Publications

Research Group Deelen

Journal Article (96)

2023
Journal Article
Smulders, L.; Deelen, J.: Genetics of human longevity: From variants to genes to pathways. Journal of Internal Medicine (2023)
Journal Article
Popescu, I.; Deelen, J.; Illario, M.; Adams, J.: Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan. Journal of Cellular and Molecular Medicine (2023)
Journal Article
Astre, G.; Atlan, T.; Goshtchevsky, U.; Oron-Gottesman, A.; Smirnov, M.; Shapira, K.; Velan, A.; Deelen, J.; Levy, T.; Levanon, E. Y. et al.; Harel, I.: Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate. Developmental Cell (2023)
Journal Article
Treaster, S.; Deelen, J.; Daane, J. M.; Murabito, J.; Karasik, D.; Harris, M. P.: Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. Science Advances 9 (2023)
2022
Journal Article
Cohen, A. A.; Deelen, J.; Jones, O. R.: Editorial: Mechanisms and Pathways Contributing to the Diversity of Aging Across the Tree of Life. Front Cell Dev Biol 10, p. 854700 (2022)
Journal Article
Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2, pp. 19 - 30 (2022)
Journal Article
Baghdadi, M.; Hinterding, H. M.; Partridge, L.; Deelen, J.: From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics 1 (25), pp. 13 - 23 (2022)
Journal Article
Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2 (1), pp. 19 - 30 (2022)
2021
Journal Article
Deelen, J.: Targeting multimorbidity: Using healthspan and lifespan to identify biomarkers of ageing that pinpoint shared disease mechanisms. EBioMedicine 67, p. 103364 (2021)
Journal Article
Ahluwalia, T. S.; Prins, B. P.; Abdollahi, M.; Armstrong, N. J.; Aslibekyan, S.; Bain, L.; Jefferis, B.; Baumert, J.; Beekman, M.; Ben-Shlomo, Y. et al.; Bis, J. C.; Mitchell, B. D.; de Geus, E.; Delgado, G. E.; Marek, D.; Eriksson, J.; Kajantie, E.; Kanoni, S.; Kemp, J. P.; Lu, C.; Marioni, R. E.; McLachlan, S.; Milaneschi, Y.; Nolte, I. M.; Petrelis, A. M.; Porcu, E.; Sabater-Lleal, M.; Naderi, E.; Seppala, I.; Shah, T.; Singhal, G.; Standl, M.; Teumer, A.; Thalamuthu, A.; Thiering, E.; Trompet, S.; Ballantyne, C. M.; Benjamin, E. J.; Casas, J. P.; Toben, C.; Dedoussis, G.; Deelen, J.; Durda, P.; Engmann, J.; Feitosa, M. F.; Grallert, H.; Hammarstedt, A.; Harris, S. E.; Homuth, G.; Hottenga, J. J.; Jalkanen, S.; Jamshidi, Y.; Jawahar, M. C.; Jess, T.; Kivimaki, M.; Kleber, M. E.; Lahti, J.; Liu, Y.; Marques-Vidal, P.; Mellstrom, D.; Mooijaart, S. P.; Muller-Nurasyid, M.; Penninx, B.; Revez, J. A.; Rossing, P.; Raikkonen, K.; Sattar, N.; Scharnagl, H.; Sennblad, B.; Silveira, A.; Pourcain, B. S.; Timpson, N. J.; Trollor, J.; Group, C. I. W.; van Dongen, J.; Van Heemst, D.; Visvikis-Siest, S.; Vollenweider, P.; Volker, U.; Waldenberger, M.; Willemsen, G.; Zabaneh, D.; Morris, R. W.; Arnett, D. K.; Baune, B. T.; Boomsma, D. I.; Chang, Y. C.; Deary, I. J.; Deloukas, P.; Eriksson, J. G.; Evans, D. M.; Ferreira, M. A.; Gaunt, T.; Gudnason, V.; Hamsten, A.; Heinrich, J.; Hingorani, A.; Humphries, S. E.; Jukema, J. W.; Koeing, W.; Kumari, M.; Kutalik, Z.; Lawlor, D. A.; Lehtimaki, T.; Marz, W.; Mather, K.; Naitza, S.; Nauck, M.; Ohlsson, C.; Price, J. F.; Raitakari, O.; Rice, K.; Sachdev, P. S.; Slagboom, P. E.; Sorensen, T. I. A.; Spector, T.; Stacey, D.; Stathopoulou, M. G.; Tanaka, T.; Wannamethee, S. G.; Whincup, P.; Rotter, J. I.; Dehghan, A.; Boerwinkle, E.; Psaty, B. M.; Snieder, H.; Alizadeh, B. Z.: Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Hum Mol Genet 5 (30), pp. 393 - 409 (2021)
2020
Journal Article
van den Akker, E. B.; Trompet, S.; Barkey Wolf, J. J. H.; Beekman, M.; Suchiman, H. E. D.; Deelen, J.; Asselbergs, F. W.; Boersma, E.; Cats, D.; Elders, P. M. et al.; Geleijnse, J. M.; Ikram, M. A.; Kloppenburg, M.; Mei, H.; Meulenbelt, I.; Mooijaart, S. P.; Nelissen, R.; Netea, M. G.; Penninx, B.; Slofstra, M.; Stehouwer, C. D. A.; Swertz, M. A.; Teunissen, C. E.; Terwindt, G. M.; t Hart, L. M.; van den Maagdenberg, A.; van der Harst, P.; van der Horst, I. C. C.; van der Kallen, C. J. H.; van Greevenbroek, M. M. J.; van Spil, W. E.; Wijmenga, C.; Zhernakova, A.; Zwinderman, A. H.; Sattar, N.; Jukema, J. W.; van Duijn, C. M.; Boomsma, D. I.; Reinders, M. J. T.; Slagboom, P. E.: Metabolic Age Based on the BBMRI-NL (1)H-NMR Metabolomics Repository as Biomarker of Age-related Disease. Circ Genom Precis Med 13 (5), pp. 541 - 547 (2020)
Journal Article
Pisanti, S.; Deelen, J.; Gallina, A. M.; Caputo, M.; Citro, M.; Abate, M.; Sacchi, N.; Vecchione, C.; Martinelli, R.: Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19. J Transl Med 18 (1), p. 352 (2020)
Journal Article
Gutman, D.; Lidzbarsky, G.; Milman, S.; Gao, T.; Sin-Chan, P.; Gonzaga-Jauregui, C.; Regeneron Genetics, C.; Deelen, J.; Shuldiner, A. R.; Barzilai, N. et al.; Atzmon, G.: Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Aging Cell 19 (10), p. e13216 (2020)
Journal Article
Cohen, A. A.; Kennedy, B. K.; Anglas, U.; Bronikowski, A. M.; Deelen, J.; Dufour, F.; Ferbeyre, G.; Ferrucci, L.; Franceschi, C.; Frasca, D. et al.; Friguet, B.; Gaudreau, P.; Gladyshev, V. N.; Gonos, E. S.; Gorbunova, V.; Gut, P.; Ivanchenko, M.; Legault, V.; Lemaitre, J. F.; Liontis, T.; Liu, G. H.; Liu, M.; Maier, A. B.; Nobrega, O. T.; Rikkert, M.; Pawelec, G.; Rheault, S.; Senior, A. M.; Simm, A.; Soo, S.; Traa, A.; Ukraintseva, S.; Vanhaelen, Q.; Van Raamsdonk, J. M.; Witkowski, J. M.; Yashin, A. I.; Ziman, R.; Fulop, T.: Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev 191, p. 111316 (2020)
Journal Article
Timmers, P.; Wilson, J. F.; Joshi, P. K.; Deelen, J.: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing. Nat Commun 11 (1), p. 3570 (2020)
Journal Article
Deelen, J.: Searching for the genetic key to a long and healthy life. Elife 9 (24), p. e57242 (2020)
Journal Article
Beekman, M.; Schutte, B. A. M.; Akker, E.; Noordam, R.; Dibbets-Schneider, P.; de Geus-Oei, L. F.; Deelen, J.; Rest, O. V.; Heemst, D. V.; Feskens, E. J. M. et al.; Slagboom, P. E.: Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter. Mol Nutr Food Res 64 (10), p. e1900818 (2020)
Journal Article
Klaric, L.; Tsepilov, Y. A.; Stanton, C. M.; Mangino, M.; Sikka, T. T.; Esko, T.; Pakhomov, E.; Salo, P.; Deelen, J.; McGurnaghan, S. J. et al.; Keser, T.; Vuckovic, F.; Ugrina, I.; Kristic, J.; Gudelj, I.; Stambuk, J.; Plomp, R.; Pucic-Bakovic, M.; Pavic, T.; Vilaj, M.; Trbojevic-Akmacic, I.; Drake, C.; Dobrinic, P.; Mlinarec, J.; Jelusic, B.; Richmond, A.; Timofeeva, M.; Grishchenko, A. K.; Dmitrieva, J.; Bermingham, M. L.; Sharapov, S. Z.; Farrington, S. M.; Theodoratou, E.; Uh, H. W.; Beekman, M.; Slagboom, E. P.; Louis, E.; Georges, M.; Wuhrer, M.; Colhoun, H. M.; Dunlop, M. G.; Perola, M.; Fischer, K.; Polasek, O.; Campbell, H.; Rudan, I.; Wilson, J. F.; Zoldos, V.; Vitart, V.; Spector, T.; Aulchenko, Y. S.; Lauc, G.; Hayward, C.: Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Sci Adv 6 (8), p. eaax0301 (2020)
Journal Article
Li, C.; Stoma, S.; Lotta, L. A.; Warner, S.; Albrecht, E.; Allione, A.; Arp, P. P.; Broer, L.; Buxton, J. L.; Da Silva Couto Alves, A. et al.; Deelen, J.; Fedko, I. O.; Gordon, S. D.; Jiang, T.; Karlsson, R.; Kerrison, N.; Loe, T. K.; Mangino, M.; Milaneschi, Y.; Miraglio, B.; Pervjakova, N.; Russo, A.; Surakka, I.; van der Spek, A.; Verhoeven, J. E.; Amin, N.; Beekman, M.; Blakemore, A. I.; Canzian, F.; Hamby, S. E.; Hottenga, J. J.; Jones, P. D.; Jousilahti, P.; Magi, R.; Medland, S. E.; Montgomery, G. W.; Nyholt, D. R.; Perola, M.; Pietilainen, K. H.; Salomaa, V.; Sillanpaa, E.; Suchiman, H. E.; van Heemst, D.; Willemsen, G.; Agudo, A.; Boeing, H.; Boomsma, D. I.; Chirlaque, M. D.; Fagherazzi, G.; Ferrari, P.; Franks, P.; Gieger, C.; Eriksson, J. G.; Gunter, M.; Hagg, S.; Hovatta, I.; Imaz, L.; Kaprio, J.; Kaaks, R.; Key, T.; Krogh, V.; Martin, N. G.; Melander, O.; Metspalu, A.; Moreno, C.; Onland-Moret, N. C.; Nilsson, P.; Ong, K. K.; Overvad, K.; Palli, D.; Panico, S.; Pedersen, N. L.; Penninx, B.; Quiros, J. R.; Jarvelin, M. R.; Rodriguez-Barranco, M.; Scott, R. A.; Severi, G.; Slagboom, P. E.; Spector, T. D.; Tjonneland, A.; Trichopoulou, A.; Tumino, R.; Uitterlinden, A. G.; van der Schouw, Y. T.; van Duijn, C. M.; Weiderpass, E.; Denchi, E. L.; Matullo, G.; Butterworth, A. S.; Danesh, J.; Samani, N. J.; Wareham, N. J.; Nelson, C. P.; Langenberg, C.; Codd, V.: Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet 106 (3), pp. 389 - 404 (2020)
2019
Journal Article
Deelen, J.; Kettunen, J.; Fischer, K.; van der Spek, A.; Trompet, S.; Kastenmuller, G.; Boyd, A.; Zierer, J.; van den Akker, E. B.; Ala-Korpela, M. et al.; Amin, N.; Demirkan, A.; Ghanbari, M.; van Heemst, D.; Ikram, M. A.; van Klinken, J. B.; Mooijaart, S. P.; Peters, A.; Salomaa, V.; Sattar, N.; Spector, T. D.; Tiemeier, H.; Verhoeven, A.; Waldenberger, M.; Wurtz, P.; Davey Smith, G.; Metspalu, A.; Perola, M.; Menni, C.; Geleijnse, J. M.; Drenos, F.; Beekman, M.; Jukema, J. W.; van Duijn, C. M.; Slagboom, P. E.: A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nat Commun 10 (1), p. 3346 (2019)
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