Department Antebi

Department Antebi

Molecular Genetics of Ageing

Ageing is defined as a gradual decline of organismal homeostasis and of physiologic functions throughout the body, and is associated with an increased risk of age-related disease. The Antebi Lab studies the regulatory mechanisms that govern these processes.

We use the nematode worm C. elegans, the African turquoise killifish Nothobranchius furzeri and human cells to study ageing. Our work brings together traditional genetic approaches with systems biology (transcriptomics, proteomics, interactomics and imaging) and state-of-the-art metabolomic and lipidomic profiling of ageing-related processes.

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Selected publications

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
Huang, W., Kew, C., Fernandes, SA., Löhrke, A., Han L., Demetriades, C. and Antebi, A.
(2022) Nature Aging 2, 796-808.

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
Annibal, A., Tharyan, R., G.Schonewolff, M. F., Tam, H., Latza, C., Auler, M. M. K., Gronke, S., Partridge, L., Antebi, A.
(2021) Nat Commun, 12, 1, 3486

HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence
Gerisch, B., Tharyan, R. G., Mak, J., Denzel, S. I., Popkes-van Oepen, T., Henn, N., Antebi, A.
(2020) Dev Cell, 53, 3, 316-329 e5

Small nucleoli are a cellular hallmark of longevity
Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Spath, M., Suchiman, H. E. D., Muller, R. U., Slagboom, P. E., Partridge, L., Antebi, A.
(2017) Nat Commun, 8, 16083

Hexosamine pathway metabolites enhance protein quality control and prolong life
Denzel, M. S., Storm, N. J., Gutschmidt, A.Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T., Antebi, A.
(2014) Cell, 156, 6, 1167-78

Third-party funding
(current)

2020 - 2025 ERC Advanced Grant
NuAge, Nucleolar regulation of longevity
2020 - 2021 DAAD, Decoding Aging Initiative
in collaboration with Mori lab, Univ Campinas, Brazil
2018 - 2025 DFG/CECAD Cluster of Excellence Cellular Stress Responses in ageing-associated disease
2009 - present  Max Planck Society Core Funding
Toxic Protein Consortium

Third-party funding
(past)

2018 - 2020                      Max Planck Society
Lead development of small molecule activators of GFAT-1, in collaboration with Lead Discovery Center, Dortmund
2015 - 2020 BMBF/EndoProtect
Prevention of neuronal protein aggregation through endogenous mechanisms
2018 - 2019 DAAD
Decoding Aging Initiative, in collaboration with Mori lab, Univ Campinas, Brazil
2013 - 2018  DFG/Cluster of Excellence Cellular Stress Responses in ageing-associated disease
2009 - 2013 DFG/Cluster of Excellence Cellular Stress Responses in ageing-associated disease
2017  Volkswagen Stiftung
support for GRC conference, Integrative Biology of Ageing
2017  NIH
support for GRC conference, Integrative Biology of Ageing, co-applicant
2010 - 2017 BMBF/GerontoSys
SyBACol Systems Biology of Aging, Cologne, Grant
2011 - 2015 DFG/SFB635 project C9
Regulation of C. elegans developmental timing by the F-box protein DRE-1-FBXO11
2011 - 2014  Max Planck Excellence Funds
Toxic Protein Consortium
2007 - 2011  Ellison Medical Foundation Senior Scholar in Aging
Nuclear complexes that regulate C. elegans life stages and aging
2006 - 2011 NIH RO1
A lipophilic hormone pathway regulating development and aging
2006 - 2010  NIH RO1
An E3 ubiquitin ligase complex that regulates C. elegans developmental timing
2007  Debakey Excellence in Research Award
Baylor College of Medicine
2005 - 2007 NIH Nuclear receptor signaling atlas (NURSA)
pilot and feasibility grant
2005 - 2006 Baylor Seed Fund Award
2004 - 2006 BMBF National Genome Research Grant 2
on Aging, Germany
2000 - 2003 European Community Grant
5th Framework, Agegen
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