Publications acknowledging the FACS & Imaging Core Facility
A TFEB-TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state.
Nonninger TJ, Mak J, Gerisch B, Ramponi V, Kawamura K, Ripa R, Schilling K, Latza C, Kölschbach J, Serrano M, Antebi A.
(2025) Nat Aging. Jun 30; Article ID: s43587-025-00911-4.
Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone.
Kawamura K, Diederich AR, Gerisch B, Ripa R, Latza C, Steiner JD, Fernandes S, Artoni F, Meyer DH, Sant D, Oehm S, Grundmann F, Müller RU, Demetriades C, Antebi A.
(2025) bioRxiv. Apr 14; ID: 648802.
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.
Gkioni L, Nespital T, Baghdadi M, Monzó C, Bali J, Nassr T, Cremer AL, Beyer A, Deelen J, Backes H, Grönke S, Partridge L.
(2025) Nat Aging. May 28.
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.
Baghdadi M, Hinterding H, Gehrmann T, Putter P, Neuerburg M, Lakenberg N, van den Akker EB, Slagboom PE, Deelen J, Partridge L.
(2025) Geroscience. May 29.
Single-Cell Resolution of Cellular Damage Illuminates Disease Progression.
Padvitski T, Avila PA, Chen H, Özel C, Braun F, Müller RU, Westermark PO, Brinkkötter PT, Schermer B, Benzing T, Wunderlich FT, Kann M, Beyer A.
(2025) bioRxiv. Feb 20; ID: 639269.
A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut.
Puig-Barbe A, Dettmann S, Nirello VD, Moor H, Azami S, Edgar BA, Varga-Weisz P, Korzelius J, de Navascués J.
(2025) Cell Rep. Mar 25;44(3):115398.
Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity.
Izawa S, Fusca D, Jiang H, Heilinger C, Hausen AC, Wunderlich FT, Steuernagel L, Kloppenburg P, Brüning JC.
(2025) Cell Rep. Feb 25;44(2):115277.
NK2R control of energy expenditure and feeding to treat metabolic diseases.
Sass F, Ma T, Ekberg JH, Kirigiti M, Ureña MG, Dollet L, Brown JM, Basse AL, Yacawych WT, Burm HB, Andersen MK, Nielsen TS, Tomlinson AJ, Dmytiyeva O, Christensen DP, Bader L, Vo CT, Wang Y, Rausch DM, Kristensen CK, Gestal-Mato M, In Het Panhuis W, Sjøberg KA, Kernodle S, Petersen JE, Pavlovskyi A, Sandhu M, Moltke I, Jørgensen ME, Albrechtsen A, Grarup N, Babu MM, Rensen PCN, Kooijman S, Seeley RJ, Worthmann A, Heeren J, Pers TH, Hansen T, Gustafsson MBF, Tang-Christensen M, Kilpeläinen TO, Myers MG Jr, Kievit P, Schwartz TW, Hansen JB, Gerhart-Hines Z.
(2024) Nature. Nov;635(8040):987-1000.
mTORC1 activity licenses its own release from the lysosomal surface.
Acharya A, Demetriades C.
(2024) Mol Cell. Nov 21;84(22):4385-4400.e7.
Loss of killifish cGAS/STING function attenuates cellular senescence and age-related signatures but does not extend organismal life span.
Ballhysa E, Ripa R, Hochhard N, Nguyen TTM, Brazell J, Ferreri B, Hoffmann E, Steiner J, Antebi A.
(2024) bioRxiv. Oct 8; ID: 617203.
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources.
Fernandes SA, Angelidaki DD, Nüchel J, Pan J, Gollwitzer P, Elkis Y, Artoni F, Wilhelm S, Kovacevic-Sarmiento M, Demetriades C.
(2024) Nat Cell Biol. Nov;26(11):1918-1933.
Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.
Ahola S, Pazurek LA, Mayer F, Lampe P, Hermans S, Becker L, Amarie OV, Fuchs H, Gailus-Durner V, de Angelis MH, Riedel D, Nolte H, Langer T.
(2024) Sci Adv. Aug 2;10(31):eadp0443.
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
Scheiblich H, Eikens F, Wischhof L, Opitz S, Jüngling K, Cserép C, Schmidt SV, Lambertz J, Bellande T, Pósfai B, Geck C, Spitzer J, Odainic A, Castro-Gomez S, Schwartz S, Boussaad I, Krüger R, Glaab E, Di Monte DA, Bano D, Dénes Á, Latz E, Melki R, Pape HC, Heneka MT.
(2024) Neuron. Jul 23:S0896-6273(24)00491-4.
Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG.
Longarini EJ, Matić I.
(2024) Nat Commun. May 18;15(1):4239.
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
Zhang P, Catterson JH, Grönke S, Partridge L.
(2024) Nat Aging. Apr;4(4):491-509.
A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy.
Gross AS, Ghillebert R, Schuetter M, Reinartz E, Rowland A, Bishop BC, Stumpe M, Dengjel J, Graef M.
(2024) Nat Cell Biol. Mar;26(3):366-377.
An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma.
Flümann R, Hansen J, Meinel J, Pfeiffer P, Goldfarb Wittkopf H, Lütz A, Wirtz J, Möllmann M, Zhou T, Tabatabai A, Lohmann T, Jauch M, Beleggia F, Pelzer B, Ullrich F, Höfmann S, Arora A, Persigehl T, Buettner R, von Tresckow B, Klein S, Jachimowicz RD, Reinhardt HC, Knittel G.
(2023) Blood Adv. Dec 7.
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity.
Ripa R, Ballhysa E, Steiner JD, Laboy R, Annibal A, Hochhard N, Latza C, Dolfi L, Calabrese C, Meyer AM, Polidori MC, Müller RU, Antebi A.
(2023) Nat Aging. Dec;3(12):1544-1560.
I3D:bio's OMERO training material: Re-usable, adjustable, multi-purpose slides for local user training.
Schmidt C, Bortolomeazzi M, Boissonnet T, Fortmann-Grote C, Dohle J, Zentis P, Kandpal N, Kunis S, Zobel T, Weidtkamp-Peters S, Ferrando-May E.
(2023) Zenodo. Nov.
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver.
Nikopoulou C, Kleinenkuhnen N, Parekh S, Sandoval T, Ziegenhain C, Schneider F, Giavalisco P, Folz-Donahue K, Vesting AJ, Kirchner M, Bozukova M, Vossen C, Altmüller J, Wunderlich T, Sandberg R, Kondylis V, Tresch A, Tessarz P.
(2023) Nat Aging. Nov;3(11):1430-1445.
A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity.
Nonninger TJ, Mak J, Gerisch B, Ramponi V, Kawamura K, Schilling K, Latza C, Kölschbach J, Ripa R, Serrano M, Antebi A.
(2023) bioRxiv. Oct 6.
Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability.
Fernandes SA, Angelidaki DD, Nüchel J, Pan J, Gollwitzer P, Elkis Y, Artoni F, Wilhelm S, Kovacevic-Sarmiento M, Demetriades C.
(2023) bioRxiv. Oct 3.
Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence.
Averdunk L, Huetzen MA, Moreno-Andrés D, Kalb R, McKee S, Hsieh TC, Seibt A, Schouwink M, Lalani S, Faqeih EA, Brunet T, Boor P, Neveling K, Hoischen A, Hildebrandt B, Graf E, Lu L, Jin W, Schaper J, Omer JA, Demaret T, Fleischer N, Schindler D, Krawitz P, Mayatepek E, Wieczorek D, Wang LL, Antonin W, Jachimowicz RD, von Felbert V, Distelmaier F.
(2023) Genet Med. Jul;25(7):100836.
Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.
Tschernoster N, Erger F, Kohl S, Reusch B, Wenzel A, Walsh S, Thiele H, Becker C, Franitza M, Bartram MP, Kömhoff M, Schumacher L, Kukat C, Borodina T, Quedenau C, Nürnberg P, Rinschen MM, Driller JH, Pedersen BP, Schlingmann KP, Hüttel B, Bockenhauer D, Beck B, Altmüller J.
(2023) Genome Med. Aug 23;15(1):62.
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.
Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C.
(2023) Nat Cell Biol. Aug 10.
Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria.
Kim JY, Atanassov I, Dethloff F, Kroczek L, Langer T.
(2023) Life Sci Alliance. Jun 15;6(9):e202302127.
Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags.
Morón-Oset J, Fischer LK, Carcolé M, Giblin A, Zhang P, Isaacs AM, Grönke S, Partridge L.
(2023) Life Sci Alliance. Jun 12;6(9):e202201739.
Hyperspectral Confocal Imaging for High-Throughput Readout and Analysis of Bio-Integrated Laser Particles.
Titze VM, Caixeiro S, Dinh VS, König M, Rübsam M, Pathak N, Niessen CM, Schubert M, Gather MC.
(2023) Protocol Exchange
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.
Hinterding H, Baghdadi M, Gehrmann T, Putter P, Lakenberg N, van den Akker EB, Slagboom PE, Deelen J, Partridge L.
(2023) bioRxiv 2023.06.01.541708
Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor.
Artoni F, Grützmacher N, Demetriades C.
(2023) Aging Cell. Aug;22(8):e13888.
Artificial Hsp104- mediated systems for re-localizing protein aggregates.
Fischbach A, Johns A, Schneider KL, Hao X, Tessarz P, Nyström T.
(2023) Nat Commun. 2023 May 9;14(1):2663.
Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics.
Dabrowski R, Tulli S, Graef M.
(2023) J Cell Biol. 2023 Jul 3;222(7):e202211039.
Modular antibodies reveal DNA damage- induced mono-ADP-ribosylation as a second wave of PARP1 signaling.
Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I.
(2023) Mol Cell. 2023 May 18;83(10):1743-1760.e11.
The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage.
Rivera-Mejías P, Narbona-Pérez ÁJ, Hasberg L, Kroczek L, Bahat A, Lawo S, Folz-Donahue K, Schumacher AL, Ahola S, Mayer FC, Giavalisco P, Nolte H, Lavandero S, Langer T.
(2023) Cell Rep. 2023 Mar 31;42(4):112332.
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier M, Gupta M, Akgül S, McDougall M, Imhof T, Nikodemus D, Reuten R, Moya-Torres A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Mörgelin M, Poole K, Antebi A, Koch M, Stetefeld J.
(2023) Nat Commun. 2023 Mar3;14(1):1226.
Cell lineage-specific mitochondrial resilience during mammalian organogenesis
Burr, S.P., Klimm, F., Glynos, A., Prater, M., Sendon, P., Nash, P., Powell, C.A., Simard, M.L., Bonekamp, N.A., Charl, J., Diaz, H., Bozhilova, L.V., Nie, Y., Zhang, H., Frison, M., Falkenberg, M., Jones, N., Minczuk, M., Stewart, J.B., Chinnery, P.F.
(2023) Cell. 2023 Feb 17:S0092-8674(23)00093-4.
Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies
Flümann, R., Hansen, J., Pelzer, B.W., Nieper, P., Lohmann, T., Kisis, I., Riet, T., Kohlhas, V., Nguyen, P.H., Peifer, M., Abedpour, N., Bosco, G., Thomas, R.K., Kochanek, M., Knüfer, J., Jonigkeit, L., Beleggia, F., Holzem, A., Büttner, R., Lohneis, P., Meinel, J., Ortmann, M., Persigehl, T., Hallek, M., Calado, D.P., Chmielewski, M., Klein, S., Göthert, J.R., Chapuy, B., Zevnik, B., Wunderlich, F.T., von Tresckow, B., Jachimowicz, R.D., Melnick, A.M., Reinhardt, H.C., Knittel, G.
(2023) Blood Cancer Discov. 2023 Jan 6;4(1):78-97.
Refeeding-associated AMPKy1 complex activity is a hallmark of health and longevity
Ripa, R., Ballhysa, E., Steiner, J.D., Annibal, A., Hochhard, N., Latza, C., Dolfi, L., Calabrese, C., Meyer, A.M., Polidori, M.C., Müller, R.U., Antebi, A.
(2022) bioRxiv 2022.12.05.519139
A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy
Gross, A.S., Ghillebert, R., Schuetter, M., Reinartz, E., Rowland, A., Graef, M.
(2022) bioRxiv 2022.12.13.520293
Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor
Artoni, F., Grützmacher. N., Demetriades. C.
(2022) bioRxiv 2022.12.10.519872
Primary cilia suppress Ripk3-mediated necroptosis
Kieckhöfer, E., Slaats, G.G., Ebert, L.K., Albert, M.C., Dafinger, C., Kashkar, H., Benzing, T., Schermer, B.
(2022) Cell Death Discov. 2022 Dec 2;8(1):477.
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin
Regan, J.C., Lu, Y.X., Ureña, E., Meilenbrock, R.L., Catterson, J.H., Kißler, D., Fröhlich, J., Funk, E., Partridge, L.
(2022) Nat Aging 2, 1145–1158
Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor
Nicastro, R., Brohée, L., Alba, J,, Nüchel, J,, Figlia, G,, Kipschull, S., Gollwitzer, P., Romero-Pozuelo, J., Fernandes, S.A., Lamprakis, A., Vanni, S., Teleman, A.A., De Virgilio, C., Demetriades, C.
(2022) bioRxiv 2022.11.06.515351
Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics
Dabrowski, R., Tulli, S., Graef, M.
(2022) bioRxiv 2022.11.10.516013
Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication
Pouikli, A., Maleszewska. M., Parekh. S., Yang, M., Nikopoulou, C., Bonfiglio, J.J., Mylonas, C., Sandoval, T., Schumacher, A.L., Hinze, Y., Matic, I., Frezza, C., Tessarz, P.
(2022) EMBO J. 2022 Dec 1;41(23):e111239.