Publications of N.G. Larsson

Ahlqvist, K. J.; Hamalainen, R. H.; Yatsuga, S.; Uutela, M.; Terzioglu, M.; Gotz, A.; Forsstrom, S.; Salven, P.; Angers-Loustau, A.; Kopra, O. H. et al.; Tyynismaa, H.; Larsson, N.G.; Wartiovaara, K.; Prolla, T.; Trifunovic, A.; Suomalainen, A.: Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab 15 (1), pp. 100 - 9 (2012)

Freyer, C.; Cree , L. M.; Mourier, A.; Stewart, J. B.; Koolmeister, C.; Milenkovic, D.; Wai, T.; Floros, V. I.; Hagstrom, E.; Chatzidaki, E. E. et al.; Wiesner, R. J.; Samuels, D. C.; Larsson, N.G.; Chinnery, P. F.: Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44 (11), pp. 1282 - 5 (2012)

Ruzzenente, B.; Metodiev, M. D.; Wredenberg, A.; Bratic, A.; Park, C. B.; Camara, Y.; Milenkovic, D.; Zickermann, V.; Wibom, R.; Hultenby, K. et al.; Erdjument-Bromage, H.; Tempst, P.; Brandt, U.; Stewart, J. B.; Gustafsson, C. M.; Larsson, N.G.: LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J 31 (2), pp. 443 - 56 (2012)

Sterky, F. H.; Hoffman, A. F.; Milenkovic, D.; Bao, B.; Paganelli, A.; Edgar, D.; Wibom, R.; Lupica, C. R.; Olson, L.; Larsson, N.G.: Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons. Hum Mol Genet 21 (5), pp. 1078 - 89 (2011)

Hallberg, B. M.; Larsson, N.G.: TFAM forces mtDNA to make a U-turn. Nat Struct Mol Biol 18 (11), pp. 1179 - 81 (2011)

Mourier, A.; Larsson, N.G.: Tracing the trail of protons through complex I of the mitochondrial respiratory chain. PLoS Biol 9 (8), p. e1001129 (2011)

Kukat, C.; Wurm, C. A.; Spahr, H.; Falkenberg, M.; Larsson, N.G.; Jakobs, S.: Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc Natl Acad Sci U S A 108 (33), pp. 13534 - 9 (2011)

Sterky, F. H.; Lee, S.; Wibom, R.; Olson, L.; Larsson, N.G.: Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A 108 (31), pp. 12937 - 42 (2011)

Park, C.B.; Larsson, N.G.: Mitochondrial DNA mutations in disease and aging. J Cell Biol 193 (5), pp. 809 - 18 (2011)

Murphy, M. P.; Holmgren, A.; Larsson, N.G.; Halliwell, B.; Chang, C. J.; Kalyanaraman, B.; Rhee, S. G.; Thornalley, P. J.; Partridge, L.; Gems, D. et al.; Nystrom, T.; Belousov, V.; Schumacker, P. T.; Winterbourn, C. C.: Unraveling the biological roles of reactive oxygen species. Cell Metab 13 (4), pp. 361 - 6 (2011)

Ameur, A.; Stewart, J. B.; Freyer, C.; Hagstrom, E.; Ingman, M.; Larsson, N.G.; Gyllensten, U.: Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins. PLoS Genet 7 (3), p. e1002028 (2011)

Andersson, D. C.; Fauconnier, J.; Park, C. B.; Zhang, S. J.; Thireau, J.; Ivarsson, N.; Larsson, N.G.; Westerblad, H.: Enhanced cardiomyocyte Ca(2+) cycling precedes terminal AV-block in mitochondrial cardiomyopathy Mterf3 KO mice. Antioxid Redox Signal 15 (9), pp. 2455 - 64 (2011)

Good, C. H.; Hoffman, A. F.; Hoffer, B. J.; Chefer, V. I.; Shippenberg, T. S.; Backman, C. M.; Larsson, N.G.; Olson, L.; Gellhaar, S.; Galter, D. et al.; Lupica, C. R.: Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. Faseb j 25 (4), pp. 1333 - 44 (2011)

Atanassova, N.; Fuste, J. M.; Wanrooij, S.; Macao, B.; Goffart, S.; Backstrom, S.; Farge, G.; Khvorostov, I.; Larsson, N.G.; Spelbrink, J. N. et al.; Falkenberg, M.: Sequence-specific stalling of DNA polymerase gamma and the effects of mutations causing progressive ophthalmoplegia. Hum Mol Genet 20 (6), pp. 1212 - 23 (2011)

Koeck, T.; Olsson, A. H.; Nitert, M. D.; Sharoyko, V. V.; Ladenvall, C.; Kotova, O.; Reiling, E.; Ronn, T.; Parikh, H.; Taneera, J. et al.; Eriksson, J. G.; Metodiev, M. D.; Larsson, N.G.; Balhuizen, A.; Luthman, H.; Stancakova, A.; Kuusisto, J.; Laakso, M.; Poulsen, P.; Vaag, A.; Groop, L.; Lyssenko, V.; Mulder, H.; Ling, C.: A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. Cell Metab 13 (1), pp. 80 - 91 (2011)

Bratic, A.; Wredenberg, A.; Grönke, S.; Stewart, J. B.; Mourier, A.; Ruzzenente, B.; Kukat, C.; Wibom, R.; Habermann, B.H.; Partridge, L. et al.; Larsson, N.G.: The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7 (10), p. e1002324 (2011)

Camara, Y.; Asin-Cayuela, J.; Park, C. B.; Metodiev, M.D.; Shi, Y.; Ruzzenente, B.; Kukat, C.; Habermann, B.H.; Wibom, R.; Hultenby, K. et al.; Franz, T.; Erdjument-Bromage, H.; Tempst, P.; Hallberg, B. M.; Gustafsson, C. M.; Larsson, N.G.: MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 13 (5), pp. 527 - 39 (2011)

Hallberg, B. M.; Larsson, N.G.: TFAM forces mtDNA to make a U-turn. Nat. Struct. Mol. Biol. 18 (11), pp. 1179 - 1181 (2011)

Ross, J. M.; Oberg, J.; Brene, S.; Coppotelli, G.; Terzioglu, M.; Pernold, K.; Goiny, M.; Sitnikov, R.; Kehr, J.; Trifunovic, A. et al.; Larsson, N.G.; Hoffer, B. J.; Olson, L.: High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proc Natl Acad Sci U S A 107 (46), pp. 20087 - 92 (2010)

Sterky, F. H.; Ruzzenente, B.; Gustafsson, C. M.; Samuelsson, T.; Larsson, N.G.: LRPPRC is a mitochondrial matrix protein that is conserved in metazoans. Biochem Biophys Res Commun 398 (4), pp. 759 - 64 (2010)