Publications of T. Langer

Ahola, S.; Rivera Mejias, P.; Hermans, S.; Chandragiri, S.; Giavalisco, P.; Nolte, H.; Langer, T.: OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metab 34 (11), pp. 1875 - 1891 e7 (2022)

Schatton, D.; Di Pietro, G.; Szczepanowska, K.; Veronese, M.; Marx, M. C.; Braunohler, K.; Barth, E.; Muller, S.; Giavalisco, P.; Langer, T. et al.; Trifunovic, A.; Rugarli, E. I.: CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Elife 11 (2022)

Wani, G. A.; Sprenger, H.-G.; Ndoci, K.; Chandragiri, S.; Acton, R. J.; Schatton, D.; Kochan, S. M. V.; Sakthivelu, V.; Jevtic, M.; Seeger, J. M. et al.; Muller, S.; Giavalisco, P.; Rugarli, E. I.; Motori, E.; Langer, T.; Bergami, M.: Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Rep 38 (7), p. 110370 (2022)

Konig, T.; Nolte, H.; Aaltonen, M. J.; Tatsuta, T.; Krols, M.; Stroh, T.; Langer, T.; McBride, H. M.: MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. Nat Cell Biol 23 (12), pp. 1271 - 1286 (2021)

Willenborg, S.; Sanin, D. E.; Jais, A.; Ding, X.; Ulas, T.; Nuechel, J.; Popovic, M.; MacVicar, T.; Langer, T.; Schultze, J. L. et al.; Gerbaulet, A.; Roers, A.; Pearce, E. J.; Bruning, J. C.; Trifunovic, A.; Eming, S. A.: Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab 33 (12), pp. 2398 - 2414.e9 (2021)

Bahat, A.; MacVicar, T.; Langer, T.: Metabolism and Innate Immunity Meet at the Mitochondria. Front Cell Dev Biol 9, p. 720490 (2021)

Murschall, L. M.; Peker, E.; MacVicar, T.; Langer, T.; Riemer, J.: Protein Import Assay into Mitochondria Isolated from Human Cells. Bio Protoc 11 (12), p. e4057 (2021)

Cretin, E.; Lopes, P.; Vimont, E.; Tatsuta, T.; Langer, T.; Gazi, A.; Sachse, M.; Yu-Wai-Man, P.; Reynier, P.; Wai, T.: High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13 (6), p. e13579 (2021)

Nolte, H.; Langer, T.: ComplexFinder: A software package for the analysis of native protein complex fractionation experiments. Biochim Biophys Acta Bioenerg 1862 (8), p. 148444 (2021)

Laborenz, J.; Bykov, Y. S.; Knoringer, K.; Raschle, M.; Filker, S.; Prescianotto-Baschong, C.; Spang, A.; Tatsuta, T.; Langer, T.; Storchova, Z. et al.; Schuldiner, M.; Herrmann, J. M.: The ER protein Ema19 facilitates the degradation of non-imported mitochondrial precursor proteins. Mol Biol Cell 32 (8), pp. 664 - 674 (2021)

Aravamudhan, S.; Turk, C.; Bock, T.; Keufgens, L.; Nolte, H.; Lang, F.; Krishnan, R. K.; Konig, T.; Hammerschmidt, P.; Schindler, N. et al.; Brodesser, S.; Rozsivalova, D. H.; Rugarli, E.; Trifunovic, A.; Bruning, J.; Langer, T.; Braun, T.; Kruger, M.: Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol 154, pp. 41 - 59 (2021)

Eiyama, A.; Aaltonen, M. J.; Nolte, H.; Tatsuta, T.; Langer, T.: Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling. J Biol Chem 296, p. 100335 (2021)

Dennerlein, S.; Poerschke, S.; Oeljeklaus, S.; Wang, C.; Richter-Dennerlein, R.; Sattmann, J.; Bauermeister, D.; Hanitsch, E.; Stoldt, S.; Langer, T. et al.; Jakobs, S.; Warscheid, B.; Rehling, P.: Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. eLife 10, p. e68213 (2021)

MacVicar, T.; Langer, T.: Mechanometabolism: Mitochondria promote resilience under pressure. Curr Biol 31 (13), pp. R859 - R861 (2021)

Sprenger, H.-G.; MacVicar, T.; Bahat, A.; Fiedler, K. U.; Hermans, S.; Ehrentraut, D.; Ried, K.; Milenkovic, D.; Bonekamp, N.; Larsson, N.G. et al.; Nolte, H.; Giavalisco, P.; Langer, T.: Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 3 (5), pp. 636 - 650 (2021)

Murschall, L. M.; Gerhards, A.; MacVicar, T.; Peker, E.; Hasberg, L.; Wawra, S.; Langer, T.; Riemer, J.: The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import. BMC Biol 18 (1), p. 96 (2020)

Deshwal, S.; Fiedler, K. U.; Langer, T.: Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity. Annu Rev Biochem 89, pp. 501 - 528 (2020)

Ohba, Y.; MacVicar, T.; Langer, T.: Regulation of mitochondrial plasticity by the i-AAA protease YME1L. Biol Chem 401 (6-7), pp. 877 - 890 (2020)

Hahn, O.; Drews, L. F.; Nguyen, A.; Tatsuta, T.; Gkioni, L.; Hendrich, O.; Zhang, Q.; Langer, T.; Pletcher, S.; Wakelam, M. J. O. et al.; Beyer, A.; Grönke, S.; Partridge, L.: A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat Metab 1 (11), pp. 1059 - 1073 (2019)

MacVicar, T.; Ohba, Y.; Nolte, H.; Mayer, F. C.; Tatsuta, T.; Sprenger, H.-G.; Lindner, B.; Zhao, Y.; Li, J.; Bruns, C. et al.; Kruger, M.; Habich, M.; Riemer, J.; Schwarzer, R.; Pasparakis, M.; Henschke, S.; Bruning, J. C.; Zamboni, N.; Langer, T.: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature 575 (7782), pp. 361 - 365 (2019)