Publications

Nonninger, T. J.; Mak, J.; Gerisch, B.; Ramponi , V.; Kawamura, K.; Ripa, R.; Schilling, K.; Latza, C.; Kölschbach, J.; Serrano, M. et al.; Antebi, A.: A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state. Nature Aging (2025)

Glasgow, R. I. C.; Singh, V.; Peña-Pérez, L.; Wilhalm, A.; Moedas, M. F.; Moore, D.; Rosenberger, F. A.; Li, X.; Atanassov, I.; Saba, M. et al.; Cipullo, M.; Rorbach, J.; Wedell, A.; Freyer, C.; Amunts, A.; Wredenberg, A.: The mitochondrial methylation potential gates mitoribosome assembly. Nature Communications 16, 5388 (2025)

Lennicke, C.; Bjedov, I.; Grönke, S.; Menger, K. E.; James, A. M.; Castillo-Quan, J. I.; van Leeuwen, L. A. G.; Foley, A.; Buricova, M.; Adcott, J. et al.; Montoya, A.; Kramer, H. B.; Shliaha, P. V.; Logan, A.; Cabreiro, F.; Murphy, M. P.; Partridge, L.; Cochemé, H. M.: Enhancing autophagy by redox regulation extends lifespan in Drosophila. Nature Communications 16, 5379 (2025)

Düsing, P.; Göbel, I.; Ackerschott, A.; Reese, L.; Giavalisco, P.; Dethloff, F.; Niepmann, S. T.; Stei, M.; Beiert, T.; Zimmer, S. et al.; Kurts, C.; Nickenig, G.; Jansen, F.; Zietzer, A.: The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis. Cardiovascular Research (2025)

Mukherjee, R.; Bhattacharya, A.; Tomaskovic, I.; Mello-Vieira, J.; Brunstein, M. E.; Başoğlu, M.; Veenendaal, T.; Bailey, H.; Colby, T.; Misra, M. et al.; Eimer, S.; Klumperman, J.; Münch, C.; Matić, I.; Dikic, I.: Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection. The EMBO Journal (2025)

Baghdadi, M.; Hinterding, H. M.; Gehrmann, T.; Putter, P.; Neuerburg, M.; Lakenberg, N.; van den Akker, E. B.; Slagboom, P. E.; Deelen, J.; Partridge, L.: Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants. GeroScience (2025)

Gkioni, L.; Nespital, T.; Baghdadi, M.; Monzó, C.; Bali, J.; Nassr , T.; Cremer, A. L.; Beyer, A.; Deelen, J.; Backes, H. et al.; Grönke, S.; Partridge, L.: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan. Nature Aging (2025)

Li, J. J.; Xin, N.; Yang, C.; Kim, B. G.; Tavizon, L. A.; Hong, R.; Park, J.; Moore, T. I.; Tharyan, R. G.; Antebi, A. et al.; Kim, H.-E.: Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis. PLOS Genetics 21, p. e1011700 (2025)

Kolbe, D.; Dose, J.; Putter, P.; Ziemann, M.; Laudes, M.; Slagboom, P. E.; Franke, A.; Deelen, J.; Nebel, A.: German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway. GeroScience (2025)

Malliou-Becher, M.-N.; Turnwald, E.-M.; Skupin, L.; Kretschmer, T.; Mesaros, A.; Purrio, M.; Wohlfarth, M.; Handwerk, M.; Kalis, S.; Gründermann, D. et al.; Dötsch, J.; Germeyer, A.; Appel, S.: Effect of metformin on the endometrial proteome of diet-induced obese mice. J Mol Endocrinol (2025)

Simonis, A.; Theobald, S. J.; Koch, A. E.; Mummadavarapu, R.; Mudler, J. M.; Pouikli, A.; Göbel, U.; Acton, R.; Winter, S.; Albus, A. et al.; Holzmann, D.; Albert, M.-C.; Hallek, M.; Walczak, H.; Ulas, T.; Koch, M.; Tessarz, P.; Hänsel-Hertsch, R.; Rybniker, J.: Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Molecular Systems Biology (2025)

Yamada, T.; Ikeda, A.; Murata, D.; Wang, H.; Zhang, C.; Khare, P.; Adachi, Y.; Ito, F.; Quirós, P. M.; Blackshaw, S. et al.; López-Otín, C.; Langer, T.; Chan, D. C.; Le, A.; Dawson, V. L.; Dawson, T. M.; Iijima, M.; Sesaki, H.: Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1. Nature (2025)

Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death & Disease 16, 40 (2025)

Tutas, J.; Tolve, M.; Özer-Yildiz, E.; Ickert, L.; Klein, I.; Silverman, Q.; Liebsch, F.; Dethloff, F.; Giavalisco, P.; Endepols, H. et al.; Georgomanolis, T.; Neumaier, B.; Drzezga, A.; Schwarz, G.; Thorens, B.; Gatto, G.; Frezza, C.; Kononenko, N. L.: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Nature Metabolism (2025)

Koletsou, E.; Huppertz, I.: RNA-binding proteins as versatile metabolic regulators. npj Metabolic Health and Disease 3, 1 (2025)

Bubb, K.; Etich, J.; Probst, K.; Parashar, T.; Schuetter, M.; Dethloff, F.; Reincke, S.; Nolte, J. L.; Krüger, M.; Schlötzer-Schrehard, U. et al.; Nuechel, J.; Demetriades, C.; Giavalisco, P.; Riemer, J.; Brachvogel, B.: Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging. Science Advances 11 (2025)

Burger, N.; Mittenbühler, M. J.; Xiao, H.; Shin, S.; Wei, S. M.; Henze, E. K.; Schindler, S.; Mehravar, S.; Wood, D. M.; Petrocelli, J. J. et al.; Sun, Y.; Sprenger, H.-G.; Latorre-Muro, P.; Smythers, A. L.; Bozi, L. H.M.; Darabedian, N.; Zhu, Y.; Seo, H.-S.; Dhe-Paganon, S.; Che, J.; Chouchani, E. T.: The human zinc-binding cysteine proteome. Cell 188, pp. 832 - 850.e27 (2025)

Burgmer, S.; Meyer zu Altenschildesche, F. L.; Gyenis, A.; Lee, H. J.; Vilchez, D.; Giavalisco, P.; Fichant, A.; Uhlirova, M.; Storelli, G.: Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Reports 44, 115811, p. 115811 (2025)

Deneubourg, C.; Dafsari, H. S.; Lowe, S.; Martinez-Cotrina, A.; Mazaud, D.; Park, S. H.; Vergani, V.; Almacellas Barbanoj, A.; Maroofian, R.; Averdunk, L. et al.; Ghayoor-Karimiani, E.; Jayawant, S.; Mignot, C.; Keren, B.; Peters, R.; Kamath, A.; Mattas, L.; Verma, S.; Silwal, A.; Distelmaier, F.; Houlden, H.; Lignani, G.; Antebi, A.; Jepson, J.; Jungbluth, H.; Fanto, M.: Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis inDrosophilaand Vici syndrome patients. Autophagy 21, pp. 447 - 459 (2025)

Huppertz, I.; Mullen, A. C.: Function Over Form: Defining Evolutionarily Conserved Long-noncoding RNAs Regulating Hepatic Metabolism. Gastroenterology (2025)