Publications

Gollwitzer, P.; Grützmacher, N.; Wilhelm, S.; Kümmel, D.; Demetriades, C.: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids. Nat Cell Biol (2022)

Artoni, F.; Grützmacher, N.; Demetriades, C.: Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor. bioRxiv, p. 2022.12.10.519872 (2022)

Huang, W.; Kew, C.; Fernandes, S. A.; Löhrke, A.; Han , L.; Demetriades, C.; Antebi, A.: Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity. Nature Aging 2 (9), pp. 796 - 808 (2022)

Nicastro , R.; Brohée, L.; Alba, J.; Nuechel, J.; Figlia, G.; Kipschull , S.; Gollwitzer, P.; Romero-Pozuelo, J.; Fernandes, S. A.; Lamprakis, A. et al.; Vanni, S.; Teleman, A. A.; De Virgilio, C.; Demetriades, C.: Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor. bioRxiv, p. 2022.11.06.515351 (2022)