Publikationen von L. Partridge

Lu, J.; Temp, U.; Müller-Hartmann, A.; Esser, J.; Grönke, S.; Partridge, L.: Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging 1 (1), S. 60 - 72 (2021)

Pouikli, A.; Parekh, S.; Maleszewska, M.; Nikopoulou, C.; Baghdadi, M.; Tripodi, I.; Folz-Donahue, K.; Hinze, Y.; Mesaros, A.; Hoey, D. et al.; Giavalisco, P.; Dowell, R.; Partridge, L.; Tessarz, P.: Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging 1 (9), S. 810 - 825 (2021)

Bjedov, I.; Cocheme, H. M.; Foley, A.; Wieser, D.; Woodling, N. S.; Castillo-Quan, J. I.; Norvaisas, P.; Lujan, C.; Regan, J. C.; Toivonen, J. M. et al.; Murphy, M. P.; Thornton, J.; Kinghorn, K. J.; Neufeld, T. P.; Cabreiro, F.; Partridge, L.: Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS Genet 16 (11), S. e1009083 (2020)

Woodling, N. S.; Rajasingam, A.; Minkley, L. J.; Rizzo, A.; Partridge, L.: Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biol 18 (1), S. 124 (2020)

Weigelt, C. M.; Sehgal, R.; Tain, L.; Cheng, J.; Esser, J.; Pahl, A.; Dieterich, C.; Grönke, S.; Partridge, L.: An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Mol Cell 79 (2), S. 268 - 279 e5 (2020)

Yu, Y.; Niccoli, T.; Ren, Z.; Woodling, N. S.; Aleyakpo, B.; Szabadkai, G.; Partridge, L.: PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity. Hum Mol Genet 29 (14), S. 2420 - 2434 (2020)

Partridge, L.; Fuentealba, M.; Kennedy, B. K.: The quest to slow ageing through drug discovery. Nat Rev Drug Discov 19 (8), S. 513 - 532 (2020)

Woodling, N. S.; Aleyakpo, B.; Dyson, M. C.; Minkley, L. J.; Rajasingam, A.; Dobson, A. J.; Leung, K. H. C.; Pomposova, S.; Fuentealba, M.; Alic, N. et al.; Partridge, L.: The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell 19 (5), S. e13137 (2020)

Kakanj, P.; Eming, S. A.; Partridge, L.; Leptin, M.: Long-term in vivo imaging of Drosophila larvae. Nat Protoc 15 (3), S. 1158 - 1187 (2020)

Morón-Oset, J.; Supèr, T.; Esser, J.; Isaacs, A. M.; Grönke, S.; Partridge, L.: Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathol Commun 7 (1), S. 209 (2019)

Hahn, O.; Drews, L. F.; Nguyen, A.; Tatsuta, T.; Gkioni, L.; Hendrich, O.; Zhang, Q.; Langer, T.; Pletcher, S.; Wakelam, M. J. O. et al.; Beyer, A.; Grönke, S.; Partridge, L.: A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat Metab 1 (11), S. 1059 - 1073 (2019)

Tain, L.; Jain, C.; Nespital, T.; Fröhlich, J.; Hinze, Y.; Grönke, S.; Partridge, L.: Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production. Aging Cell 19 (1) (2019)

Solon-Biet, S. M.; Cogger, V. C.; Pulpitel, T.; Wahl, D.; Clark, X.; Bagley, E.; Gregoriou, G. C.; Senior, A. M.; Wang, Q. P.; Brandon, A. E. et al.; Perks, R.; O'Sullivan, J.; Koay, Y. C.; Bell-Anderson, K.; Kebede, M.; Yau, B.; Atkinson, C.; Svineng, G.; Dodgson, T.; Wali, J. A.; Piper, M. D. W.; Juricic, P.; Partridge, L.; Rose, A. J.; Raubenheimer, D.; Cooney, G. J.; Le Couteur, D. G.; Simpson, S. J.: Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab 1 (5), S. 532 - 545 (2019)

Castillo-Quan, J. I.; Tain, L.; Kinghorn, K. J.; Li, L.; Grönke, S.; Hinze, Y.; Blackwell , T. K.; Bjedov, I.; Partridge, L.: A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America 116 (42), S. 20817 - 20819 (2019)

Yamada, S. B.; Gendron, T. F.; Niccoli, T.; Genuth, N. R.; Grosely, R.; Shi, Y.; Glaria, I.; Kramer, N. J.; Nakayama, L.; Fang, S. et al.; Dinger, T. J. I.; Thoeng, A.; Rocha, G.; Barna, M.; Puglisi, J. D.; Partridge, L.; Ichida, J. K.; Isaacs, A. M.; Petrucelli, L.; Gitler, A. D.: RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci 22 (9), S. 1383 - 1388 (2019)

Augustin, H.; Zylbertal, A.; Partridge, L.: A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster. eNeuro 6 (2) (2019)

Juricic, P.; Grönke, S.; Partridge, L.: Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila. J Gerontol A Biol Sci Med Sci 75 (1), S. 24 - 31 (2019)

Weigelt, C. M.; Hahn, O.; Arlt, K.; Gruhn, M.; Jahn, A. J.; Esser, J.; Werner, J. A.; Klein, C.; Buschges, A.; Grönke, S. et al.; Partridge, L.: Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sci Alliance 2 (1) (2019)

Fuentealba, M.; Donertas, H. M.; Williams, R.; Labbadia, J.; Thornton, J. M.; Partridge, L.: Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Comput Biol 15 (1), S. e1006639 (2019)

Moens, T. G.; Niccoli, T.; Wilson, K. M.; Atilano, M. L.; Birsa, N.; Gittings, L. M.; Holbling, B. V.; Dyson, M. C.; Thoeng, A.; Neeves, J. et al.; Glaria, I.; Yu, L.; Bussmann, J.; Storkebaum, E.; Pardo, M.; Choudhary, J. S.; Fratta, P.; Partridge, L.; Isaacs, A. M.: C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol 137 (3), S. 487 - 500 (2019)