Publikationen von J. B. Stewart

Järvinen, E.; Suomi, F.; Stewart, J. B.; Guala, D.; Valori, M.; Jansson, L.; Nieminen, J.; McWilliams, T. G.; Tienari, P. J.: Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine. Clinical and Experimental Immunology (2023)

Burr, S. P.; Klimm, F.; Glynos, A.; Prater, M.; Sendon, P.; Nash, P.; Powell, C. A.; Simard, M.-L.; Bonekamp, N. A.; Charl, J. et al.; Diaz, H.; Bozhilova, L. V.; Nie, Y.; Zhang, H.; Frison, M.; Falkenberg, M.; Jones, N.; Minczuk, M.; Stewart, J. B.; Chinnery, P. F.: Cell lineage-specific mitochondrial resilience during mammalian organogenesis. Cell (2023)

Saini, P. K.; Dawitz, H.; Aufschnaiter, A.; Bondarev, S.; Thomas, J.; Amblard, A.; Stewart, J. B.; Thierry-Mieg, N.; Ott, M.; Pierrel, F.: The [PSI+] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12. Mol Biol Cell, S. mbcE21100499 (2022)

Zhang, H.; Esposito, M.; Pezet, M. G.; Aryaman, J.; Wei, W.; Klimm, F.; Calabrese, C.; Burr, S. P.; Macabelli, C. H.; Viscomi, C. et al.; Saitou, M.; Chiaratti, M. R.; Stewart, J.; Jones, N.; Chinnery, P. F.: Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission. Sci Adv 7 (50), S. eabi5657 (2021)

Zekonyte, U.; Bacman, S. R.; Smith, J.; Shoop, W.; Pereira, C. V.; Tomberlin, G.; Stewart, J.; Jantz, D.; Moraes, C. T.: Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo. Nat Commun 12 (1), S. 3210 (2021)

Stewart, J.; Chinnery, P. F.: Extreme heterogeneity of human mitochondrial DNA from organelles to populations. Nat Rev Genet 22 (2), S. 106 - 118 (2021)

Isokallio, M. A.; Stewart, J.: High-Throughput Detection of mtDNA Mutations Leading to tRNA Processing Errors. Methods Mol Biol 2192, S. 117 - 132 (2021)

Saini, P. K.; Dawitz, H.; Aufschnaiter, A.; Thomas, J.; Amblard, A.; Stewart, J.; Thierry-Mieg, N.; Ott, M.; Pierrel, F.: The [PSI+] prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12. bioRxiv, S. 2021.10.08.463630 (2021)

Basu, S.; Xie, X.; Uhler, J. P.; Hedberg-Oldfors, C.; Milenkovic, D.; Baris, O. R.; Kimoloi, S.; Matic, S.; Stewart, J.; Larsson, N. G. et al.; Wiesner, R. J.; Oldfors, A.; Gustafsson, C. M.; Falkenberg, M.; Larsson, E.: Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing. PLoS Genet 16 (12), S. e1009242 (2020)

Stewart, J.: Current progress with mammalian models of mitochondrial DNA disease. J Inherit Metab Dis 44 (2), S. 325 - 342 (2020)

Filograna, R.; Koolmeister, C.; Upadhyay, M.; Pajak, A.; Clemente, P.; Wibom, R.; Simard, M. L.; Wredenberg, A.; Freyer, C.; Stewart, J. et al.; Larsson, N.G.: Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse. Sci Adv 5 (4), S. eaav9824 (2019)

Richter, U.; Ng, K. Y.; Suomi, F.; Marttinen, P.; Turunen, T.; Jackson, C.; Suomalainen, A.; Vihinen, H.; Jokitalo, E.; Nyman, T. A. et al.; Isokallio, M.; Stewart, J.; Mancini, C.; Brusco, A.; Seneca, S.; Lombes, A.; Taylor, R. W.; Battersby, B. J.: Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2 (1) (2019)

Bacman, S. R.; Kauppila, J. H. K.; Pereira, C. V.; Nissanka, N.; Miranda, M.; Pinto, M.; Williams, S. L.; Larsson, N.G.; Stewart, J.; Moraes, C. T.: Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation. Nat Med 24 (12), S. 1940 (2018)

Bacman, S. R.; Kauppila, J. H. K.; Pereira, C. V.; Nissanka, N.; Miranda, M.; Pinto, M.; Williams , S. L.; Larsson, N.G.; Stewart, J.; Moraes, C. T.: MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation. Nat Med 24 (11), S. 1696 - 1700 (2018)

Gammage, P. A.; Viscomi, C.; Simard, M.-L.; Costa, A. S. H.; Gaude, E.; Powell, C. A.; Van Haute, L.; McCann, B. J.; Rebelo-Guiomar, P.; Cerutti, R. et al.; Zhang, L.; Rebar, E. J.; Zeviani, M.; Frezza, C.; Stewart, J.; Minczuk, M.: Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nat Med 24 (11), S. 1691 - 1695 (2018)

Kauppila, J. H. K.; Bonekamp, N.; Mourier, A.; Isokallio, M.; Just, A.; Kauppila, T.; Stewart, J.; Larsson, N.G.: Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46 (13), S. 6642 - 6669 (2018)

Matic, S.; Jiang, M.; Nicholls, T. J.; Uhler, J. P.; Dirksen-Schwanenland, C.; Polosa, P. L.; Simard, M.-L.; Li, X.; Atanassov, I.; Rackham, O. et al.; Filipovska, A.; Stewart, J.; Falkenberg, M.; Larsson, N.G.; Milenkovic, D.: Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria. Nat Commun 9 (1), S. 1202 (2018)

McCann, B. J.; Cox, A.; Gammage, P. A.; Stewart, J.; Zernicka-Goetz, M.; Minczuk, M.: Delivery of mtZFNs into Early Mouse Embryos. Methods Mol Biol 1867, S. 215 - 228 (2018)

Simard, M.-L.; Mourier, A.; Greaves, L. C.; Taylor, R. W.; Stewart, J.: A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency. J Pathol 245 (3), S. 311 - 323 (2018)

Kauppila, J. H. K.; Baines, H. L.; Bratic, A.; Simard, M.-L.; Freyer, C.; Mourier, A.; Stamp, C.; Filograna, R.; Larsson, N.G.; Greaves, L. C. et al.; Stewart, J. B.: A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease. Cell Rep 16 (11), S. 2980 - 90 (2016)