Serviceeinheit Metabolomik

Publikationen

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7

  • Deshwal, S.
  • Onishi, M.
  • Tatsuta, T.
  • Bartsch, T.
  • Cors, E.
  • Ried, K.
  • Lemke, K.
  • Nolte, H.
  • Giavalisco, P.
  • Langer, T.
(2023) Nat Cell Biol

Circulating uridine dynamically and adaptively regulates food intake in humans

  • Hanssen, R.
  • Rigoux, L.
  • Albus, K.
  • Kretschmer, A. C.
  • Edwin Thanarajah, S.
  • Chen, W.
  • Hinze, Y.
  • Giavalisco, P.
  • Steculorum, S. M.
  • Cornely, O. A.
  • Bruning, J. C.
  • Tittgemeyer, M.
(2023) Cell Rep Med, 4, 1, 100897

Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics

  • Dalmasso, M. C.
  • Aran, M.
  • Galeano, P.
  • Perin, S.
  • Giavalisco, P.
  • Martino Adami, P. V.
  • Novack, G. V.
  • Castano, E. M.
  • Cuello, A. C.
  • Scherer, M.
  • Maier, W.
  • Wagner, M.
  • Riedel-Heller, S.
  • Ramirez, A.
  • Morelli, L.
(2022) Front Mol Biosci, 9, 1067296

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning

  • Stepan, J.
  • Heinz, D. E.
  • Dethloff, F.
  • Bajaj, T.
  • Zellner, A.
  • Hafner, K.
  • Wiechmann, S.
  • Mackert, S.
  • Mecdad, Y.
  • Rabenstein, M.
  • Ebert, T.
  • Martinelli, S.
  • Hausl, A. S.
  • Pohlmann, M. L.
  • Hermann, A.
  • Ma, X.
  • Pavenstadt, H.
  • Schmidt, M. V.
  • Philipsen, A.
  • Turck, C. W.
  • Deussing, J. M.
  • Kuster, B.
  • Wehr, M. C.
  • Stein, V.
  • Kremerskothen, J.
  • Wotjak, C. T.
  • Gassen, N. C.
(2022) Cell Rep, 41, 10, 111766

OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

  • Ahola, S.
  • Rivera Mejias, P.
  • Hermans, S.
  • Chandragiri, S.
  • Giavalisco, P.
  • Nolte, H.
  • Langer, T.
(2022) Cell Metab, 34, 11, 1875-1891 e7

Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication

  • Pouikli, A.
  • Maleszewska, M.
  • Parekh, S.
  • Yang, M.
  • Nikopoulou, C.
  • Bonfiglio, J. J.
  • Mylonas, C.
  • Sandoval, T.
  • Schumacher, A. L.
  • Hinze, Y.
  • Matic, I.
  • Frezza, C.
  • Tessarz, P.
(2022) EMBO J, e111239

GIGANTEA Is a Negative Regulator of Abscisic Acid Transcriptional Responses and Sensitivity in Arabidopsis

  • Siemiatkowska, B.
  • Chiara, M.
  • Badiger, B. G.
  • Riboni, M.
  • D'Avila, F.
  • Braga, D.
  • Salem, M. A. A.
  • Martignago, D.
  • Colanero, S.
  • Galbiati, M.
  • Giavalisco, P.
  • Tonelli, C.
  • Juenger, T. E.
  • Conti, L.
(2022) Plant Cell Physiol, 63, 9, 1285-1297

The TOR complex controls ATP levels to regulate actin cytoskeleton dynamics in Arabidopsis

  • Dai, L.
  • Wang, B.
  • Wang, T.
  • Meyer, E. H.
  • Kettel, V.
  • Hoffmann, N.
  • McFarlane, H. E.
  • Li, S.
  • Wu, X.
  • Picard, K. L.
  • Giavalisco, P.
  • Persson, S.
  • Zhang, Y.
(2022) Proc Natl Acad Sci U S A, 119, 38, e2122969119

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

  • Schatton, D.
  • Di Pietro, G.
  • Szczepanowska, K.
  • Veronese, M.
  • Marx, M. C.
  • Braunohler, K.
  • Barth, E.
  • Muller, S.
  • Giavalisco, P.
  • Langer, T.
  • Trifunovic, A.
  • Rugarli, E. I.
(2022) Elife, 11

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

  • Hausl, A. S.
  • Bajaj, T.
  • Brix, L. M.
  • Pohlmann, M. L.
  • Hafner, K.
  • De Angelis, M.
  • Nagler, J.
  • Dethloff, F.
  • Balsevich, G.
  • Schramm, K. W.
  • Giavalisco, P.
  • Chen, A.
  • Schmidt, M. V.
  • Gassen, N. C.
(2022) Sci Adv, 8, 10, eabi4797

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

  • Wani, G. A.
  • Sprenger, H. G.
  • Ndoci, K.
  • Chandragiri, S.
  • Acton, R. J.
  • Schatton, D.
  • Kochan, S. M. V.
  • Sakthivelu, V.
  • Jevtic, M.
  • Seeger, J. M.
  • Muller, S.
  • Giavalisco, P.
  • Rugarli, E. I.
  • Motori, E.
  • Langer, T.
  • Bergami, M.
(2022) Cell Rep, 38, 7, 110370

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen

  • Mennuni, M.
  • Filograna, R.
  • Felser, A.
  • Bonekamp, N. A.
  • Giavalisco, P.
  • Lytovchenko, O.
  • Larsson, N. G.
(2022) EMBO Rep, 23, 1, e53054

Implication of folate deficiency in CYP2U1 loss of function

  • Pujol, C.
  • Legrand, A.
  • Parodi, L.
  • Thomas, P.
  • Mochel, F.
  • Saracino, D.
  • Coarelli, G.
  • Croon, M.
  • Popovic, M.
  • Valet, M.
  • Villain, N.
  • Elshafie, S.
  • Issa, M.
  • Zuily, S.
  • Renaud, M.
  • Marelli-Tosi, C.
  • Legendre, M.
  • Trimouille, A.
  • Kemlin, I.
  • Mathieu, S.
  • Gleeson, J. G.
  • Lamari, F.
  • Galatolo, D.
  • Alkouri, R.
  • Tse, C.
  • Rodriguez, D.
  • Ewenczyk, C.
  • Fellmann, F.
  • Kuntzer, T.
  • Blond, E.
  • El Hachimi, K. H.
  • Darios, F.
  • Seyer, A.
  • Gazi, A. D.
  • Giavalisco, P.
  • Perin, S.
  • Boucher, J. L.
  • Le Corre, L.
  • Santorelli, F. M.
  • Goizet, C.
  • Zaki, M. S.
  • Picaud, S.
  • Mourier, A.
  • Steculorum, S. M.
  • Mignot, C.
  • Durr, A.
  • Trifunovic, A.
  • Stevanin, G.
(2021) J Exp Med, 218, 11

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

  • Alseekh, S.
  • Aharoni, A.
  • Brotman, Y.
  • Contrepois, K.
  • D'Auria, J.
  • Ewald, J.
  • C. Ewald J
  • Fraser, P. D.
  • Giavalisco, P.
  • Hall, R. D.
  • Heinemann, M.
  • Link, H.
  • Luo, J.
  • Neumann, S.
  • Nielsen, J.
  • Perez de Souza, L.
  • Saito, K.
  • Sauer, U.
  • Schroeder, F. C.
  • Schuster, S.
  • Siuzdak, G.
  • Skirycz, A.
  • Sumner, L. W.
  • Snyder, M. P.
  • Tang, H.
  • Tohge, T.
  • Wang, Y.
  • Wen, W.
  • Wu, S.
  • Xu, G.
  • Zamboni, N.
  • Fernie, A. R.
(2021) Nat Methods, 18, 7, 747-756

P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesity

  • Sieben, A.
  • Hausen, A. C.
  • Klemm, P.
  • Jais, A.
  • Heilinger, C.
  • Alber, J.
  • Folz-Donahue, K.
  • Schumacher, L.
  • Altmüller, J.
  • Franitza, M.
  • Giavalisco, P.
  • Hinze, Y.
  • Brodesser, S.
  • Kukat, C.
  • Theurich, S.
  • Brüning, J. C.
(2021) bioRxiv, 2021.06.23.449596

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

  • Gassen, N. C.
  • Papies, J.
  • Bajaj, T.
  • Emanuel, J.
  • Dethloff, F.
  • Chua, R. L.
  • Trimpert, J.
  • Heinemann, N.
  • Niemeyer, C.
  • Weege, F.
  • Honzke, K.
  • Aschman, T.
  • Heinz, D. E.
  • Weckmann, K.
  • Ebert, T.
  • Zellner, A.
  • Lennarz, M.
  • Wyler, E.
  • Schroeder, S.
  • Richter, A.
  • Niemeyer, D.
  • Hoffmann, K.
  • Meyer, T. F.
  • Heppner, F. L.
  • Corman, V. M.
  • Landthaler, M.
  • Hocke, A. C.
  • Morkel, M.
  • Osterrieder, N.
  • Conrad, C.
  • Eils, R.
  • Radbruch, H.
  • Giavalisco, P.
  • Drosten, C.
  • Muller, M. A.
(2021) Nat Commun, 12, 1, 3818

Reduced purine biosynthesis in humans after their divergence from Neandertals

  • Stepanova, V.
  • Moczulska, K. E.
  • Vacano, G. N.
  • Kurochkin, I.
  • Ju, X.
  • Riesenberg, S.
  • Macak, D.
  • Maricic, T.
  • Dombrowski, L.
  • Schornig, M.
  • Anastassiadis, K.
  • Baker, O.
  • Naumann, R.
  • Khrameeva, E.
  • Vanushkina, A.
  • Stekolshchikova, E.
  • Egorova, A.
  • Tkachev, A.
  • Mazzarino, R.
  • Duval, N.
  • Zubkov, D.
  • Giavalisco, P.
  • Wilkinson, T. G.
  • Patterson, D.
  • Khaitovich, P.
  • Paabo, S.
(2021) Elife, 10

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

  • Sprenger, H.-G.
  • MacVicar, T.
  • Bahat, A.
  • Fiedler, K. U.
  • Hermans, S.
  • Ehrentraut, D.
  • Ried, K.
  • Milenkovic, D.
  • Bonekamp, N.
  • Larsson, N.-G.
  • Nolte, H.
  • Giavalisco, P.
  • Langer, T.
(2021) Nature Metabolism, 3, 5, 636-650

The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters

  • Schober, F. A.
  • Moore, D.
  • Atanassov, I.
  • Moedas, M. F.
  • Clemente, P.
  • Vegvari, A.
  • Fissi, N. E.
  • Filograna, R.
  • Bucher, A. L.
  • Hinze, Y.
  • The, M.
  • Hedman, E.
  • Chernogubova, E.
  • Begzati, A.
  • Wibom, R.
  • Jain, M.
  • Nilsson, R.
  • Kall, L.
  • Wedell, A.
  • Freyer, C.
  • Wredenberg, A.
(2021) Sci Adv, 7, 8

Small-molecule inhibitors of human mitochondrial DNA transcription

  • Bonekamp, N. A.
  • Peter, B.
  • Hillen, H. S.
  • Felser, A.
  • Bergbrede, T.
  • Choidas, A.
  • Horn, M.
  • Unger, A.
  • Di Lucrezia, R.
  • Atanassov, I.
  • Li, X.
  • Koch, U.
  • Menninger, S.
  • Boros, J.
  • Habenberger, P.
  • Giavalisco, P.
  • Cramer, P.
  • Denzel, M. S.
  • Nussbaumer, P.
  • Klebl, B.
  • Falkenberg, M.
  • Gustafsson, C. M.
  • Larsson, N. G.
(2020) Nature, 588, 7839, 712-716

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

  • Kim, C. S.
  • Ding, X.
  • Allmeroth, K.
  • Biggs, L. C.
  • Kolenc, O. I.
  • L'Hoest, N.
  • Chacon-Martinez, C. A.
  • Edlich-Muth, C.
  • Giavalisco, P.
  • Quinn, K. P.
  • Denzel, M. S.
  • Eming, S. A.
  • Wickstrom, S. A.
(2020) Cell Metab, 32, 4, 629-642 e8

Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus

  • Cui, D.
  • Mesaros, A.
  • Burdeos, G.
  • Voigt, I.
  • Giavalisco, P.
  • Hinze, Y.
  • Purrio, M.
  • Neumaier, B.
  • Drzezga, A.
  • Obata, Y.
  • Endepols, H.
  • Xu, X.
(2020) Int J Mol Sci, 21, 17, 6297

Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction

  • Motori, E.
  • Atanassov, I.
  • Kochan, S. M. V.
  • Folz-Donahue, K.
  • Sakthivelu, V.
  • Giavalisco, P.
  • Toni, N.
  • Puyal, J.
  • Larsson, N. G.
(2020) Sci Adv, 6, 35, eaba8271

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

  • Timper, K.
  • Del Rio-Martin, A.
  • Cremer, A. L.
  • Bremser, S.
  • Alber, J.
  • Giavalisco, P.
  • Varela, L.
  • Heilinger, C.
  • Nolte, H.
  • Trifunovic, A.
  • Horvath, T. L.
  • Kloppenburg, P.
  • Backes, H.
  • Bruning, J. C.
(2020) Cell Metab, 31, 6, 1189-1205 e13

Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling

  • Goebel, J.
  • Engelhardt, E.
  • Pelzer, P.
  • Sakthivelu, V.
  • Jahn, H. M.
  • Jevtic, M.
  • Folz-Donahue, K.
  • Kukat, C.
  • Schauss, A.
  • Frese, C. K.
  • Giavalisco, P.
  • Ghanem, A.
  • Conzelmann, K. K.
  • Motori, E.
  • Bergami, M.
(2020) Cell Metab, 31, 4, 791-808 e8

Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production

  • Tain, L. S.
  • Jain, C.
  • Nespital, T.
  • Froehlich, J.
  • Hinze, Y.
  • Gronke, S.
  • Partridge, L.
(2020) Aging Cell, 19, 1, e13043

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

  • Schutter, M.
  • Giavalisco, P.
  • Brodesser, S.
  • Graef, M.
(2020) Cell, 180, 135-149

Differences in lipidome and metabolome organization of prefrontal cortex among human populations

  • Tkachev, A.
  • Stepanova, V.
  • Zhang, L.
  • Khrameeva, E.
  • Zubkov, D.
  • Giavalisco, P.
  • Khaitovich, P.
(2019) Sci Rep, 9, 1, 18348

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

  • Castillo-Quan, J. I.
  • Tain, L. S.
  • Kinghorn, K. J.
  • Li, L.
  • Gronke, S.
  • Hinze, Y.
  • Blackwell, T. K.
  • Bjedov, I.
  • Partridge, L.
(2019) Proc Natl Acad Sci U S A, 116, 42, 20817-20819

Metabolome signature of autism in the human prefrontal cortex

  • Kurochkin, I.
  • Khrameeva, E.
  • Tkachev, A.
  • Stepanova, V.
  • Vanyushkina, A.
  • Stekolshchikova, E.
  • Li, Q.
  • Zubkov, D.
  • Shichkova, P.
  • Halene, T.
  • Willmitzer, L.
  • Giavalisco, P.
  • Akbarian, S.
  • Khaitovich, P.
(2019) Communications Biology, 2, 234

Lipidome determinants of maximal lifespan in mammals (vol 7, 5, 2017)

  • Bozek, K.
  • Khrameeva, E. E.
  • Reznick, J.
  • Omerbasic, D.
  • Bennett, N. C.
  • Lewin, G. R.
  • Azpurua, J.
  • Gorbunova, V.
  • Seluanov, A.
  • Regnard, P.
  • Wanert, F.
  • Marchal, J.
  • Pifferi, F.
  • Aujard, F.
  • Liu, Z.
  • Shi, P.
  • Paabo, S.
  • Schroeder, F.
  • Willmitzer, L.
  • Giavalisco, P.
  • Khaitovich, P.
(2019) Scientific Reports, 9

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

  • Kuhl, I.
  • Miranda, M.
  • Atanassov, I.
  • Kuznetsova, I.
  • Hinze, Y.
  • Mourier, A.
  • Filipovska, A.
  • Larsson, N. G.
(2017) Elife, 6

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

  • Johnsen, M.
  • Spath, M. R.
  • Denzel, M. S.
  • Gobel, H.
  • Kubacki, T.
  • Hoyer, K. J.
  • Hinze, Y.
  • Benzing, T.
  • Schermer, B.
  • Antebi, A.
  • Burst, V.
  • Muller, R. U.
(2016) PLoS One, 11, 8, e0161315

Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer

  • Schottle, J.
  • Chatterjee, S.
  • Volz, C.
  • Siobal, M.
  • Florin, A.
  • Rokitta, D.
  • Hinze, Y.
  • Dietlein, F.
  • Plenker, D.
  • Konig, K.
  • Albus, K.
  • Heuckmann, J. M.
  • Rauh, D.
  • Franz, T.
  • Neumaier, B.
  • Fuhr, U.
  • Heukamp, L. C.
  • Ullrich, R. T.
(2015) Oncotarget, 6, 36, 38458-68

Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid

  • Freyer, C.
  • Stranneheim, H.
  • Naess, K.
  • Mourier, A.
  • Felser, A.
  • Maffezzini, C.
  • Lesko, N.
  • Bruhn, H.
  • Engvall, M.
  • Wibom, R.
  • Barbaro, M.
  • Hinze, Y.
  • Magnusson, M.
  • Andeer, R.
  • Zetterstrom, R. H.
  • von Dobeln, U.
  • Wredenberg, A.
  • Wedell, A.
(2015) J Med Genet, 52, 11, 779-83

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons

  • Steculorum, S. M.
  • Paeger, L.
  • Bremser, S.
  • Evers, N.
  • Hinze, Y.
  • Idzko, M.
  • Kloppenburg, P.
  • Bruning, J. C.
(2015) Cell, 162, 6, 1404-17

Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer

  • Chatterjee, S.
  • Wieczorek, C.
  • Schottle, J.
  • Siobal, M.
  • Hinze, Y.
  • Franz, T.
  • Florin, A.
  • Adamczak, J.
  • Heukamp, L. C.
  • Neumaier, B.
  • Ullrich, R. T.
(2014) Cancer Res, 74, 10, 2816-24

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila

  • Metaxakis, A.
  • Tain, L. S.
  • Gronke, S.
  • Hendrich, O.
  • Hinze, Y.
  • Birras, U.
  • Partridge, L.
(2014) PLoS Biol, 12, 4, e1001824

Hexosamine pathway metabolites enhance protein quality control and prolong life

  • Denzel, M. S.
  • Storm, N. J.
  • Gutschmidt, A.
  • Baddi, R.
  • Hinze, Y.
  • Jarosch, E.
  • Sommer, T.
  • Hoppe, T.
  • Antebi, A.
(2014) Cell, 156, 6, 1167-78