingam, M.
  • Nagaraj, N.
  • Essers, P.
  • Rassner, M.
  • Gronke, S.
  • Froelich, J.
  • Dieterich, C.
  • Mann, M.
  • Alic, N.
  • Beyer, A.
  • Partridge, L.
(2017) Mol Syst Biol, 13, 9, 939

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

  • Augustin, H.
  • McGourty, K.
  • Allen, M. J.
  • Madem, S. K.
  • Adcott, J.
  • Kerr, F.
  • Wong, C. T.
  • Vincent, A.
  • Godenschwege, T.
  • Boucrot, E.
  • Partridge, L.
(2017) PLoS Biol, 15, 9, e2001655

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

  • Gorsky, M. K.
  • Burnouf, S.
  • Sofola-Adesakin, O.
  • Dols, J.
  • Augustin, H.
  • Weigelt, C. M.
  • Gronke, S.
  • Partridge, L.
(2017) Sci Rep, 7, 1, 9984

Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan

  • Augustin, H.
  • Adcott, J.
  • Elliott, C. J. H.
  • Partridge, L.
(2017) Fly (Austin), 11, 4, 284-289

Good Ol' Fat: Links between Lipid Signaling and Longevity

  • Bustos, V.
  • Partridge, L.
(2017) Trends Biochem Sci, 42, 10, 812-823

Drug repurposing for aging research using model organisms

  • Ziehm, M.
  • Kaur, S.
  • Ivanov, D. K.
  • Ballester, P. J.
  • Marcus, D.
  • Partridge, L.
  • Thornton, J. M.
(2017) Aging Cell, 16, 5, 1006-1015

Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

  • Brandt, T.
  • Mourier, A.
  • Tain, L. S.
  • Partridge, L.
  • Larsson, N. G.
  • Kuhlbrandt, W.
(2017) Elife, 6

Genetic models of C9orf72: what is toxic?

  • Moens, T. G.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Curr Opin Genet Dev, 44, 92-101

Two forms of death in ageing Caenorhabditis elegans

  • Zhao, Y.
  • Gilliat, A. F.
  • Ziehm, M.
  • Turmaine, M.
  • Wang, H.
  • Ezcurra, M.
  • Yang, C.
  • Phillips, G.
  • McBay, D.
  • Zhang, W. B.
  • Partridge, L.
  • Pincus, Z.
  • Gems, D.
(2017) Nat Commun, 8, 15458

Myostatin-like proteins regulate synaptic function and neuronal morphology

  • Augustin, H.
  • McGourty, K.
  • Steinert, J. R.
  • Cocheme, H. M.
  • Adcott, J.
  • Cabecinha, M.
  • Vincent, A.
  • Halff, E. F.
  • Kittler, J. T.
  • Boucrot, E.
  • Partridge, L.
(2017) Development, 144, 13, 2445-2455

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

  • Mizielinska, S.
  • Ridler, C. E.
  • Balendra, R.
  • Thoeng, A.
  • Woodling, N. S.
  • Grasser, F. A.
  • Plagnol, V.
  • Lashley, T.
  • Partridge, L.
  • Isaacs, A. M.
(2017) Acta Neuropathol Commun, 5, 1, 29

2nd interventions in aging conference

  • Kennedy, B. K.
  • Partridge, L.
(2017) Aging (Albany NY), 9, 4, 1090-1095

2nd interventions in aging conference

  • Kennedy, B. K.
  • Partridge, L.
(2017) Aging (Albany NY), 9, 4, 1090-1095

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

  • Hahn, O.
  • Gronke, S.
  • Stubbs, T. M.
  • Ficz, G.
  • Hendrich, O.
  • Krueger, F.
  • Andrews, S.
  • Zhang, Q.
  • Wakelam, M. J.
  • Beyer, A.
  • Reik, W.
  • Partridge, L.
(2017) Genome Biol, 18, 1, 56

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

  • Piper, M. D.
  • Soultoukis, G. A.
  • Blanc, E.
  • Mesaros, A.
  • Herbert, S. L.
  • Juricic, P.
  • He, X.
  • Atanassov, I.
  • Salmonowicz, H.
  • Yang, M.
  • Simpson, S. J.
  • Ribeiro, C.
  • Partridge, L.
(2017) Cell Metab, 25, 3, 610-621

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease

  • Kerr, F.
  • Sofola-Adesakin, O.
  • Ivanov, D. K.
  • Gatliff, J.
  • Gomez Perez-Nievas, B.
  • Bertrand, H. C.
  • Martinez, P.
  • Callard, R.
  • Snoeren, I.
  • Cocheme, H. M.
  • Adcott, J.
  • Khericha, M.
  • Castillo-Quan, J. I.
  • Wells, G.
  • Noble, W.
  • Thornton, J.
  • Partridge, L.
(2017) PLoS Genet, 13, 3, e1006593

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

  • Kinghorn, K. J.
  • Gronke, S.
  • Castillo-Quan, J. I.
  • Woodling, N. S.
  • Li, L.
  • Sirka, E.
  • Gegg, M.
  • Mills, K.
  • Hardy, J.
  • Bjedov, I.
  • Partridge, L.
(2016) J Neurosci, 36, 46, 11654-11670

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

  • Ding, X.
  • Bloch, W.
  • Iden, S.
  • Ruegg, M. A.
  • Hall, M. N.
  • Leptin, M.
  • Partridge, L.
  • Eming, S. A.
(2016) Nat Commun, 7, 13226

pGluAbeta increases accumulation of Abeta in vivo and exacerbates its toxicity

  • Sofola-Adesakin, O.
  • Khericha, M.
  • Snoeren, I.
  • Tsuda, L.
  • Partridge, L.
(2016) Acta Neuropathol Commun, 4, 1, 109

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

  • Kakanj, P.
  • Moussian, B.
  • Gronke, S.
  • Bustos, V.
  • Eming, S. A.
  • Partridge, L.
  • Leptin, M.
(2016) Nat Commun, 7, 12972

Increased Glucose Transport into Neurons Rescues Abeta Toxicity in Drosophila

  • Niccoli, T.
  • Cabecinha, M.
  • Tillmann, A.
  • Kerr, F.
  • Wong, C. T.
  • Cardenes, D.
  • Vincent, A. J.
  • Bettedi, L.
  • Li, L.
  • Gronke, S.
  • Dols, J.
  • Partridge, L.
(2016) Curr Biol, 26, 17, 2291-300

Small nucleoli are a cellular hallmark of longevity

  • Tiku, V.
  • Jain, C.
  • Raz, Y.
  • Nakamura, S.
  • Heestand, B.
  • Liu, W.
  • Spath, M.
  • Suchiman, H. E. D.
  • Muller, R. U.
  • Slagboom, P. E.
  • Partridge, L.
  • Antebi, A.
(2016) Nat Commun, 8, 16083

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications

  • Kinghorn, K. J.
  • Castillo-Quan, J. I.
  • Li, L.
  • Bhatia, K. P.
  • Abramov, A. Y.
  • Hardy, J.
  • Partridge, L.
(2016) Brain, 139, Pt 12, e68

Dietary Protein, Metabolism, and Aging

  • Soultoukis, G. A.
  • Partridge, L.
(2016) Annu Rev Biochem, 85, 5-34

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

  • Castillo-Quan, J. I.
  • Li, L.
  • Kinghorn, K. J.
  • Ivanov, D. K.
  • Tain, L. S.
  • Slack, C.
  • Kerr, F.
  • Nespital, T.
  • Thornton, J.
  • Hardy, J.
  • Bjedov, I.
  • Partridge, L.
(2016) Cell Rep, 15, 3, 638-50

Deletion of endogenous Tau proteins is not detrimental in Drosophila

  • Burnouf, Sylvie
  • Grönke, Sebastian
  • Augustin, Hrvoje
  • Dols, Jacqueline
  • Gorsky, Marianna Karina
  • Werner, Jennifer
  • Kerr, Fiona
  • Alic, Nazif
  • Martinez, Pedro
  • Partridge, Linda
(2016) Scientific Reports, 6, 23102

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

  • Gorsky, M. K.
  • Burnouf, S.
  • Dols, J.
  • Mandelkow, E.
  • Partridge, L.
(2016) Scientific Reports, 6, 22685

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

  • Regan, Jennifer C.
  • Khericha, Mobina
  • Dobson, Adam J.
  • Bolukbasi, Ekin
  • Rattanavirotkul, Nattaphong
  • Partridge, Linda
(2016) eLife, 5, e10956

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

  • Logan, A.
  • Pell, V R
  • Shaffer, K J
  • Evans, C
  • Stanley, N J
  • Robb, E L
  • Prime, T A
  • Chouchani, E T
  • Cochemé, H M
  • Fearnley, I M
  • Vidoni, S
  • James, A M
  • Porteous, C M
  • Partridge, L
  • Krieg, T
  • Smith, R A J
  • Murphy, M P
(2016) Cell Metabolism, 23, 2, 379-385

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila

  • Afschar, Sonita
  • Toivonen, Janne M.
  • Hoffmann, Julia Marianne
  • Tain, Luke Stephen
  • Wieser, Daniela
  • Finlayson, Andrew John
  • Driege, Yasmine
  • Alic, Nazif
  • Emran, Sahar
  • Stinn, Julia
  • Froehlich, Jenny
  • Piper, Matthew D.
  • Partridge, Linda
(2016) Proceedings of the National Academy of Sciences, 113, 5, 1321-1326

Could cancer drugs provide ammunition against aging?

  • Slack, Cathy
  • Alic, Nazif
  • Partridge, Linda
(2016) Cell Cycle, 15, 2, 153-155

Gerontology: Extending the healthspan

  • Partridge, L.
(2016) Nature, 529, 7585, 154-154

Comments from the departing Editor

  • Partridge, L.
(2016) Philosophical Transactions of the Royal Society of London B: Biological Sciences, 371, 1687, 20150471

Protocols to Study Aging in Drosophila

  • Piper, M. D.
  • Partridge, L.
(2016) Methods Mol Biol, 1478, 291-302

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster

  • Iyer, J.
  • Wang, Q.
  • Le, T.
  • Pizzo, L.
  • Gronke, S.
  • Ambegaokar, S. S.
  • Imai, Y.
  • Srivastava, A.
  • Troisi, B. L.
  • Mardon, G.
  • Artero, R.
  • Jackson, G. R.
  • Isaacs, A. M.
  • Partridge, L.
  • Lu, B.
  • Kumar, J. P.
  • Girirajan, S.
(2016) G3 (Bethesda), 6, 5, 1427-37

Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice

  • Essers, P.
  • Tain, L. S.
  • Nespital, T.
  • Goncalves, J.
  • Froehlich, J.
  • Partridge, L.
(2016) Sci Rep, 6, 30290

SurvCurv database and online survival analysis platform update

  • Ziehm, M.
  • Ivanov, D. K.
  • Bhat, A.
  • Partridge, L.
  • Thornton, J. M.
(2015) Bioinformatics, 31, 23, 3878-80

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

  • Knuever, J.
  • Willenborg, S.
  • Ding, X.
  • Akyuz, M. D.
  • Partridge, L.
  • Niessen, C. M.
  • Bruning, J. C.
  • Eming, S. A.
(2015) J Immunol, 195, 11, 5296-308

Longevity GWAS Using the Drosophila Genetic Reference Panel

  • Ivanov, D. K.
  • Escott-Price, V.
  • Ziehm, M.
  • Magwire, M. M.
  • Mackay, T. F.
  • Partridge, L.
  • Thornton, J. M.
(2015) J Gerontol A Biol Sci Med Sci, 70, 12, 1470-8

Translational strategies in aging and age-related disease

  • Armanios, Mary
  • de Cabo, Rafael
  • Mannick, Joan
  • Partridge, Linda
  • van Deursen, Jan
  • Villeda, Saul
(2015) Nat Med, 21, 12, 1395-1399

Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging

  • Hoffmann, J. M.
  • Partridge, L.
(2015) Crit Rev Biochem Mol Biol, 50, 5, 380-92

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

  • Burnouf, Sylvie
  • Gorsky, MariannaKarina
  • Dols, Jacqueline
  • Grönke, Sebastian
  • Partridge, Linda
(2015) Acta Neuropathologica, 130, 1, 35-47

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

  • Menger, Katja E
  • James, Andrew M
  • Cochemé, Helena M
  • Harbour, Michael E.
  • Chouchani, Edward T
  • Ding, Shujing
  • Fearnley, Ian M
  • Partridge, Linda
  • Murphy, Michael P
(2015) Cell Reports, 11, 12, 1856-1865

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

  • Kinghorn, K. J.
  • Castillo-Quan, J. I.
  • Bartolome, F.
  • Angelova, P. R.
  • Li, L.
  • Pope, S.
  • Cocheme, H. M.
  • Khan, S.
  • Asghari, S.
  • Bhatia, K. P.
  • Hardy, J.
  • Abramov, A. Y.
  • Partridge, L.
(2015) Brain, 138, Pt 7, 1801-16

Celebrating 350 years of Philosophical Transactions: life sciences papers

  • Partridge, L.
(2015) Philos Trans R Soc Lond B Biol Sci, 370, 1666

Myc mouse and anti-ageing therapy

  • Alic, N.
  • Partridge, L.
(2015) Trends Endocrinol Metab, 26, 4, 163-4

Promoting Health and Longevity through Diet: From Model Organisms to Humans

  • Fontana, L.
  • Partridge, L.
(2015) Cell, 161, 1, 106-118

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

  • Slack, Cathy
  • Alic, Nazif
  • Foley, Andrea
  • Cabecinha, Melissa
  • Hoddinott, Matthew P
  • Partridge, Linda
(2015) Cell, 162, 1, 72-83

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

  • Bratic, A.
  • Kauppila, T. E.
  • Macao, B.
  • Gronke, S.
  • Siibak, T.
  • Stewart, J. B.
  • Baggio, F.
  • Dols, J.
  • Partridge, L.
  • Falkenberg, M.
  • Wredenberg, A.
  • Larsson, N. G.
(2015) Nat Commun, 6, 8808

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation

  • Baggio, F.
  • Bratic, A.
  • Mourier, A.
  • Kauppila, T. E.
  • Tain, L. S.
  • Kukat, C.
  • Habermann, B.
  • Partridge, L.
  • Larsson, N. G.
(2014) Nucleic Acids Res, 42, 22, 13920-38

Intervening in ageing to prevent the diseases of ageing

  • Partridge, L.
(2014) Trends Endocrinol Metab, 25, 11, 555-7

Using Doubly-Labeled Water to Measure Energy Expenditure in an Important Small Ectotherm Drosophila melanogaster

  • Piper, Matthew D. W.
  • Selman, Colin
  • Speakman, John R.
  • Partridge, Linda
(2014) Journal of Genetics and Genomics, 41, 9, 505-512

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

  • Alic, N.
  • Giannakou, M. E.
  • Papatheodorou, I.
  • Hoddinott, M. P.
  • Andrews, T. D.
  • Bolukbasi, E.
  • Partridge, L.
(2014) PLoS Genet, 10, 9, e1004619

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

  • Mizielinska, S.
  • Grönke, S.
  • Niccoli, T.
  • Ridler, C. E.
  • Clayton, E. L.
  • Devoy, A.
  • Moens, T.
  • Norona, F. E.
  • Woollacott, I. O. C.
  • Pietrzyk, J.
  • Cleverley, K.
  • Nicoll, A. J.
  • Pickering-Brown, S.
  • Dols, J.
  • Cabecinha, M.
  • Hendrich, O.
  • Fratta, P.
  • Fisher, E. M. C.
  • Partridge, L.
  • Isaacs, A. M.
(2014) Science, 345, 6201, 1192-1194

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

  • Mauer, J.
  • Chaurasia, B.
  • Goldau, J.
  • Vogt, M. C.
  • Ruud, J.
  • Nguyen, K. D.
  • Theurich, S.
  • Hausen, A. C.
  • Schmitz, J.
  • Bronneke, H. S.
  • Estevez, E.
  • Allen, T. L.
  • Mesaros, A.
  • Partridge, L.
  • Febbraio, M. A.
  • Chawla, A.
  • Wunderlich, F. T.
  • Bruning, J. C.
(2014) Nat Immunol, 15, 5, 423-30

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila

  • Metaxakis, A.
  • Tain, L. S.
  • Gronke, S.
  • Hendrich, O.
  • Hinze, Y.
  • Birras, U.
  • Partridge, L.
(2014) PLoS Biol, 12, 4, e1001824

Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

  • Alic, N.
  • Tullet, J. M.
  • Niccoli, T.
  • Broughton, S.
  • Hoddinott, M. P.
  • Slack, C.
  • Gems, D.
  • Partridge, L.
(2014) Cell Rep, 6, 4, 608-16

Editorial 2014

  • Partridge, L.
(2014) Philos Trans R Soc Lond B Biol Sci, 369, 1633, 20130496

A holidic medium for Drosophila melanogaster

  • Piper, M. D.
  • Blanc, E.
  • Leitao-Goncalves, R.
  • Yang, M.
  • He, X.
  • Linford, N. J.
  • Hoddinott, M. P.
  • Hopfen, C.
  • Soultoukis, G. A.
  • Niemeyer, C.
  • Kerr, F.
  • Pletcher, S. D.
  • Ribeiro, C.
  • Partridge, L.
(2014) Nat Methods, 11, 1, 100-5

Lithium suppresses Abeta pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

  • Sofola-Adesakin, O.
  • Castillo-Quan, J. I.
  • Rallis, C.
  • Tain, L. S.
  • Bjedov, I.
  • Rogers, I.
  • Li, L.
  • Martinez, P.
  • Khericha, M.
  • Cabecinha, M.
  • Bahler, J.
  • Partridge, L.
(2014) Front Aging Neurosci, 6, 190

MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals

  • Wredenberg, A.
  • Lagouge, M.
  • Bratic, A.
  • Metodiev, M. D.
  • Spahr, H.
  • Mourier, A.
  • Freyer, C.
  • Ruzzenente, B.
  • Tain, L.
  • Gronke, S.
  • Baggio, F.
  • Kukat, C.
  • Kremmer, E.
  • Wibom, R.
  • Polosa, P. L.
  • Habermann, B.
  • Partridge, L.
  • Park, C. B.
  • Larsson, N. G.
(2013) PLoS Genet, 9, 1, e1003178

Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster

  • Metaxakis, A.
  • Partridge, L.
(2013) PLoS ONE, 8, 9, e74681

Gender and longevity: why do men die earlier than women? Comparative and experimental evidence

  • Regan, J. C.
  • Partridge, L.
(2013) Best Pract Res Clin Endocrinol Metab, 27, 4, 467-79

The hallmarks of aging

  • Lopez-Otin, C.
  • Blasco, M. A.
  • Partridge, L.
  • Serrano, M.
  • Kroemer, G.
(2013) Cell, 153, 6, 1194-217

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

  • Chouchani, E. T.
  • Methner, C.
  • Nadtochiy, S. M.
  • Logan, A.
  • Pell, V. R.
  • Ding, S.
  • James, A. M.
  • Cocheme, H. M.
  • Reinhold, J.
  • Lilley, K. S.
  • Partridge, L.
  • Fearnley, I. M.
  • Robinson, A. J.
  • Hartley, R. C.
  • Smith, R. A.
  • Krieg, T.
  • Brookes, P. S.
  • Murphy, M. P.
(2013) Nat Med, 19, 6, 753-9

Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster

  • Lee, S. F.
  • Eyre-Walker, Y. C.
  • Rane, R. V.
  • Reuter, C.
  • Vinti, G.
  • Rako, L.
  • Partridge, L.
  • Hoffmann, A. A.
(2013) Mol Ecol, 22, 10, 2716-25

Genes, pathways and metabolism in ageing

  • Slack, Cathy
  • Partridge, Linda
(2013) Drug Discovery Today: Disease Models, 10, 2, e87-e93

Genetics of longevity in model organisms: debates and paradigm shifts

  • Gems, D.
  • Partridge, L.
(2013) Annu Rev Physiol, 75, 621-44

Diet and healthy aging

  • Partridge, L.
(2012) N Engl J Med, 367, 26, 2550-1

Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing

  • Papatheodorou, I.
  • Ziehm, M.
  • Wieser, D.
  • Alic, N.
  • Partridge, L.
  • Thornton, J. M.
(2012) PLoS ONE, 7, 12, e50881

Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females

  • Gioti, A.
  • Wigby, S.
  • Wertheim, B.
  • Schuster, E.
  • Martinez, P.
  • Pennington, C. J.
  • Partridge, L.
  • Chapman, T.
(2012) Proc Biol Sci, 279, 1746, 4423-32

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

  • Slack, C.
  • Foley, A.
  • Partridge, L.
(2012) PLoS ONE, 7, 10, e47699

Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies

  • Alic, N.
  • Hoddinott, M. P.
  • Foley, A.
  • Slack, C.
  • Piper, M. D.
  • Partridge, L.
(2012) PLoS ONE, 7, 9, e45367

Ageing as a risk factor for disease

  • Niccoli, T.
  • Partridge, L.
(2012) Curr Biol, 22, 17, R741-52

Experimental analysis of risk factors for ulcerative dermatitis in mice

  • Neuhaus, B.
  • Niessen, C. M.
  • Mesaros, A.
  • Withers, D. J.
  • Krieg, T.
  • Partridge, L.
(2012) Exp Dermatol, 21, 9, 712-3

Ageing Increases Vulnerability to Aβ42 Toxicity in

  • Rogers, Iain
  • Kerr, Fiona
  • Martinez, Pedro
  • Hardy, John
  • Lovestone, Simon
  • Partridge, Linda
(2012) PLoS ONE, 7, 7, e40569

The place of genetics in ageing research

  • Barzilai, Nir
  • Guarente, Leonard
  • Kirkwood, Thomas B. L.
  • Partridge, Linda
  • Rando, Thomas A.
  • Slagboom, P. Eline
(2012) Nat Rev Genet, 13, 8, 589-594

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

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(2012) Biochem Biophys Res Commun, 421, 2, 197-202

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

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(2012) Nat Protoc, 7, 5, 946-58

Genome-Wide Transcription Analysis of Clinal Genetic Variation in

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(2012) PLoS ONE, 7, 4, e34620

Current developments at Philosophical Transactions of the Royal Society B

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(2012) Philos Trans R Soc Lond B Biol Sci, 367, 1585, 3

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice

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(2012) Cell Cycle, 11, 1, 17-8

Death and dessert: nutrient signalling pathways and ageing

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(2011) Curr Opin Cell Biol, 23, 6, 738-43

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in

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(2011) PLoS Genet, 7, 10, e1002324

dFOXO-independent effects of reduced insulin-like signaling in Drosophila

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(2011) Aging Cell, 10, 5, 735-48

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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(2011) Nature, 477, 7365, 482-5

Dietary restriction and aging: a unifying perspective

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(2011) Cell Metab, 14, 2, 154-60

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

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(2011) Mol Syst Biol, 7, 502

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

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(2011) Exp Gerontol, 46, 5, 376-81

Unraveling the biological roles of reactive oxygen species

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(2011) Cell Metab, 13, 4, 361-6

A longer and healthier life with TOR down-regulation: genetics and drugs

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(2011) Biochem Soc Trans, 39, 2, 460-5

Molecular basis of adaptive shift in body size in

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(2011) Mol Biol Evol, 28, 8, 2393-402

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

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(2011) Cell Metab, 13, 3, 340-50

Electrophysiological recordings from the giant fiber pathway of

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(2011) J Vis Exp, 47

Insulin signalling regulates remating in female Drosophila

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(2011) Proc Biol Sci, 278, 1704, 424-31

Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1

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(2011) PLoS One, 6, 1, e16144

Some highlights of research on aging with invertebrates, 2010

  • Partridge, L.
(2011) Aging Cell, 10, 1, 5-9

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

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(2011) Aging Cell, 10, 1, 137-47

The new science of ageing

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(2011) Philos Trans R Soc Lond B Biol Sci, 366, 1561, 6-8

Comments from the new Editor

  • Partridge, Linda
(2011) Philosophical Transactions of the Royal Society B: Biological Sciences, 366, 1561, 5

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

  • Kerr, F.
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(2011) Neurobiol Aging, 32, 11, 1977-89

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

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(2010) PLoS Genet, 6, 9, e1001087

Dietary Restriction: Standing Up for Sirtuins Response

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(2010) Science, 329(5995): 1013-1013

Dietary Restriction: Theory Fails to Satiate - Response

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(2010) Science, 329(5995): 1015

Biomarkers of aging in Drosophila

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(2010) Aging Cell, 9, 4, 466-77

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

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(2010) Aging Cell, 9, 3, 336-46

Extending healthy life span--from yeast to humans

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(2010) Science, 328, 5976, 321-6

Water-independent effects of dietary restriction in Drosophila

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(2010) Proc Natl Acad Sci U S A, 107, 14, E54-6; author reply E57

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk

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(2010) PLoS Genet, 6, 3, e1000881

Molecular evolution and functional characterization of Drosophila insulin-like peptides

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(2010) PLoS Genet, 6, 2, e1000857

The new biology of ageing

  • Partridge, L.
(2010) Philos Trans R Soc Lond B Biol Sci, 365, 1537, 147-54

Mechanisms of life span extension by rapamycin in the fruit fly

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(2010) Cell Metab, 11, 1, 35-46

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

  • Grandison, R. C.
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(2009) Nature, 462, 7276, 1061-4

A Drosophila insulin-like peptide promotes growth during nonfeeding states

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(2009) Dev Cell, 17, 6, 874-84

Chemical changes in aging

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(2009) Age (Dordr), 31, 4, 343-51

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

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(2009) Proc Biol Sci, 276, 1674, 3799-807

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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(2009) Science, 326, 5949, 140-4

Invertebrate models of age-related muscle degeneration

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(2009) Biochim Biophys Acta, 1790, 10, 1084-94

Some highlights of research on aging with invertebrates, 2009

  • Partridge, L.
(2009) Aging Cell, 8, 5, 509-13

Quantification of food intake in Drosophila

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(2009) PLoS One, 4, 6, e6063

Longevity of Indy mutant Drosophila not attributable to Indy mutation

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(2009) Proc Natl Acad Sci U S A, 106, 21, E53; author reply E54

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

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(2009) Exp Gerontol, 44, 5, 316-27

Insulin/IGF-like signalling, the central nervous system and aging

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(2009) Biochem J, 418, 1, 1-12

Endocrine regulation of aging and reproduction in Drosophila

  • Toivonen, J. M.
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(2009) Mol Cell Endocrinol, 299, 1, 39-50

Effect of a standardised dietary restriction protocol on multiple laboratory strains of

  • Grandison, R. C.
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(2009) PLoS One, 4, 1, e4067

Ageing flies

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(2009) Journal of Neurogenetics, 23, S1-S1

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs

  • Broughton, S.
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(2008) PLoS One, 3, 11, e3721

Some highlights of research on aging with invertebrates, 2008

  • Partridge, L.
(2008) Aging Cell, 7, 5, 605-8

Feeding, fecundity and lifespan in female

  • Barnes, A. I.
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(2008) Proc Biol Sci, 275, 1643, 1675-83

Stage debut for the elusive Drosophila insulin-like growth factor binding protein

  • Alic, N.
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(2008) J Biol, 7, 6, 18

Toward a control theory analysis of aging

  • Murphy, M. P.
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(2008) Annu Rev Biochem, 77, 777-98

New model of health promotion and disease prevention for the 21st century

  • Butler, R. N.
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(2008) BMJ, 337, a399

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

  • Selman, C.
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(2008) Science, 320, 5879, 1012; author reply 1012

Forkhead transcription factors and ageing

  • Partridge, L.
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(2008) Oncogene, 27, 16, 2351-63

Pitfalls of measuring feeding rate in the fruit fly

  • Wong, R.
  • Piper, M. D.
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(2008) Nat Methods, 5, 3, 214-5; author reply 215

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

  • Selman, C.
  • Lingard, S.
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  • Batterham, R. L.
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  • Clements, M.
  • Ramadani, F.
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  • Schuster, E.
  • Blanc, E.
  • Piper, M. D.
  • Al-Qassab, H.
  • Speakman, J. R.
  • Carmignac, D.
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  • Gems, D.
  • Partridge, L.
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(2008) FASEB J, 22, 3, 807-18

Role of dFOXO in lifespan extension by dietary restriction in

  • Giannakou, M. E.
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  • Partridge, L.
(2008) Aging Cell, 7, 2, 187-98

Stress-response hormesis and aging: "that which does not kill us makes us stronger"

  • Gems, D.
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(2008) Cell Metab, 7, 3, 200-3

Molecular biology of aging

  • Guarente, Leonard P.
  • Partiridge, Linda
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(2008) Cold Spring Harbor monograph series, 51, VIII, 610 S.

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

  • Piper, M. D.
  • Selman, C.
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  • Partridge, L.
(2008) J Intern Med, 263, 2, 179-91

Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in

  • Milton, C. C.
  • Partridge, L.
(2008) J Insect Physiol, 54, 1, 32-40

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