Molecular Genetics of Ageing
Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. The Antebi Lab studies the regulatory mechanisms that govern these processes.
We use the nematode worm C. elegans, the African turquoise killifish Nothobranchius furzeri and human cells to study ageing. Our work brings together traditional genetic approaches with systems biology (transcriptomics, proteomics, interactomics and imaging) and state-of-the-art metabolomic and lipidomic profiling of ageing-related processes.
Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
Huang, W., Kew, C., Fernandes, SA., Löhrke, A., Han L., Demetriades, C. and Antebi, A.
(2022) Nature Aging 2, 796-808.
Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
Annibal, A., Tharyan, R., G.Schonewolff, M. F., Tam, H., Latza, C., Auler, M. M. K., Gronke, S., Partridge, L., Antebi, A.
(2021) Nat Commun, 12, 1, 3486
HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence
Gerisch, B., Tharyan, R. G., Mak, J., Denzel, S. I., Popkes-van Oepen, T., Henn, N., Antebi, A.
(2020) Dev Cell, 53, 3, 316-329 e5
Small nucleoli are a cellular hallmark of longevity
Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Spath, M., Suchiman, H. E. D., Muller, R. U., Slagboom, P. E., Partridge, L., Antebi, A.
(2017) Nat Commun, 8, 16083
Hexosamine pathway metabolites enhance protein quality control and prolong life
Denzel, M. S., Storm, N. J., Gutschmidt, A.Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T., Antebi, A.
(2014) Cell, 156, 6, 1167-78
|2020 - 2025||
ERC Advanced Grant
NuAge, Nucleolar regulation of longevity
|2020 - 2021||
DAAD, Decoding Aging Initiative
in collaboration with Mori lab, Univ Campinas, Brazil
|2018 - 2025||DFG/CECAD Cluster of Excellence Cellular Stress Responses in ageing-associated disease|
|2009 - present||
Max Planck Society Core Funding
Toxic Protein Consortium
|2018 - 2020||
Max Planck Society
Lead development of small molecule activators of GFAT-1, in collaboration with Lead Discovery Center, Dortmund
|2015 - 2020||
Prevention of neuronal protein aggregation through endogenous mechanisms
|2018 - 2019||
Decoding Aging Initiative, in collaboration with Mori lab, Univ Campinas, Brazil
|2013 - 2018||DFG/Cluster of Excellence Cellular Stress Responses in ageing-associated disease|
|2009 - 2013||DFG/Cluster of Excellence Cellular Stress Responses in ageing-associated disease|
support for GRC conference, Integrative Biology of Ageing
support for GRC conference, Integrative Biology of Ageing, co-applicant
|2010 - 2017||
SyBACol Systems Biology of Aging, Cologne, Grant
|2011 - 2015||
DFG/SFB635 project C9
Regulation of C. elegans developmental timing by the F-box protein DRE-1-FBXO11
|2011 - 2014||
Max Planck Excellence Funds
Toxic Protein Consortium
|2007 - 2011||
Ellison Medical Foundation Senior Scholar in Aging
Nuclear complexes that regulate C. elegans life stages and aging
|2006 - 2011||
A lipophilic hormone pathway regulating development and aging
|2006 - 2010||
An E3 ubiquitin ligase complex that regulates C. elegans developmental timing
Debakey Excellence in Research Award
Baylor College of Medicine
|2005 - 2007||
NIH Nuclear receptor signaling atlas (NURSA)
pilot and feasibility grant
|2005 - 2006||Baylor Seed Fund Award|
|2004 - 2006||
BMBF National Genome Research Grant 2
on Aging, Germany
|2000 - 2003||
European Community Grant
5th Framework, Agegen