Publications of N.G. Larsson

Hallberg, B. M.; Larsson, N.G.: Making proteins in the powerhouse. Cell Metab 20 (2), pp. 226 - 240 (2014)

Metodiev, M.D.; Spahr, H.; Polosa, P. L.; Meharg, C.; Becker, C.; Altmueller, J.; Habermann, B.H.; Larsson, N.G.; Ruzzenente, B.: NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly. PLOS GENETICS 10 (2), e1004110 (2014)

Sharoyko, V. V.; Abels, M.; Sun, J.; Nicholas, L. M.; Mollet, I. G.; Stamenkovic, J. A.; Göhring, I.; Malmgren, S.; Storm, P.; Fadista, J. et al.; Spégel, P.; Metodiev, M. D.; Larsson, N.G.; Eliasson, L.; Wierup, N.; Mulder, H.: Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet 23 (21), pp. 5733 - 5749 (2014)

Uhler, J. P.; Spahr, H.; Farge, G.; Clavel, S.; Larsson, N.G.; Falkenberg, M.; Samuelsson, T.; Gustafsson, C. M.: The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Biochem Biophys Res Commun 443 (1), pp. 7 - 12 (2013)

Hagstrom, E.; Freyer, C.; Battersby, B. J.; Stewart, J. B.; Larsson, N.G.: No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline. Nucleic Acids Res 42 (2), pp. 1111 - 6 (2013)

Ross, J. M.; Stewart, J. B.; Hagstrom, E.; Brene, S.; Mourier, A.; Coppotelli, G.; Freyer, C.; Lagouge, M.; Hoffer, B. J.; Olson, L. et al.; Larsson, N.G.: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 501 (7467), pp. 412 - 5 (2013)

Kukat, C.; Larsson, N.G.: mtDNA makes a U-turn for the mitochondrial nucleoid. Trends Cell Biol 23 (9), pp. 457 - 63 (2013)

Harmel, J.; Ruzzenente, B.; Terzioglu, M.; Spahr, H.; Falkenberg, M.; Larsson, N.G.: The leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) does not activate transcription in mammalian mitochondria. J Biol Chem 288 (22), pp. 15510 - 9 (2013)

Terzioglu, M.; Ruzzenente, B.; Harmel, J.; Mourier, A.; Jemt, E.; Lopez, M. D.; Kukat, C.; Stewart, J.; Wibom, R.; Meharg, C. et al.; Habermann, B.; Falkenberg, M.; Gustafsson, C. M.; Park, C. B.; Larsson, N.G.: MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab 17 (4), pp. 618 - 26 (2013)

Bratic, A.; Larsson, N.G.: The role of mitochondria in aging. J Clin Invest 123 (3), pp. 951 - 7 (2013)

Lagouge, M.; Larsson, N.G.: The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med 273 (6), pp. 529 - 43 (2013)

Naess, K.; Barbaro, M.; Bruhn, H.; Wibom, R.; Nennesmo, I.; von Dobeln, U.; Larsson, N.G.; Nemeth, A.; Lesko, N.: Complete Deletion of a POLG1 Allele in a Patient with Alpers Syndrome. JIMD Rep 4, pp. 67 - 73 (2013)

Milenkovic, D.; Matic, S.; Kühl, I.; Ruzzenente, B.; Freyer, C.; Jemt , E.; Park, C. B.; Falkenberg, M.; Larsson, N.G.: TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet 22 (10), pp. 1983 - 93 (2013)

Baggio, F.; Bratic, A.; Mourier, A.; Kukat, C.; Habermann, B.H.; Partridge, L.; Larsson, N.G.: Role of the mitochondrial protein LRPPRC2 in Drosophila melanogaster. MITOCHONDRION 13 (6), p. 909 - 909 (2013)

Wredenberg, A.; Lagouge, M.; Bratic, A.; Metodiev, M. D.; Spahr, H.; Mourier, A.; Freyer, C.; Ruzzenente, B.; Tain, L. S.; Grönke, S. et al.; Baggio, F.; Kukat, C.; Kremmer, E.; Wibom, R.; Polosa, P. L.; Habermann, B.H.; Partridge, L.; Park, C. B.; Larsson, N.G.: MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet 9 (1), p. e1003178 (2013)

Vernochet, C.; Mourier, A.; Bezy, O.; Macotela, Y.; Boucher, J.; Rardin, M. J.; An, D.; Lee, K. Y.; Ilkayeva, O. R.; Zingaretti, C. M. et al.; Emanuelli, B.; Smyth, G.; Cinti, S.; Newgard, C. B.; Gibson, B. W.; Larsson, N.G.; Kahn, C. R.: Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab 16 (6), pp. 765 - 76 (2012)

Almajan, E. R.; Richter, R.; Paeger, L.; Martinelli, P.; Barth, E.; Decker, T.; Larsson, N.G.; Kloppenburg, P.; Langer, T.; Rugarli, E. I.: AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival. J Clin Invest 122 (11), pp. 4048 - 58 (2012)

Shi, Y.; Dierckx, A.; Wanrooij, P. H.; Wanrooij, S.; Larsson, N.G.; Wilhelmsson, L. M.; Falkenberg, M.; Gustafsson, C. M.: Mammalian transcription factor A is a core component of the mitochondrial transcription machinery. Proc Natl Acad Sci U S A 109 (41), pp. 16510 - 5 (2012)

Spahr, H.; Habermann, B.; Gustafsson, C. M.; Larsson, N.G.; Hallberg, B. M.: Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. Proc Natl Acad Sci U S A 109 (38), pp. 15253 - 8 (2012)

Lee, S.; Sterky, F. H.; Mourier, A.; Terzioglu, M.; Cullheim, S.; Olson, L.; Larsson, N.G.: Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum Mol Genet 21 (22), pp. 4827 - 35 (2012)