Publications
Max Planck Research Group Demetriades
Journal Article (20)
2023
Journal Article
Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor. Aging Cell (2023)
Journal Article
mTORC1 activity negatively regulates human hair follicle growth and pigmentation. EMBO reports (2023)
2022
Journal Article
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids. Nat Cell Biol (2022)
Journal Article
Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor. bioRxiv, p. 2022.12.10.519872 (2022)
Journal Article
2 (9), pp. 796 - 808 (2022)
Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity. Nature Aging
Journal Article
Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor. bioRxiv, p. 2022.11.06.515351 (2022)
2021
Journal Article
5 (11), pp. 173 - 175 (2021)
GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome. Cell Stress
Journal Article
2 (2021)
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging. Frontiers in Aging
Journal Article
81 (16), pp. 3275 - 3293 (2021)
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell
Journal Article
81 (13), pp. 2705 - 2721 (2021)
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell
Journal Article
184 (3), pp. 655 - 674 e27 (2021)
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell 2017
Journal Article
42, pp. 376 - 387.e5 (2017)
CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc. Developmental Cell 2016
Journal Article
7, p. 10662 (2016)
Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun
Journal Article
35 (10), pp. 1058 - 76 (2016)
eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J 2015
Journal Article
5, p. 13828 (2015)
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. Sci Rep 2014
Journal Article
156 (4), pp. 786 - 99 (2014)
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 2011
Journal Article
286 (44), pp. 38768 - 82 (2011)
Genomic analysis reveals a novel nuclear factor-kappaB (NF-kappaB)-binding site in Alu-repetitive elements. J Biol Chem 2009
Journal Article
83 (10), pp. 5269 - 77 (2009)
The LMP1 promoter can be transactivated directly by NF-kappaB. J Virol 2006
Journal Article
273 (9), pp. 1948 - 58 (2006)
Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants. FEBS J 2005
Journal Article
280 (23), pp. 21810 - 9 (2005)
Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha. J Biol Chem