Department Antebi
Molecular Genetics of Ageing
Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. The Antebi Lab studies the regulatory mechanisms that govern these processes using the nematode worm C. elegans, the African turquoise killifish Nothobranchius furzeri and human cells. Our work brings together traditional genetic approaches with systems biology (transcriptomics, proteomics, interactomics and imaging) and state-of-the-art metabolomic and lipidomic profiling of ageing-related processes.| more |

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Contact
Selected publications
Third-party funding
- 2020-2025 | ERC Advanced Grant
NuAge, Nucleolar regulation of longevity
- 2018-2025 | DFG/CECAD Cluster of Excellence Cellular Stress Responses in ageing-associated disease
- 2018-2020 | Max Planck Society
Lead development of small molecule activators of GFAT-1, in collaboration with Lead Discovery Center, Dortmund
- 2018-2019 | DAAD
Decoding Aging Initiative, in collaboration with Mori lab, Univ Campinas, Brazil
- 2015-2020 | BMBF/EndoProtect:
Prevention of neuronal protein aggregation through endogenous mechanisms
- 2011-2015 | DFG, SFB 635: Posttranslational control of protein function
Project C9: Regulation of C. elegans Developmental Timing by the F-box Protein DRE-1/FBXO11
- 2008-present | Max Planck Society Excellence Core Funding
Toxic Protein Consortium