Department Antebi

Molecular Genetics of Ageing

Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. The Antebi Lab studies the regulatory mechanisms that govern these processes.

We use the nematode worm C. elegans, the African turquoise killifish Nothobranchius furzeri and human cells to study ageing. Our work brings together traditional genetic approaches with systems biology (transcriptomics, proteomics, interactomics and imaging) and state-of-the-art metabolomic and lipidomic profiling of ageing-related processes.

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Selected publications

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
Huang, W., Kew, C., Fernandes, SA., Löhrke, A., Han L., Demetriades, C. and Antebi, A.
(2022) Nature Aging 2, 796-808.

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
Annibal, A., Tharyan, R., G.Schonewolff, M. F., Tam, H., Latza, C., Auler, M. M. K., Gronke, S., Partridge, L., Antebi, A.
(2021) Nat Commun, 12, 1, 3486

HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence
Gerisch, B., Tharyan, R. G., Mak, J., Denzel, S. I., Popkes-van Oepen, T., Henn, N., Antebi, A.
(2020) Dev Cell, 53, 3, 316-329 e5

Small nucleoli are a cellular hallmark of longevity
Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Spath, M., Suchiman, H. E. D., Muller, R. U., Slagboom, P. E., Partridge, L., Antebi, A.
(2017) Nat Commun, 8, 16083

Hexosamine pathway metabolites enhance protein quality control and prolong life
Denzel, M. S., Storm, N. J., Gutschmidt, A.Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T., Antebi, A.
(2014) Cell, 156, 6, 1167-78