The group of Nils-Göran Larsson focuses on mitochondrial genetics and the impact of mitochondrial dysfunction on disease and ageing.
Mitochondrial dysfunction is heavily implicated in the ageing process. Ageing humans have increased levels of somatic mutations in the mitochondrial genome that tend to undergo clonal expansion to cause mosaic deficiencies in the respiratory chain. The oxidative phosphorylation (OXPHOS) system produces adenosine triphosphate (ATP), the universal source of energy in all tissues. Respiratory chain dysfunction, and thus insufficient supply of ATP, can cause a variety of phenotypes associated with ageing, age-related- and mitochondrial diseases. | more |
2017-2021 | European Research Council (ERC) H2020, Advanced Grant
mtDNA-CURE: Treating mitochondrial disease caused by pathogenic mtDNA mutations
2017-2020 | DFG
SFB 1218: Mitochondrial regulation of cellular function
2013 - 2017 | DFG
CECAD: EXC 229 - to support collaborative research