Publications

Talay, A.; Belikov, A. V.; To, P. K. P.; Alfatemi, H. H.; Alon, U.; Deelen, J.; Ewald, C. Y.; Gems, D.; Gorbunova, V.; Gruber, J. et al.; Hägg, S.; Hemming, J.; Horvath, S.; Kaya, A.; Lewis, C. J.; Maier, A. B.; Marinova, M. B.; Pawelec, G.; Peleg, S.; Rattan, S.; Scheibye-Knudsen, M.; Schmauck-Medina, T.; Saroyan, V.; Seluanov, A.; Stolzing, A.; Teeling, E.; Williams, R. W.; White, T.; Unfried, M.; de Magalhães, J. P.: Open problems in ageing science: a roadmap for biogerontology. GeroScience (2025)

Baghdadi, M.; Hinterding, H. M.; Gehrmann, T.; Putter, P.; Neuerburg, M.; Lakenberg, N.; van den Akker, E. B.; Slagboom, P. E.; Deelen, J.; Partridge, L.: Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants. GeroScience (2025)

Gkioni, L.; Nespital, T.; Baghdadi, M.; Monzó, C.; Bali, J.; Nassr , T.; Cremer, A. L.; Beyer, A.; Deelen, J.; Backes, H. et al.; Grönke, S.; Partridge, L.: The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan. Nature Aging (2025)

Kolbe, D.; Dose, J.; Putter, P.; Ziemann, M.; Laudes, M.; Slagboom, P. E.; Franke, A.; Deelen, J.; Nebel, A.: German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway. GeroScience (2025)

Gladyshev, V. N.; Anderson, B.; Barlit, H.; Barre, B.; Beck, S.; Behrouz, B.; Belsky, D. W.; Chaix, A.; Chamoli, M.; Chen, B. H. et al.; Cheng, K.; Chuprin, J.; Churchill, G. A.; Cipriano, A.; Colville, A.; Deelen, J.; Deigin, Y.; Edmonds, K. K.; English, B. W.; Fang, R.; Florea, M.; Gershteyn, I. M.; Gill, D.; Goetz, L. H.; Gorbunova, V.; Griffin, P. T.; Horvath, S.; Borch Jensen, M.; Jin, X.; Jovanovska, S.; Kajderowicz, K. M.; Kasahara, T.; Kerepesi, C.; Kulkarni, S.; Labunskyy, V. M.; Levine, M. E.; Libert, S.; Lu, J. Y.; Lu, Y. R.; Marioni, R. E.; McCoy, B. M.; Mitchell, W.; Moqri, M.; Nasirian, F.; Niimi, P.; Oh, H. S.; Okundaye, B.; Parkhitko, A. A.; Peshkin, L.; Petljak, M.; Poganik, J. R.; Pridham, G.; Promislow, D. E. L.; Prusisz, W.; Quiniou, M.; Raj, K.; Richard, D.; Ricon, J. L.; Rutledge, J.; Scheibye-Knudsen, M.; Schork, N. J.; Seluanov, A.; Shadpour, M.; Shindyapina, A. V.; Shuken, S. R.; Sivakumar, S.; Stoeger, T.; Sugiura, A.; Sutton, N. R.; Suvorov, A.; Tarkhov, A. E.; Teeling, E. C.; Trapp, A.; Tyshkovskiy, A.; Unfried, M.; Ward-Caviness, C. K.; Yim, S. H.; Ying, K.; Yunes, J.; Zhang, B.; Zhavoronkov, A.: Disagreement on foundational principles of biological aging. PNAS Nexus 3 (12), p. pgae499 (2024)

Jia, X.; Fan, J.; Wu, X.; Cao, X.; Ma, L.; Abdelrahman, Z.; Zhao, F.; Zhu, H.; Bizzarri, D.; Akker, E. B. v. d. et al.; Slagboom, P. E.; Deelen, J.; Zhou, D.; Liu, Z.: A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors. Advanced Science (2024)

Sittig, J.; Pickert, L.; Weigert, H.; Deelen, J.; Polidori, C. M.; Nelles, G.: Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up. J Alzheimers Dis. (2024)

Pickert, L.; Dias, I. H. K.; Thimm, A.; Weber, J.; Abdullah, S.; Deelen, J.; Polidori, M. C.: Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study. Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study (2024)

van Holstein, Y.; Mooijaart, S. P.; van Oevelen, M.; van Deudekom, F. J.; Vojinovic, D.; Bizzarri, D.; van den Akker, E. B.; Noordam, R.; Deelen, J.; van Heemst, D. et al.; de Glas, N. A.; Holterhues, C.; Labots, G.; van den Bos, F.; Beekman, M.; Slagboom, P. E.; van Munster, B. C.; Portielje, J. E. A.; Trompet, S.: The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors. GeroScience (2024)

Baghdadi, M.; Nespital, T.; Monzó, C.; Deelen, J.; Grönke, S.; Partridge, L.: Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension. Molecular Metabolism 81, 101902, p. 101902 (2024)

Šetinc, M.; Celinšćak, Ž.; Bočkor, L.; Petranović, M. Z.; Marković, A. S.; Salihović, M. P.; Deelen, J.; Škarić-Jurić, T.: The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age. Mechanisms of Ageing and Development, 111926, p. 111926 (2024)

Smulders, L.; Deelen, J.: Genetics of human longevity: From variants to genes to pathways. Journal of Internal Medicine (2023)

Popescu, I.; Deelen, J.; Illario, M.; Adams, J.: Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan. Journal of Cellular and Molecular Medicine (2023)

Astre, G.; Atlan, T.; Goshtchevsky, U.; Oron-Gottesman, A.; Smirnov, M.; Shapira, K.; Velan, A.; Deelen, J.; Levy, T.; Levanon, E. Y. et al.; Harel, I.: Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate. Developmental Cell (2023)

Treaster, S.; Deelen, J.; Daane, J. M.; Murabito, J.; Karasik, D.; Harris, M. P.: Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. Science Advances 9 (2023)

Cohen, A. A.; Deelen, J.; Jones, O. R.: Editorial: Mechanisms and Pathways Contributing to the Diversity of Aging Across the Tree of Life. Front Cell Dev Biol 10, p. 854700 (2022)

Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2, pp. 19 - 30 (2022)

Baghdadi, M.; Hinterding, H. M.; Partridge, L.; Deelen, J.: From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics 1 (25), pp. 13 - 23 (2022)

Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; Kamatani, Y.; Zhou, W. et al.; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.: Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging. Nature Aging 2 (1), pp. 19 - 30 (2022)

Deelen, J.: Targeting multimorbidity: Using healthspan and lifespan to identify biomarkers of ageing that pinpoint shared disease mechanisms. EBioMedicine 67, p. 103364 (2021)