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Max Planck Research Group Demetriades

Constantinos Demetriades

ERC funding for new drug development

January 18, 2024
Demetriades Grant Institute

Constantinos Demetriades receives Proof of Concept Grant from the European Research Council more

Julian Nüchel in the lab

Focus on the extracellular matrix

December 07, 2023
Career Demetriades Institute

Max Planck postdoc Julian Nüchel becomes Junior Group Leader at the Center for Biochemistry at the University of Cologne more

Molecular structure of the mTOR complex

Metabolism meets signalling to fine-tune cell growth

August 10, 2023
Demetriades Press release

Endogenous metabolite directly inhibits mTORC1 activity more

Pciture of Molecular structure

Same Same, But Different

September 08, 2022
Demetriades

Evolution made nutrient sensing more precise in mammalian cells more

Immune fluorescence microscopy shows that the key UPS regulator, GRASP55, localizes primarily at the Golgi apparatus in non-stressed cells (left panel), whereas it readily relocalizes to secretory vesicles in response to stimuli that cause mTORC1 inhibition (middle panel). mTORC1 regulates GRASP55 directly at the Golgi, where both proteins colocalize in non-stressed cells (right panel, Image taken with the electron microscope).

How do our cells react to starvation or stress?

July 12, 2021
Demetriades Press release

Internal sensor coordinates the cellular stress response to alter the composition of extracellular proteins more

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