Publications

Debès, C.; Papadakis, A.; Grönke, S.; Karalay, O.; Tain, L. S.; Mizi, A.; Nakamura, S.; Hahn, O.; Weigelt, C. M.; Josipovic, N. et al.; Zirkel, A.; Brusius, I.; Sofiadis, K.; Lamprousi, M.; Lu, Y.-X.; Huang, W.; Esmaillie, R.; Kubacki, T.; Späth, M. R.; Schermer, B.; Benzing, T.; Müller, R.-U.; Antebi, A.; Partridge, L.; Papantonis, A.; Beyer, A.: Ageing-associated changes in transcriptional elongation influence longevity. Nature (2023)

Baghdadi, M.; Nespital, T.; Mesaros, A.; Buschbaum, S.; Withers, D. J.; Grönke, S.; Partridge, L.: Reduced insulin signaling in neurons induces sex-specific health benefits. Science Advances 9 (2023)

Kuan, V.; Denaxas, S.; Patalay, P.; Nitsch, D.; Mathur, R.; Gonzalez-Izquierdo, A.; Sofat, R.; Partridge, L.; Roberts, A.; Wong, I. C. K. et al.; Hingorani, M.; Chaturvedi, N.; Hemingway, H.; Hingorani, A. D.; Alexander, D. C.; Asiimwe, I. G.; Ball, S.; Bennett, F.; Borges, M. C.; Butterworth, A.; Chaturvedi, N.; Chopade, S.; Clarkson, C.; Cox, M.; Dale, C.; Denaxas, S.; Dunca, D.; Engmann, J. E.; Fernandez-Sanles, A.; Finan, C.; Fitzpatrick, N.; Gallagher, J.; Gonzalez-Izquierdo, A.; Gratton, J.; Gross, C.; Hemingway, H.; Henry, A.; Hidajat, M.; Hingorani, A.; Hukerikar, N.; Jorgensen, A.; Joshi, R.; Katsoulis, M.; Kuan, V.; Kumar, R.; Lai, A. G.; Langenberg, C.; Lawlor, D.; Mancini, M.; Miller, D.; Ogden, M.; Ozyigit, E. B.; Patel, S.; Pirmohamed, M.; Roberts, A.; Ryan, D.; Schmidt, A. F.; Shah, A. D.; Shah, T.; Sofat, R.; Takhar, R.; Torralbo, A.; Ullah, A.; Walker, L. E.; Warwick, A.; Wheeler, E.; Wright, V. L.; Wu, H.; Zwierzyna, M.: Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. The Lancet Digital Health 5, pp. e16 - e27 (2023)

López-Otín, C.; Blasco, M. A.; Partridge, L.; Serrano, M.; Kroemer, G.: Hallmarks of aging: An expanding universe. Cell (2023)

Regan, J. C.; Lu, Y.-X.; Urena, E.; Meilenbrock, R. L.; Catterson, J. H.; Kißler, D.; Fröhlich, J.; Funk, E.; Partridge, L.: Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging (2), pp. 1145 - 1158 (2022)

Kuan, V.; Denaxas, S.; Patalay, P.; Nitsch, D.; Mathur, R.; Gonzalez-Izquierdo, A.; Sofat, R.; Partridge, L.; Roberts, A.; Wong, I. C. K. et al.; Hingorani, M.; Chaturvedi, N.; Hemingway, H.; Hingorani, A. D.; Multimorbidity, M.; Therapeutic Research, C.: Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. Lancet Digit Health (2022)

Romano, N.; Di Giacomo, B.; Nobile, V.; Borreca, A.; Willems, D.; Tilesi, F.; Catalani, E.; Agrawal, M.; Welshhans, K.; Ricciardi, S. et al.; Cervia, D.; Ceci, M.: Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity. Int J Mol Sci 23 (19) (2022)

Segref, A.; Vakkayil, K. L.; Padvitski, T.; Li, Q.; Kroef, V.; Lormann, J.; Korner, L.; Finger, F.; Hoppe, T.: Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Nat Commun 13 (1), p. 5874 (2022)

Laskovs, M.; Partridge, L.; Slack, C.: Molecular inhibition of RAS signalling to target ageing and age-related health. Dis Model Mech 15 (10) (2022)

Juricic, P.; Lu, Y.-X.; Leech, T.; Lisa, F.; Paulitz, J.; Lu, J.; Nespital, T.; Azami, S.; Regan, J. C.; Funk, E. et al.; Fröhlich, J.; Grönke, S.; Partridge, L.: Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging (2), pp. 824 - 836 (2022)

Srivastava, A.; Lu, J.; Gadalla, D. S.; Hendrich, O.; Grönke, S.; Partridge, L.: The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila. Front Aging 3, p. 944466 (2022)

Meron, E.; Thaysen, M.; Angeli, S.; Antebi, A.; Barzilai, N.; Baur, J. A.; Bekker-Jensen, S.; Birkisdottir, M.; Bischof, E.; Bruening, J. et al.; Brunet, A.; Buchwalter, A.; Cabreiro, F.; Cai, S.; Chen, B. H.; Ermolaeva, M.; Ewald, C. Y.; Ferrucci, L.; Florian, M. C.; Fortney, K.; Freund, A.; Georgievskaya, A.; Gladyshev, V. N.; Glass, D.; Golato, T.; Gorbunova, V.; Hoejimakers, J.; Houtkooper, R. H.; Jager, S.; Jaksch, F.; Janssens, G.; Jensen, M. B.; Kaeberlein, M.; Karsenty, G.; de Keizer, P.; Kennedy, B.; Kirkland, J. L.; Kjaer, M.; Kroemer, G.; Lee, K. F.; Lemaitre, J. M.; Liaskos, D.; Longo, V. D.; Lu, Y.-X.; MacArthur, M. R.; Maier, A. B.; Manakanatas, C.; Mitchell, S. J.; Moskalev, A.; Niedernhofer, L.; Ozerov, I.; Partridge, L.; Passegue, E.; Petr, M. A.; Peyer, J.; Radenkovic, D.; Rando, T. A.; Rattan, S.; Riedel, C. G.; Rudolph, L.; Ai, R.; Serrano, M.; Schumacher, B.; Sinclair, D. A.; Smith, R.; Suh, Y.; Taub, P.; Trapp, A.; Trendelenburg, A. U.; Valenzano, D. R.; Verburgh, K.; Verdin, E.; Vijg, J.; Westendorp, R. G. J.; Zonari, A.; Bakula, D.; Zhavoronkov, A.; Scheibye-Knudsen, M.: Meeting Report: Aging Research and Drug Discovery. Aging (Albany NY) 14 (2), pp. 530 - 543 (2022)

Baghdadi, M.; Hinterding, H. M.; Partridge, L.; Deelen, J.: From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics 1 (25), pp. 13 - 23 (2022)

Fraser, H. C.; Kuan, V.; Johnen, R.; Zwierzyna, M.; Hingorani, A. D.; Beyer, A.; Partridge, L.: Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging Cell 21 (4), p. e13524 (2022)

Nespital, T.; Neuhaus, B.; Mesaros, A.; Pahl, A.; Partridge, L.: Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell 10 (20), p. e13479 (2021)

Li, L.; Conradson, D. M.; Bharat, V.; Kim, M. J.; Hsieh, C. H.; Minhas, P. S.; Papakyrikos, A. M.; Durairaj, A. S.; Ludlam, A.; Andreasson, K. I. et al.; Partridge, L.; Cianfrocco, M. A.; Wang, X.: A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nat Metab 9 (3), pp. 1242 - 1258 (2021)

Annibal, A.; Tharyan, R. G.; Schonewolff, M. F.; Tam, H.; Latza, C.; Auler, M. M. K.; Grönke, S.; Partridge, L.; Annibal, A.: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun 12 (1), p. 3486 (2021)

Fabian, D. K.; Fuentealba, M.; Donertas, H. M.; Partridge, L.; Thornton, J. M.: Functional conservation in genes and pathways linking ageing and immunity. Immun Ageing 18 (1), p. 23 (2021)

Lu, Y.-X.; Regan, J. C.; Esser, J.; Drews, L. F.; Weinseis, T.; Stinn, J.; Hahn, O.; Miller, R. A.; Grönke, S.; Partridge, L.: A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife 10 (2021)

Dzankic, P. J.; Partridge, L.: Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults. Lancet Healthy Longev 2 (5), pp. e232 - e233 (2021)