The Stewart lab will be relocating to the Wellcome Center for Mitochondrial Research at Newcastle University in the coming months. We can no longer accept lab members or
internship / project / Masters students here in Cologne.

Genome Evolution and Ageing

The accumulation of mitochondrial dysfunction with age is one of the nine classic hallmarks of the ageing process. Many different analyses have identified the age-related accumulation of cells displaying mitochondrial dysfunction in the tissues of long-lived animals. Molecular analyses have identified the accumulation of mitochondrial DNA point mutations, structural aberrations of the mitochondrial chromosome, and a decrease in the number of mtDNA copies found within each cell. The lab focuses on the following research questions – how do the mitochondria acquire these mutations? How do they clonally expand to lead to mitochondrial deficiency? What effects do these sporadic deficient cells have on organismal health and ageing?


Research Group Leader

James Stewart, PhD


Selected publications

Third-party funding

  • 2019-2022 | Human Frontier Science Program (HFSP)
    Enhancing mitochondrial DNA fidelity to improve mammalian lifespan and

  • 2016-2019 | Marie Skłodowska-Curie Action, Innovation Training Network
    REgulation of MItochondrial gene eXpression (REMIX)
  • 2013-2015 | United Mitochondrial Disease Foundation Research Grant  
    Using mtDNA mutator mouse-derived lineages to generate mouse models of human mitochondrial diseases

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