Constantinos Demetriades, PhD (he/him)

CV

Scientific Career

2019 - present    |    CECAD Associated Principal Investigator
CECAD Research Center, University of Cologne, Germany
2017 - present    |    Max Planck Research Group Leader (Assoc. Prof. level)
Max Planck Institute for Biology of Ageing, Cologne, Germany
2010 - 2016    |    Postdoctoral Researcher
Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany (with Aurelio Teleman)
2006 - 2009    |    Ph.D. Research Associate
Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki, Greece (with George Mosialos)
2003 - 2006    |    Ph.D. Fellow
Institute of Immunology, Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Athens, Greece (with George Mosialos)
2002 - 2003    |    Senior undergraduate thesis
Laboratory of Developmental Biology, Aristotle University of Thessaloniki, Greece (with Margarita Hadzopoulou-Cladaras)

Education

2003 - 2009    |    Doctorate (Ph.D)
2003 - 2006: Institute of Immunology, Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Athens, Greece
2006 - 2009: Department of Genetics, Development and Molecular Biology, Aristotle University of Thessaloniki, Greece
1999 - 2003    |    Degree (Ptychion) in Biology
School of Biology, Aristotle University of Thessaloniki, Greece

Third-party funding

2022 - 2025    |    Research Unit FOR2722 Grant - German Research Foundation (DFG)
2019 - 2022    |    Heineman Project Grant - Minna-James-Heineman Foundation & Minerva Foundation
2018 - 2023    |    ERC Starting Grant - European Research Council (ERC-StG-2017)

Prizes / Awards

2019    |    Walther Flemming Award - German Society for Cell Biology (DGZ)
2014    |    Fellowship from the 14th FEBS Young Scientists` Forum (YSF), August 2014, Paris, France
2011    |    Award from the Alexander S. Onassis Public Benefit Foundation and nomination to attend the 61st Lindau Nobel Laureate Meeting, Lindau, Germany
2004 - 2005    |    Research Scholarship from the Postgraduate Program of the Biomedical Sciences Research Center (BSRC) 'Alexander Fleming', Greece
2001 - 2002    |    Scholarship and Prize from the State Scholarships Foundation (S.S.F.) of Greece for excellence as an undergraduate student of the School of Biology, Aristotle University of Thessaloniki, Greece

Selected Publications

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
Nicastro, R., Brohée, L., Alba, J., Nüchel, J., Figlia, G., Kipschull, S., Gollwitzer, P., Romero-Pozuelo, J., Fernandes, S.A., Lamprakis, A., Vanni, S., Teleman, A.A., De Virgilio, C., Demetriades, C.
(2023) Nat Cell Biol

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
Gollwitzer, P., Grützmacher, N., Wilhelm, S., Kümmel, D., Demetriades, C.
(2022) Nat Cell Biol

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
Nuechel, J., Tauber, M., Nolte, J. L., Morgelin, M., Turk, C., Eckes, B., Demetriades, C., Plomann, M.
(2021) Mol Cell, 81, 16, 3275-3293

Lysosomal recruitment of TSC2 is a universal response to cellular stress
Demetriades C., Plescher M., and Teleman AA.,
(2016) Nature Communications; 7:10662.

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
Demetriades C., Doumpas N., and Teleman AA.,
(2014) Cell.; 156(4):786-99.