Publications

Morón-Oset, J.; Supèr, T.; Esser, J.; Isaacs, A. M.; Grönke, S.; Partridge, L.: Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathol Commun 7 (1), p. 209 (2019)

Hahn, O.; Drews, L. F.; Nguyen, A.; Tatsuta, T.; Gkioni, L.; Hendrich, O.; Zhang, Q.; Langer, T.; Pletcher, S.; Wakelam, M. J. O. et al.; Beyer, A.; Grönke, S.; Partridge, L.: A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat Metab 1 (11), pp. 1059 - 1073 (2019)

Tain, L.; Jain, C.; Nespital, T.; Fröhlich, J.; Hinze, Y.; Grönke, S.; Partridge, L.: Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production. Aging Cell 19 (1) (2019)

Solon-Biet, S. M.; Cogger, V. C.; Pulpitel, T.; Wahl, D.; Clark, X.; Bagley, E.; Gregoriou, G. C.; Senior, A. M.; Wang, Q. P.; Brandon, A. E. et al.; Perks, R.; O'Sullivan, J.; Koay, Y. C.; Bell-Anderson, K.; Kebede, M.; Yau, B.; Atkinson, C.; Svineng, G.; Dodgson, T.; Wali, J. A.; Piper, M. D. W.; Juricic, P.; Partridge, L.; Rose, A. J.; Raubenheimer, D.; Cooney, G. J.; Le Couteur, D. G.; Simpson, S. J.: Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab 1 (5), pp. 532 - 545 (2019)

Castillo-Quan, J. I.; Tain, L.; Kinghorn, K. J.; Li, L.; Grönke, S.; Hinze, Y.; Blackwell , T. K.; Bjedov, I.; Partridge, L.: A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America 116 (42), pp. 20817 - 20819 (2019)

Yamada, S. B.; Gendron, T. F.; Niccoli, T.; Genuth, N. R.; Grosely, R.; Shi, Y.; Glaria, I.; Kramer, N. J.; Nakayama, L.; Fang, S. et al.; Dinger, T. J. I.; Thoeng, A.; Rocha, G.; Barna, M.; Puglisi, J. D.; Partridge, L.; Ichida, J. K.; Isaacs, A. M.; Petrucelli, L.; Gitler, A. D.: RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci 22 (9), pp. 1383 - 1388 (2019)

Augustin, H.; Zylbertal, A.; Partridge, L.: A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster. eNeuro 6 (2) (2019)

Juricic, P.; Grönke, S.; Partridge, L.: Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila. J Gerontol A Biol Sci Med Sci 75 (1), pp. 24 - 31 (2019)

Weigelt, C. M.; Hahn, O.; Arlt, K.; Gruhn, M.; Jahn, A. J.; Esser, J.; Werner, J. A.; Klein, C.; Buschges, A.; Grönke, S. et al.; Partridge, L.: Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sci Alliance 2 (1) (2019)

Fuentealba, M.; Donertas, H. M.; Williams, R.; Labbadia, J.; Thornton, J. M.; Partridge, L.: Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol 15 (1), p. e1006639 (2019)

Moens, T. G.; Niccoli, T.; Wilson, K. M.; Atilano, M. L.; Birsa, N.; Gittings, L. M.; Holbling, B. V.; Dyson, M. C.; Thoeng, A.; Neeves, J. et al.; Glaria, I.; Yu, L.; Bussmann, J.; Storkebaum, E.; Pardo, M.; Choudhary, J. S.; Fratta, P.; Partridge, L.; Isaacs, A. M.: C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol 137 (3), pp. 487 - 500 (2019)