Core Facilities: Proteomics

Autosampler injects sample into an ultra high performance liquid chromatography (UPLC) for peptide separation and analysis by mass spectrometry


We provide a mass spectrometry platform with top-level instrumentation for analysing proteins, post-translational modifications and metabolites in complex biological mixtures.

Selected publications

Mourier, A., Motori, E., Brandt, T., Lagouge, M., Atanassov, I., Galinier, A., Rappl, G., Brodesser, S., Hultenby, K., Dieterich, C., et al. (2015). Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. The Journal of Cell Biology 208, 429-442.

Denzel, M.S. 1, Storm, N.J. 1, Gutschmidt, A., Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T., Antebi, A. (2014). Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell 156 (6), 1167-1178.

Hess, M.E., Hess, S., Meyer, K.D, Verhagen, L.A.W, Koch, L., Bronneke, H.S., Dietrich, M.O., Jordan, S.D., Saletore, Y., Elemento, O., Belgardt, B.F., Franz, T., Horvath, T.L., Ruther, U., Jaffrey, S.R., Kloppenburg, P., Bruning, J.C. (2013). The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature neuroscience 16 (8), 1042-1048.

Cámara, Y., Asin-Cayuela, J., Park, C.B., Metodiev, M.D., Shi, Y., Ruzzenente, B., Kukat, C., Habermann, B., Wibom, R., Hultenby, K., Franz, T., Erdjument-Bromage, H., Tempst, P., Hallberg, B.M., Gustafsson, C.M., Larsson, N.-G. (2011). MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome. Cell Metabolism 13, 527-539.