Publications

Tutas, J.; Tolve, M.; Özer-Yildiz, E.; Ickert, L.; Klein, I.; Silverman, Q.; Liebsch, F.; Dethloff, F.; Giavalisco, P.; Endepols, H. et al.; Georgomanolis, T.; Neumaier, B.; Drzezga, A.; Schwarz, G.; Thorens, B.; Gatto, G.; Frezza, C.; Kononenko, N. L.: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Nature Metabolism (2025)

Müller-Eigner, A.; Gille, B.; Dethloff, F.; Meng, C.; Ludwig, C.; Heiker, J. T.; Giavalisco, P.; Peleg, S.: Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. PLOS ONE 19, p. e0315892 (2024)

Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S. E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

Hofer, S. J.; Daskalaki, I.; Bergmann, M.; Friščić, J.; Zimmermann, A.; Mueller, M. I.; Abdellatif, M.; Nicastro, R.; Masser, S.; Durand, S. et al.; Nartey, A.; Waltenstorfer, M.; Enzenhofer, S.; Faimann, I.; Gschiel, V.; Bajaj, T.; Niemeyer, C.; Gkikas, I.; Pein, L.; Cerrato, G.; Pan, H.; Liang, Y.; Tadic, J.; Jerkovic, A.; Aprahamian, F.; Robbins, C. E.; Nirmalathasan, N.; Habisch, H.; Annerer, E.; Dethloff, F.; Stumpe, M.; Grundler, F.; Wilhelmi de Toledo, F.; Heinz, D. E.; Koppold, D. A.; Rajput Khokhar, A.; Michalsen, A.; Tripolt, N. J.; Sourij, H.; Pieber, T. R.; de Cabo, R.; McCormick, M. A.; Magnes, C.; Kepp, O.; Dengjel, J.; Sigrist, S. J.; Gassen, N. C.; Sedej, S.; Madl, T.; De Virgilio, C.; Stelzl, U.; Hoffmann, M. H.; Eisenberg, T.; Tavernarakis, N.; Kroemer, G.; Madeo, F.: Spermidine is essential for fasting-mediated autophagy and longevity. Nature Cell Biology (2024)

Jiang, S.; Yuan, T.; Rosenberger, F. A.; Mourier, A.; Dragano, N. R. V.; Kremer, L. S.; Rubalcava-Gracia, D.; Hansen, F. M.; Borg, M.; Mennuni, M. et al.; Filograna, R.; Alsina, D.; Misic, J.; Koolmeister, C.; Papadea, P.; de Angelis, M. H.; Ren, L.; Andersson, O.; Unger, A.; Bergbrede, T.; Di Lucrezia, R.; Wibom, R.; Zierath, J. R.; Krook, A.; Giavalisco, P.; Mann, M.; Larsson, N.-G.: Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nature Metabolism (2024)

Stepan, J.; Heinz, D. E.; Dethloff, F.; Wiechmann, S.; Martinelli, S.; Hafner, K.; Ebert, T.; Junglas, E.; Häusl, A. S.; Pöhlmann, M. L. et al.; Jakovcevski, M.; Pape, J. C.; Zannas, A. S.; Bajaj, T.; Hermann, A.; Ma, X.; Pavenstädt, H.; Schmidt, M. V.; Philipsen, A.; Turck, C. W.; Deussing, J. M.; Rammes, G.; Robinson, A. C.; Payton, A.; Wehr, M. C.; Stein, V.; Murgatroyd, C.; Kremerskothen, J.; Kuster, B.; Wotjak, C. T.; Gassen, N. C.: Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. Science Signaling 17 (2024)

Nikopoulou, C.; Kleinenkuhnen, N.; Parekh, S.; Sandoval, T.; Ziegenhain, C.; Schneider, F.; Giavalisco, P.; Folz-Donahue, K.; Vesting, A. J.; Kirchner, M. et al.; Bozukova, M.; Vossen, C.; Altmüller, J.; Wunderlich, F. T.; Sandberg, R.; Kondylis, V.; Tresch, A.; Tessarz, P.: Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver. Nature Aging (2023)

Grotehans, N.; McGarry, L.; Nolte, H.; Xavier, V.; Kroker, M.; Narbona-Pérez, Á. J.; Deshwal, S.; Giavalisco, P.; Langer, T.; MacVicar, T.: Ribonucleotide synthesis byNME6fuels mitochondrial gene expression. The EMBO Journal (2023)

Aarabi, F.; Salem, M. A.; Arrivault, S.; Bulut, M.; Schöttler, M. A.; Giavalisco, P.; Fernie, A. R.; Hoefgen, R.: The regulation of sulfolipids under sulfur starvation. Plant Molecular Biology (2023)

Kim, J. Y.; Atanassov, I.; Dethloff, F.; Kroczek, L.; Langer, T.: Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria. Life science alliance 6 (9), e202302127 (2023)

Deshwal, S.; Onishi, M.; Tatsuta, T.; Bartsch, T.; Cors, E.; Ried, K.; Lemke, K.; Nolte, H.; Giavalisco, P.; Langer, T.: Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nature Cell Biology (2023)

Dalmasso, M. C.; Arán, M.; Galeano, P.; Perin, S.; Giavalisco, P.; Martino Adami, P. V.; Novack, G. V.; Castaño, E. M.; Cuello, A. C.; Scherer, M. et al.; Maier, W.; Wagner, M.; Riedel-Heller, S.; Ramirez, A.; Morelli, L.: Nicotinamide as potential biomarker for Alzheimer’s disease: A translational study based on metabolomics. Frontiers in Molecular Biosciences 9 (2023)

Chen, W.; Mehlkop, O.; Scharn, A.; Nolte, H.; Klemm, P.; Henschke, S.; Steuernagel, L.; Sotelo-Hitschfeld, T.; Kaya, E.; Wunderlich, C. M. et al.; Langer, T.; Kononenko, N. L.; Giavalisco, P.; Brüning, J. C.: Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metabolism 35, pp. 786 - 806.e13 (2023)

Hanssen, R.; Rigoux, L.; Albus, K.; Kretschmer, A. C.; Edwin Thanarajah, S.; Chen, W.; Hinze, Y.; Giavalisco, P.; Steculorum, S. M.; Cornely, O. A. et al.; Brüning, J. C.; Tittgemeyer, M.: Circulating uridine dynamically and adaptively regulates food intake in humans. Cell Reports Medicine 4, 100897, p. 100897 (2023)

Park, S.; Belfoul, A. M.; Rastelli, M.; Jang, A.; Monnoye, M.; Bae, H.; Kamitakahara, A.; Giavalisco, P.; Sun, S.; Barelle, P.-Y. et al.; Plows, J.; Jang, C.; Fodor, A.; Goran, M. I.; Bouret, S. G.: Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway. JCI Insight 8 (2023)

Rivera Mejias, P.; Narbona-Pérez, Á. J.; Hasberg, L.; Kroczek, L.; Bahat, A.; Lawo, S.; Folz-Donahue, K.; Schumacher, A. L.; Ahola, S.; Mayer, F. C. et al.; Giavalisco, P.; Nolte, H.; Lavandero, S.; Langer, T.: The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. Cell Reports 42, 112332, p. 112332 (2023)

Pouikli, A.; Maleszewska, M.; Parekh, S.; Yang, M.; Nikopoulou, C.; Bonfiglio, J. J.; Mylonas, C.; Sandoval, T.; Schumacher, A. L.; Hinze, Y. et al.; Matić, I.; Frezza, C.; Tessarz, P.: Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication. EMBO J, p. e111239 (2022)

Dai, L.; Wang, B.; Wang, T.; Meyer, E. H.; Kettel, V.; Hoffmann, N.; McFarlane, H. E.; Li, S.; Wu, X.; Picard, K. L. et al.; Giavalisco, P.; Persson, S.; Zhang, Y.: The TOR complex controls ATP levels to regulate actin cytoskeleton dynamics in Arabidopsis. Proc Natl Acad Sci U S A 119 (38), p. e2122969119 (2022)

Ahola, S.; Rivera Mejias, P.; Hermans, S.; Chandragiri, S.; Giavalisco, P.; Nolte, H.; Langer, T.: OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metab 34 (11), pp. 1875 - 1891 e7 (2022)

Schatton, D.; Di Pietro, G.; Szczepanowska, K.; Veronese, M.; Marx, M. C.; Braunohler, K.; Barth, E.; Muller, S.; Giavalisco, P.; Langer, T. et al.; Trifunovic, A.; Rugarli, E. I.: CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Elife 11 (2022)