Publications

Nespital, T.; Neuhaus, B.; Mesaros, A.; Pahl, A.; Partridge, L.: Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell 10 (20), p. e13479 (2021)

Li, L.; Conradson, D. M.; Bharat, V.; Kim, M. J.; Hsieh, C. H.; Minhas, P. S.; Papakyrikos, A. M.; Durairaj, A. S.; Ludlam, A.; Andreasson, K. I. et al.; Partridge, L.; Cianfrocco, M. A.; Wang, X.: A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nat Metab 9 (3), pp. 1242 - 1258 (2021)

Annibal, A.; Tharyan, R. G.; Schonewolff, M. F.; Tam, H.; Latza, C.; Auler, M. M. K.; Grönke, S.; Partridge, L.; Annibal, A.: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun 12 (1), p. 3486 (2021)

Fabian, D. K.; Fuentealba, M.; Donertas, H. M.; Partridge, L.; Thornton, J. M.: Functional conservation in genes and pathways linking ageing and immunity. Immun Ageing 18 (1), p. 23 (2021)

Lu, Y.-X.; Regan, J. C.; Esser, J.; Drews, L. F.; Weinseis, T.; Stinn, J.; Hahn, O.; Miller, R. A.; Grönke, S.; Partridge, L.: A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife 10 (2021)

Dzankic, P. J.; Partridge, L.: Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults. Lancet Healthy Longev 2 (5), pp. e232 - e233 (2021)

Niccoli, T.; Kerr, F.; Snoeren, I.; Fabian, D.; Aleyakpo, B.; Ivanov, D.; Sofola-Adesakin, O.; Cryar, A.; Adcott, J.; Thornton, J. et al.; Partridge, L.: Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Commun 3 (2), p. fcab053 (2021)

Donertas, H. M.; Fabian, D. K.; Valenzuela, M. F.; Partridge, L.; Thornton, J. M.: Common genetic associations between age-related diseases. Nat Aging 1 (4), pp. 400 - 412 (2021)

Tain, L.; Sehlke, R.; Meilenbrock, R. L.; Leech, T.; Paulitz, J.; Chokkalingam, M.; Nagaraj, N.; Grönke, S.; Fröhlich, J.; Atanassov, I. et al.; Mann, M.; Beyer, A.; Partridge, L.: Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife 10 (2021)

Atilano, M. L.; Grönke, S.; Niccoli, T.; Kempthorne, L.; Hahn, O.; Morón-Oset, J.; Hendrich, O.; Dyson, M.; Adams, M. L.; Hull, A. et al.; Salcher-Konrad, M. T.; Monaghan, A.; Bictash, M.; Glaria, I.; Isaacs, A. M.; Partridge, L.: Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila. Elife 10 (2021)

Kapetanou, M.; Nespital, T.; Tain, L.; Pahl, A.; Partridge, L.; Gonos, E. S.: FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity. Front Cell Dev Biol 9, p. 625715 (2021)

Bolukbasi, E.; Woodling, N. S.; Ivanov, D. K.; Adcott, J.; Foley, A.; Rajasingam, A.; Gittings, L. M.; Aleyakpo, B.; Niccoli, T.; Thornton, J. M. et al.; Partridge, L.: Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proc Natl Acad Sci U S A 118 (8) (2021)

Fabian, D. K.; Melike Donertas, H.; Fuentealba, M.; Partridge, L.; Thornton, J. M.: Transposable element landscape in Drosophila populations selected for longevity. Genome Biol Evol 13 (4), p. evab031 (2021)

Kuan, V.; Fraser, H. C.; Hingorani, M.; Denaxas, S.; Gonzalez-Izquierdo, A.; Direk, K.; Nitsch, D.; Mathur, R.; Parisinos, C. A.; Lumbers, R. T. et al.; Sofat, R.; Wong, I. C. K.; Casas, J. P.; Thornton, J. M.; Hemingway, H.; Partridge, L.; Hingorani, A. D.: Data-driven identification of ageing-related diseases from electronic health records. Sci Rep 11 (1), p. 2938 (2021)

Cox, L. S.; Bellantuono, I.; Lord, J. M.; Sapey, E.; Mannick, J. B.; Partridge, L.; Gordon, A. L.; Steves, C. J.; Witham, M. D.: Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults. Lancet Healthy Longev 1 (2), pp. e55 - e57 (2021)

Fuentealba, M.; Fabian, D. K.; Donertas, H. M.; Thornton, J. M.; Partridge, L.: Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice. Mech Ageing Dev 194, p. 111437 (2021)

Kaeser, S. A.; Lehallier, B.; Thinggaard, M.; Häsler, L.M.; Apel, A.; Bergmann, C.; Berdnik, D.; Jeune, B.; Christensen, K.; Grönke, S. et al.; Partridge, L.; Wyss-Coray, T.; Mengel-From, J.; Jucker, M.: A neuronal blood marker is associated with mortality in old age. Nature Aging 1 (2), pp. 218 - 225 (2021)

Lu, J.; Temp, U.; Müller-Hartmann, A.; Esser, J.; Grönke, S.; Partridge, L.: Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging 1 (1), pp. 60 - 72 (2021)

Pouikli, A.; Parekh, S.; Maleszewska, M.; Nikopoulou, C.; Baghdadi, M.; Tripodi, I.; Folz-Donahue, K.; Hinze, Y.; Mesaros, A.; Hoey, D. et al.; Giavalisco, P.; Dowell, R.; Partridge, L.; Tessarz, P.: Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging 1 (9), pp. 810 - 825 (2021)