Publications

Nicastro , R.; Brohée, L.; Alba, J.; Nuechel, J.; Figlia, G.; Kipschull, S.; Gollwitzer, P.; Romero-Pozuelo, J.; Fernandes, S. A.; Lamprakis, A. et al.; Vanni, S.; Teleman, A. A.; De Virgilio, C.; Demetriades, C.: Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nature Cell Biology (2023)

Artoni, F.; Grützmacher, N.; Demetriades, C.: Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor. Aging Cell (2023)

Suzuki, T.; Chéret, J.; Scala, F. D.; Akhundlu, A.; Gherardini, J.; Demetrius, D.; O'Sullivan, J. D. B.; Kuka Epstein, G.; Bauman, A. J.; Demetriades, C. et al.; Paus, R.: mTORC1 activity negatively regulates human hair follicle growth and pigmentation. EMBO reports (2023)

Demetriades, C.: Malonyl-CoA links lipid metabolism to nutrient signalling by directly inhibiting mTORC1. Nature Cell Biology 25, pp. 1250 - 1251 (2023)

Priya, A.; Antoine-Bally, S.; Macé, A.-S.; Monteiro, P.; Sabatet, V.; Remy, D.; Dingli, F.; Loew, D.; Demetriades, C.; Gautreau, A. M. et al.; Chavrier, P.: Codependencies of mTORC1 signaling and endolysosomal actin structures. Science Advances 9 (2023)

Gollwitzer, P.; Grützmacher, N.; Wilhelm, S.; Kümmel, D.; Demetriades, C.: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids. Nat Cell Biol (2022)

Artoni, F.; Grützmacher, N.; Demetriades, C.: Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor. bioRxiv, p. 2022.12.10.519872 (2022)

Huang, W.; Kew, C.; Fernandes, S. A.; Löhrke, A.; Han , L.; Demetriades, C.; Antebi, A.: Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity. Nature Aging 2 (9), pp. 796 - 808 (2022)

Nicastro , R.; Brohée, L.; Alba, J.; Nuechel, J.; Figlia, G.; Kipschull , S.; Gollwitzer, P.; Romero-Pozuelo, J.; Fernandes, S. A.; Lamprakis, A. et al.; Vanni, S.; Teleman, A. A.; De Virgilio, C.; Demetriades, C.: Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor. bioRxiv, p. 2022.11.06.515351 (2022)

Demetriades, C.; Nuechel, J.; Plomann, M.: GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome. Cell Stress 5 (11), pp. 173 - 175 (2021)

Fernandes, S. A.; Demetriades, C.: The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging. Frontiers in Aging 2 (2021)

Nuechel, J.; Tauber, M.; Nolte, J. L.; Morgelin, M.; Turk, C.; Eckes, B.; Demetriades, C.; Plomann, M.: An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell 81 (16), pp. 3275 - 3293 (2021)

Fitzian, K.; Bruckner, A.; Brohée, L.; Zech, R.; Antoni, C.; Kiontke, S.; Gasper, R.; Linard Matos, A. L.; Beel, S.; Wilhelm, S. et al.; Gerke, V.; Ungermann, C.; Nellist, M.; Raunser, S.; Demetriades, C.; Oeckinghaus, A.; Kummel, D.: TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol Cell 81 (13), pp. 2705 - 2721 (2021)

Prentzell, M. T.; Rehbein, U.; Cadena Sandoval, M.; De Meulemeester, A. S.; Baumeister, R.; Brohée, L.; Berdel, B.; Bockwoldt, M.; Carroll, B.; Chowdhury, S. R. et al.; von Deimling, A.; Demetriades, C.; Figlia, G.; Genomics England Research, C.; de Araujo, M. E. G.; Heberle, A. M.; Heiland, I.; Holzwarth, B.; Huber, L. A.; Jaworski, J.; Kedra, M.; Kern, K.; Kopach, A.; Korolchuk, V. I.; van 't Land-Kuper, I.; Macias, M.; Nellist, M.; Palm, W.; Pusch, S.; Ramos Pittol, J. M.; Reil, M.; Reintjes, A.; Reuter, F.; Sampson, J. R.; Scheldeman, C.; Siekierska, A.; Stefan, E.; Teleman, A. A.; Thomas, L. E.; Torres-Quesada, O.; Trump, S.; West, H. D.; de Witte, P.; Woltering, S.; Yordanov, T. E.; Zmorzynska, J.; Opitz, C. A.; Thedieck, K.: G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell 184 (3), pp. 655 - 674 e27 (2021)

Romero-Pozuelo, J.; Demetriades, C.; Schroeder, P.; Teleman, A. A.: CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc. Developmental Cell 42, pp. 376 - 387.e5 (2017)

Demetriades, C.; Plescher, M.; Teleman, A. A.: Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun 7, p. 10662 (2016)

Tsokanos, F. F.; Albert, M. A.; Demetriades, C.; Spirohn, K.; Boutros, M.; Teleman, A. A.: eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J 35 (10), pp. 1058 - 76 (2016)

Plescher, M.; Teleman, A. A.; Demetriades, C.: TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. Sci Rep 5, p. 13828 (2015)

Demetriades, C.; Doumpas, N.; Teleman, A. A.: Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 156 (4), pp. 786 - 99 (2014)

Antonaki, A.; Demetriades, C.; Polyzos, A.; Banos, A.; Vatsellas, G.; Lavigne, M. D.; Apostolou, E.; Mantouvalou, E.; Papadopoulou, D.; Mosialos, G. et al.; Thanos, D.: Genomic analysis reveals a novel nuclear factor-kappaB (NF-kappaB)-binding site in Alu-repetitive elements. J Biol Chem 286 (44), pp. 38768 - 82 (2011)