Publications

Baghdadi, M.; Hinterding, H. M.; Gehrmann, T.; Putter, P.; Neuerburg, M.; Lakenberg, N.; van den Akker, E. B.; Slagboom, P. E.; Deelen, J.; Partridge, L.: Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants. GeroScience (2025)

Gkioni, L.; Nespital, T.; Baghdadi, M.; Monzó, C.; Bali, J.; Nassr , T.; Cremer, A. L.; Beyer, A.; Deelen, J.; Backes, H. et al.; Grönke, S.; Partridge, L.: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan. Nature Aging (2025)

Li, J. J.; Xin, N.; Yang, C.; Kim, B. G.; Tavizon, L. A.; Hong, R.; Park, J.; Moore, T. I.; Tharyan, R. G.; Antebi, A. et al.; Kim, H.-E.: Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis. PLOS Genetics 21, p. e1011700 (2025)

Kolbe, D.; Dose, J.; Putter, P.; Ziemann, M.; Laudes, M.; Slagboom, P. E.; Franke, A.; Deelen, J.; Nebel, A.: German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway. GeroScience (2025)

Malliou-Becher, M.-N.; Turnwald, E.-M.; Skupin, L.; Kretschmer, T.; Mesaros, A.; Purrio, M.; Wohlfarth, M.; Handwerk, M.; Kalis, S.; Gründermann, D. et al.; Dötsch, J.; Germeyer, A.; Appel, S.: Effect of metformin on the endometrial proteome of diet-induced obese mice. J Mol Endocrinol (2025)

Simonis, A.; Theobald, S. J.; Koch, A. E.; Mummadavarapu, R.; Mudler, J. M.; Pouikli, A.; Göbel, U.; Acton, R.; Winter, S.; Albus, A. et al.; Holzmann, D.; Albert, M.-C.; Hallek, M.; Walczak, H.; Ulas, T.; Koch, M.; Tessarz, P.; Hänsel-Hertsch, R.; Rybniker, J.: Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Molecular Systems Biology (2025)

Yamada, T.; Ikeda, A.; Murata, D.; Wang, H.; Zhang, C.; Khare, P.; Adachi, Y.; Ito, F.; Quirós, P. M.; Blackshaw, S. et al.; López-Otín, C.; Langer, T.; Chan, D. C.; Le, A.; Dawson, V. L.; Dawson, T. M.; Iijima, M.; Sesaki, H.: Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1. Nature (2025)

Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death & Disease 16, 40 (2025)

Tutas, J.; Tolve, M.; Özer-Yildiz, E.; Ickert, L.; Klein, I.; Silverman, Q.; Liebsch, F.; Dethloff, F.; Giavalisco, P.; Endepols, H. et al.; Georgomanolis, T.; Neumaier, B.; Drzezga, A.; Schwarz, G.; Thorens, B.; Gatto, G.; Frezza, C.; Kononenko, N. L.: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Nature Metabolism (2025)

Bubb, K.; Etich, J.; Probst, K.; Parashar, T.; Schuetter, M.; Dethloff, F.; Reincke, S.; Nolte, J. L.; Krüger, M.; Schlötzer-Schrehard, U. et al.; Nuechel, J.; Demetriades, C.; Giavalisco, P.; Riemer, J.; Brachvogel, B.: Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging. Science Advances 11 (2025)

Burger, N.; Mittenbühler, M. J.; Xiao, H.; Shin, S.; Wei, S. M.; Henze, E. K.; Schindler, S.; Mehravar, S.; Wood, D. M.; Petrocelli, J. J. et al.; Sun, Y.; Sprenger, H.-G.; Latorre-Muro, P.; Smythers, A. L.; Bozi, L. H.M.; Darabedian, N.; Zhu, Y.; Seo, H.-S.; Dhe-Paganon, S.; Che, J.; Chouchani, E. T.: The human zinc-binding cysteine proteome. Cell 188, pp. 832 - 850.e27 (2025)

Burgmer, S.; Meyer zu Altenschildesche, F. L.; Gyenis, A.; Lee, H. J.; Vilchez, D.; Giavalisco, P.; Fichant, A.; Uhlirova, M.; Storelli, G.: Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Reports 44, 115811, p. 115811 (2025)

Deneubourg, C.; Dafsari, H. S.; Lowe, S.; Martinez-Cotrina, A.; Mazaud, D.; Park, S. H.; Vergani, V.; Almacellas Barbanoj, A.; Maroofian, R.; Averdunk, L. et al.; Ghayoor-Karimiani, E.; Jayawant, S.; Mignot, C.; Keren, B.; Peters, R.; Kamath, A.; Mattas, L.; Verma, S.; Silwal, A.; Distelmaier, F.; Houlden, H.; Lignani, G.; Antebi, A.; Jepson, J.; Jungbluth, H.; Fanto, M.: Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis inDrosophilaand Vici syndrome patients. Autophagy 21, pp. 447 - 459 (2025)

Huppertz, I.; Mullen, A. C.: Function Over Form: Defining Evolutionarily Conserved Long-noncoding RNAs Regulating Hepatic Metabolism. Gastroenterology (2025)

Sprenger, H.-G.; Mittenbühler, M. J.; Sun, Y.; Van Vranken, J. G.; Schindler, S.; Jayaraj, A.; Khetarpal, S. A.; Smythers, A. L.; Vargas-Castillo, A.; Puszynska, A. M. et al.; Spinelli, J. B.; Armani, A.; Kunchok, T.; Ryback, B.; Seo, H.-S.; Song, K.; Sebastian, L.; O’Young, C.; Braithwaite, C.; Dhe-Paganon, S.; Burger, N.; Mills, E. L.; Gygi, S. P.; Paulo, J. A.; Arthanari, H.; Chouchani, E. T.; Sabatini, D. M.; Spiegelman, B. M.: Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. Cell Metabolism (2025)

Tiku, V.; Fakih, Z.; Tatsuta, T.; Jung, M.; Rapaport, D.; Dimmer, K. S.: Characterization of the putative yeast mitochondrial triacylglycerol lipase Tgl2. Journal of Biological Chemistry 301, 108217, p. 108217 (2025)

Perri, G.; French, C.; Agostinis-Sobrinho, C.; Anand, A.; Antarianto, R. D.; Arai, Y.; Baur, J. A.; Cauli, O.; Clivaz-Duc, M.; Colloca, G. et al.; Demetriades, C.; de Lucia, C.; Di Gessa, G.; Diniz, B. S.; Dotchin, C. L.; Eaglestone, G.; Elliott, B. T.; Espeland, M. A.; Ferrucci, L.; Fisher, J.; Grammatopoulos, D. K.; Hardiany, N. S.; Hassan-Smith, Z.; Hastings, W. J.; Jain, S.; Joshi, P. K.; Katsila, T.; Kemp, G. J.; Khaiyat, O. A.; Lamming, D. W.; Gallegos, J. L.; Madeo, F.; Maier, A. B.; Martin-Ruiz, C.; Martins, I. J.; Mathers, J. C.; Mattin, L. R.; Merchant, R. A.; Moskalev, A.; Neytchev, O.; Ni Lochlainn, M.; Owen, C. M.; Phillips, S. M.; Pratt, J.; Prokopidis, K.; Rattray, N. J. W.; Rúa-Alonso, M.; Schomburg, L.; Scott, D.; Shyam, S.; Sillanpää, E.; Tan, M. M. C.; Teh, R.; Tobin, S. W.; Vila-Chã, C. J.; Vorluni, L.; Weber, D.; Welch, A.; Wilson, D.; Wilson, T.; Zhao, T.; Philippou, E.; Korolchuk, V. I.; Shannon, O. M.: An expert consensus statement on biomarkers of ageing for use in intervention studies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences (2024)

Müller-Eigner, A.; Gille, B.; Dethloff, F.; Meng, C.; Ludwig, C.; Heiker, J. T.; Giavalisco, P.; Peleg, S.: Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. PLOS ONE 19, p. e0315892 (2024)

Gladyshev, V. N.; Anderson, B.; Barlit, H.; Barre, B.; Beck, S.; Behrouz, B.; Belsky, D. W.; Chaix, A.; Chamoli, M.; Chen, B. H. et al.; Cheng, K.; Chuprin, J.; Churchill, G. A.; Cipriano, A.; Colville, A.; Deelen, J.; Deigin, Y.; Edmonds, K. K.; English, B. W.; Fang, R.; Florea, M.; Gershteyn, I. M.; Gill, D.; Goetz, L. H.; Gorbunova, V.; Griffin, P. T.; Horvath, S.; Borch Jensen, M.; Jin, X.; Jovanovska, S.; Kajderowicz, K. M.; Kasahara, T.; Kerepesi, C.; Kulkarni, S.; Labunskyy, V. M.; Levine, M. E.; Libert, S.; Lu, J. Y.; Lu, Y. R.; Marioni, R. E.; McCoy, B. M.; Mitchell, W.; Moqri, M.; Nasirian, F.; Niimi, P.; Oh, H. S.; Okundaye, B.; Parkhitko, A. A.; Peshkin, L.; Petljak, M.; Poganik, J. R.; Pridham, G.; Promislow, D. E. L.; Prusisz, W.; Quiniou, M.; Raj, K.; Richard, D.; Ricon, J. L.; Rutledge, J.; Scheibye-Knudsen, M.; Schork, N. J.; Seluanov, A.; Shadpour, M.; Shindyapina, A. V.; Shuken, S. R.; Sivakumar, S.; Stoeger, T.; Sugiura, A.; Sutton, N. R.; Suvorov, A.; Tarkhov, A. E.; Teeling, E. C.; Trapp, A.; Tyshkovskiy, A.; Unfried, M.; Ward-Caviness, C. K.; Yim, S. H.; Ying, K.; Yunes, J.; Zhang, B.; Zhavoronkov, A.: Disagreement on foundational principles of biological aging. PNAS Nexus 3 (12), p. pgae499 (2024)

Kaade, E.; Mausbach, S.; Erps, N.; Sylvester, M.; Shakeri, F.; Jachimowicz, R. D.; Gieselmann, V.; Thelen , M.: Starvation-induced metabolic rewiring affects mTORC1 composition in vivo. Scientific Reports 14, 28296 (2024)