Publications of H.-G. Sprenger

Burger, N.; Mittenbühler, M. J.; Xiao, H.; Shin, S.; Wei, S. M.; Henze, E. K.; Schindler, S.; Mehravar, S.; Wood, D. M.; Petrocelli, J. J. et al.; Sun, Y.; Sprenger, H.-G.; Latorre-Muro, P.; Smythers, A. L.; Bozi, L. H.M.; Darabedian, N.; Zhu, Y.; Seo, H.-S.; Dhe-Paganon, S.; Che, J.; Chouchani, E. T.: The human zinc-binding cysteine proteome. Cell 188, pp. 832 - 850.e27 (2025)

Sprenger, H.-G.; Mittenbühler, M. J.; Sun, Y.; Van Vranken, J. G.; Schindler, S.; Jayaraj, A.; Khetarpal, S. A.; Smythers, A. L.; Vargas-Castillo, A.; Puszynska, A. M. et al.; Spinelli, J. B.; Armani, A.; Kunchok, T.; Ryback, B.; Seo, H.-S.; Song, K.; Sebastian, L.; O’Young, C.; Braithwaite, C.; Dhe-Paganon, S.; Burger, N.; Mills, E. L.; Gygi, S. P.; Paulo, J. A.; Arthanari, H.; Chouchani, E. T.; Sabatini, D. M.; Spiegelman, B. M.: Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. Cell Metabolism (2025)

Khetarpal, S. A.; Li, H.; Vitale, T.; Rhee, J.; Grauvogel, L.; Castro, C.; Mittenbühler, M. J.; Houstis, N. E.; Vargas-Castillo, A.; Smythers, A. L. et al.; Liu, J.; Curtin, C.; Sprenger, H.-G.; Blackmore, K. A.; Kuznetsov, A.; Freeman, R.; Bogoslavski, D.; Ellinor, P. T.; Asnani, A.; Dumesic, P. A.; Puigserver, P.; Roh, J. D.; Spiegelman, B. M.; Rosenzweig, A.: Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy. bioRxiv, p. 2024.01.30.578093 (2024)

Liu, W.; Wang, Y.; Bozi, L. H. M.; Fischer, P. D.; Jedrychowski, M. P.; Xiao, H.; Wu, T.; Darabedian, N.; He, X.; Mills, E. L. et al.; Burger, N.; Shin, S.; Reddy, A.; Sprenger, H.-G.; Tran, N.; Winther, S.; Hinshaw, S. M.; Shen, J.; Seo, H.-S.; Song, K.; Xu, A. Z.; Sebastian, L.; Zhao, J. J.; Dhe-Paganon, S.; Che, J.; Gygi, S. P.; Arthanari, H.; Chouchani, E. T.: Lactate regulates cell cycle by remodelling the anaphase promoting complex. Nature 616, pp. 790 - 797 (2023)

Mittenbühler, M. J.; Jedrychowski, M. P.; Van Vranken, J. G.; Sprenger, H.-G.; Wilensky, S.; Dumesic, P. A.; Sun, Y.; Tartaglia, A.; Bogoslavski, D.; A, M. et al.; Xiao, H.; Blackmore, K. A.; Reddy, A.; Gygi, S. P.; Chouchani, E. T.; Spiegelman, B. M.: Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metabolism 35, pp. 535 - 549.e7 (2023)

Wani, G. A.; Sprenger, H.-G.; Ndoci, K.; Chandragiri, S.; Acton, R. J.; Schatton, D.; Kochan, S. M. V.; Sakthivelu, V.; Jevtic, M.; Seeger, J. M. et al.; Muller, S.; Giavalisco, P.; Rugarli, E. I.; Motori, E.; Langer, T.; Bergami, M.: Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Rep 38 (7), p. 110370 (2022)

Spinelli, J. B.; Rosen, P. C.; Sprenger, H.-G.; Puszynska, A. M.; Mann, J. L.; Roessler, J. M.; Cangelosi, A. L.; Henne, A.; Condon, K. J.; Zhang, T. et al.; Kunchok, T.; Lewis, C. A.; Chandel, N. S.; Sabatini, D. M.: Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science 374, pp. 1227 - 1237 (2021)

Sprenger, H.-G.; MacVicar, T.; Bahat, A.; Fiedler, K. U.; Hermans, S.; Ehrentraut, D.; Ried, K.; Milenkovic, D.; Bonekamp, N.; Larsson, N.G. et al.; Nolte, H.; Giavalisco, P.; Langer, T.: Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 3 (5), pp. 636 - 650 (2021)

MacVicar, T.; Ohba, Y.; Nolte, H.; Mayer, F. C.; Tatsuta, T.; Sprenger, H.-G.; Lindner, B.; Zhao, Y.; Li, J.; Bruns, C. et al.; Kruger, M.; Habich, M.; Riemer, J.; Schwarzer, R.; Pasparakis, M.; Henschke, S.; Bruning, J. C.; Zamboni, N.; Langer, T.: Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature 575 (7782), pp. 361 - 365 (2019)

Sprenger, H.-G.; Langer, T.: The Good and the Bad of Mitochondrial Breakups. Trends Cell Biol 29 (11), pp. 888 - 900 (2019)

Hammerschmidt, P.; Ostkotte, D.; Nolte, H.; Gerl, M. J.; Jais, A.; Brunner, H. L.; Sprenger, H.-G.; Awazawa, M.; Nicholls, H. T.; Turpin-Nolan, S. M. et al.; Langer, T.; Kruger, M.; Brugger, B.; Bruning, J. C.: CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell 177 (6), pp. 1536 - 1552 e23 (2019)

Mittenbühler, M. J.; Sprenger, H.-G.; Gruber, S.; Wunderlich, C. M.; Kern, L.; Brüning, J. C.; Wunderlich, F. T.: Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma. Mol Metab 17, pp. 122 - 133 (2018)

Patron, M.; Sprenger, H.-G.; Langer, T.: m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration. Cell Res 28 (3), pp. 296 - 306 (2018)

Brandt, C.; Nolte, H.; Henschke, S.; Engström Ruud, L.; Awazawa, M.; Morgan, D. A.; Gabel, P.; Sprenger, H.-G.; Hess, M. E.; Günther, S. et al.; Langer, T.; Rahmouni, K.; Fenselau, H.; Krüger, M.; Brüning, J. C.: Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell 175, pp. 1321 - 1335.e20 (2018)

Sprenger, H.-G.; Wani, G.; Hesseling, A.; Konig, T.; Patron, M.; MacVicar, T.; Ahola, S.; Wai, T.; Barth, E.; Rugarli, E. I. et al.; Bergami, M.; Langer, T.: Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med 11 (1), p. e9288 (2018)

Wai, T.; Saita, S.; Nolte, H.; Muller, S.; Konig, T.; Richter-Dennerlein, R.; Sprenger, H.-G.; Madrenas, J.; Muhlmeister, M.; Brandt, U. et al.; Kruger, M.; Langer, T.: The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep 17 (12), pp. 1844 - 1856 (2016)

Korwitz, A.; Merkwirth, C.; Richter-Dennerlein, R.; Troder, S. E.; Sprenger, H.-G.; Quiros, P. M.; Lopez-Otin, C.; Rugarli, E. I.; Langer, T.: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol 212 (2), pp. 157 - 66 (2016)

Gray, M.; Kannu, P.; Sharma, S.; Neyt, C.; Zhang, D.; Paria, N.; Daniel, P.; Whetstone, H.; Sprenger, H.-G.; Hammerschmidt, P. et al.; Weng, A.; Dupuis, L.; Jobling, R.; Mendoza-Londono, R.; Dray, M.; Su, P.; Wilson, M.; Kapur, R.; McCarthy, E.; Alman, B.; Howard, A.; Somers, G.; Marshall, C.; Manners, S.; Flanagan, A.; Rathjen, K.; Karol, L.; Crawford, H.; Markie, D.; Rios, J.; Wise, C.; Robertson, S.: Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. The American Journal of Human Genetics 97, pp. 837 - 847 (2015)